MediStreams, a leading provider of healthcare payment and remittance automation solutions, closed a record year in 2025 while advancing the industry’s only true end-to-end remittance processing solution, integrating medical lockbox services, EOB and correspondence conversion, and automated reconciliation across the revenue cycle.

“Our clients and partners are increasingly seeing the value of our true end-to-end reconciliation platform: bringing together EOB conversion and financial reconciliation into a single, unified solution,” said Joe Maher, CFO and President of MediStreams.

“In 2025, we made major investments to further expand our reconciliation suite and embed advanced AI across our market-leading platform to drive greater accuracy, speed, and scalability. These product advancements, combined with deep revenue cycle expertise, allowed us to support more forward-thinking organizations than ever before. We’re proud to be trusted with the most mission-critical components of the revenue cycle, enabling our clients and partners to focus on delivering exceptional patient care,” Maher added.

The Company now supports a significant share of the U.S. healthcare remittance volume, including more than 30 organizations with more than $1 billion in net patient revenue.

2025 by the Numbers: Record Growth and Scale

• 130+ new healthcare organizations added
• 1,100+ provider locations supported
• 350,000+ unique providers served
• 1.7B+ claims processed
• 500M+ remittances converted and reconciled
• $3.6T in claim charges managed
• $186B in payments processed

As MediStreams continues to scale, client satisfaction remains a central priority, as evidenced by the Company’s market-leading NPS score of 73. The Company held its first annual Client Advisory Board (CAB) meeting, bringing together revenue cycle leaders to provide direct feedback on platform enhancements. Several product improvements launched in 2025 were shaped directly by input from this meeting.

Strengthening the Healthcare RCM Ecosystem

Healthcare revenue cycle automation depends on seamless integration across banks, clearinghouses, and practice management systems. In 2025, MediStreams continued expanding its ecosystem to ensure tight, real-time connectivity across the entire workflow.

The MediStreams platform now integrates with:

• 51 healthcare banking partners
• 44 clearinghouse partners
• 63 practice management systems

These integrations position MediStreams at the center of provider RCM workflows, enabling automated ingestion, conversion, reconciliation, and posting across virtually every payment format.

Michael LeBlanc, VP of Revenue Cycle at RadNet, the largest provider of outpatient diagnostic imaging services in the U.S., recently shared in a case study: “MediStreams sits right in the middle of our ecosystem and connects everything: our billing system, our bank, and our people. That’s the key. MediStreams is the glue.”

Product Innovation and Investment

Last year, MediStreams introduced the industry’s first AI-powered correspondence automation solution, addressing one of the most persistent manual burdens in healthcare revenue cycle operations.

Healthcare organizations receive high volumes of payer letters, audit requests, denial documentation, and other correspondence across multiple channels. Traditionally, this process requires extensive manual sorting, indexing, and prioritization.

MediStreams’ AI-driven platform now intelligently extracts, categorizes, and routes critical data from correspondence in real time. By identifying high-impact items and surfacing financial implications immediately, the solution enables RCM teams to prioritize the most time-sensitive and revenue-critical workflows first.

The Company also expanded its API connectivity, enabling direct ingestion and intelligent categorization of payer data feeds. These integrations reduce friction, accelerate workflows, and enhance visibility across the revenue lifecycle.

MediStreams also strengthened its leadership in comprehensive reconciliation automation, spanning financial, posting, and general ledger reconciliation within a single integrated framework. The company plans to publicly launch its enhanced general ledger reconciliation functionality at the upcoming HFMA Revenue Cycle Conference, booth #7.

Operational Readiness, Security, and Scalability

As transaction volumes increased and client complexity expanded, MediStreams continued investing heavily in platform resilience and security. The Company completed its migration to a fully cloud-native architecture, enabling enhanced performance, elastic scalability, and improved system reliability. In addition, MediStreams successfully executed a comprehensive disaster recovery and failover test, validating system continuity under worst-case scenarios and received an unqualified SOC 2 Type 2 audit opinion, reinforcing its commitment to strong internal controls, data protection, and regulatory compliance.

Looking Ahead to 2026

As healthcare reimbursement models continue to evolve, revenue cycle leaders face increasing pressure to reduce manual effort, eliminate unapplied cash, strengthen reconciliation controls, and deliver real-time financial visibility.

MediStreams enters 2026 with strong momentum, an expanding ecosystem, and a differentiated platform built to address these challenges head-on.

For health systems and provider organizations seeking to modernize payment workflows, eliminate manual reconciliation, and strengthen audit readiness, MediStreams remains uniquely positioned to deliver automation across the entire revenue lifecycle. Visit www.medistreams.com to learn more.

About MediStreams

MediStreams provides healthcare payment and remittance automation solutions that streamline complex payment processes. With industry-leading accuracy, real-time visibility, and rapid configurability, the MediStreams solution suite transforms manual processes into automated workflows, empowering organizations to post and reconcile payments faster, more efficiently, and at a lower cost. Follow us on LinkedIn and learn more at www.MediStreams.com.

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“In 2025, we made major investments to further expand our reconciliation suite and embed advanced AI across our market-leading platform to drive greater accuracy, speed, and scalability." -- Joe Maher, MediStreams CFO and President