e10vq
Table of Contents

 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
FORM 10-Q
[ X ] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended March 31, 2010
or
[  ] TRANSITION REPORT UNDER SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT
OF 1934
For the transition period from       to
 
Commission File Number: 001-16633
 
Array BioPharma Inc.
(Exact Name of Registrant as Specified in Its Charter)
     
Delaware
(State or Other Jurisdiction of
Incorporation or Organization)
  84-1460811
(I.R.S. Employer Identification No.)
     
3200 Walnut Street, Boulder, CO   80301
(Address of Principal Executive Offices)   (Zip Code)
(303) 381-6600
(Registrant’s Telephone Number, Including Area Code)
Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.
Yes x No o
Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).
Yes o No o
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer,” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.
Large Accelerated Filer o       Accelerated Filer x
Non-Accelerated Filer o Smaller Reporting Company o
(do not check if smaller reporting company)
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).
Yes o No x
As of April 29, 2010, the registrant had 53,105,714 shares of common stock outstanding.
 

 


 

ARRAY BIOPHARMA INC.
QUARTERLY REPORT ON FORM 10-Q
FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2010
TABLE OF CONTENTS
         
        Page No.
   
 
   
PART I     1
    1
   
 
   
      1
      2
      3
      4
      5
   
 
   
    28
    43
    44
   
 
   
PART II      
    46
    46
    50
    50
    50
    50
    50
   
 
   
SIGNATURES  
 
  51
   
 
   
EXHIBIT INDEX    
 Certification of CEO Pursuant to Section 302
 Certification of CFO Pursuant to Section 302
 Certification of CEO and CFO Pursuant to Section 906

 


Table of Contents

PART I. FINANCIAL INFORMATION
ITEM 1. CONDENSED FINANCIAL STATEMENTS
ARRAY BIOPHARMA INC.
Condensed Balance Sheets
(Amounts in Thousands, Except Share and Per Share Amounts)
(Unaudited)
                 
    March 31,   June 30,
    2010   2009
ASSETS
               
Current assets
               
Cash and cash equivalents
    $ 82,560       $ 33,202  
Marketable securities
    19       7,296  
Prepaid expenses and other current assets
    5,205       4,419  
 
       
Total current assets
    87,784       44,917  
 
       
 
               
Long-term assets
               
Marketable securities
    17,757       16,990  
Property and equipment, net
    22,687       26,498  
Other long-term assets
    3,251       6,650  
 
       
Total long-term assets
    43,695       50,138  
 
       
Total assets
    $ 131,479       $ 95,055  
 
       
 
               
LIABILITIES AND STOCKHOLDERS’ DEFICIT
               
Current liabilities
               
Accounts payable and other accrued expenses
    $ 8,939       $ 8,421  
Accrued outsourcing costs
    5,314       4,759  
Accrued compensation and benefits
    7,478       7,848  
Deferred rent
    3,142       3,034  
Deferred revenue
    41,432       11,233  
Current portion of long-term debt
    -           15,000  
 
       
Total current liabilities
    66,305       50,295  
 
       
 
               
Long-term liabilities
               
Deferred rent
    19,098       21,481  
Deferred revenue
    42,669       28,340  
Long-term debt, net
    111,238       68,170  
Derivative liabilities
    863       -      
Other long-term liability
    797       470  
 
       
Total long-term liabilities
    174,665       118,461  
 
       
Total liabilities
    240,970       168,756  
 
       
 
               
Commitments and contingencies
               
 
               
Stockholders’ deficit
               
Preferred stock, $0.001 par value; 10,000,000 shares authorized, no shares issued or outstanding
    -           -      
Common stock, $0.001 par value; 120,000,000 shares authorized; 51,134,346 and 48,125,776 shares issued and outstanding, as of March 31, 2010 and June 30, 2009, respectively
    51       48  
Additional paid-in capital
    323,213       312,349  
Warrants
    36,296       23,869  
Accumulated other comprehensive income
    5,933       3,234  
Accumulated deficit
    (474,984 )     (413,201 )
 
       
Total stockholders’ deficit
    (109,491 )     (73,701 )
 
       
Total liabilities and stockholders’ deficit
    $ 131,479       $ 95,055  
 
       
The accompanying notes are an integral part of these condensed financial statements.

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ARRAY BIOPHARMA INC.
Condensed Statements of Operations and Comprehensive Loss
(Amounts in Thousands, Except Per Share Data)
(Unaudited)
                                 
    Three Months Ended   Nine Months Ended
    March 31,   March 31,
    2010   2009   2010   2009
Revenue
                               
Collaboration revenue
    $ 5,396       $ 4,399       $ 14,874       $ 13,427  
License and milestone revenue
    12,980       1,639       21,036       6,047  
 
               
Total revenue
    18,376       6,038       35,910       19,474  
 
               
 
                               
Operating expenses
                               
Cost of revenue
    7,946       5,515       19,103       15,698  
Research and development for proprietary drug discovery
    17,692       20,029       55,997       68,248  
General and administrative
    4,264       4,461       12,938       13,435  
 
               
Total operating expenses
    29,902       30,005       88,038       97,381  
 
               
 
                               
Loss from operations
    (11,526 )     (23,967 )     (52,128 )     (77,907
 
                               
Other income (expense)
                               
Impairment of marketable securities
    -           (3,381 )     (217 )     (17,742 )
Gain (loss) on sale of marketable securities
    357       -           1,521       -      
Interest income
    164       412       726       1,823  
Interest expense
    (4,152 )     (2,674 )     (11,685 )     (7,289 )
 
               
Total other income (expense)
    (3,631 )     (5,643 )     (9,655 )     (23,208 )
 
               
 
                               
Net loss
    (15,157 )     (29,610 )     (61,783 )     (101,115 )
 
                               
Change in unrealized gains (losses) on marketable securities
    711       (222 )     2,699       2,171  
 
               
 
                               
Comprehensive loss
    $ (14,446 )     $ (29,832 )     $ (59,084 )     $ (98,944 )
 
               
 
                               
Weighted average shares outstanding - basic and diluted
    50,697       48,068       49,403       47,747  
 
               
 
                               
Net loss per share - basic and diluted
    $ (0.30 )     $ (0.62 )     $ (1.25 )     $ (2.12 )
 
               
The accompanying notes are an integral part of these condensed financial statements.

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ARRAY BIOPHARMA INC.
Condensed Statement of Stockholders’ Deficit
(Amounts in Thousands)
(Unaudited)
                                                                         
                                                    Accumulated        
                                    Additional           Other        
    Preferred Stock   Common Stock   Paid-in           Comprehensive   Accumulated    
    Shares   Amounts   Shares   Amounts   Capital   Warrants   Income   Deficit   Total
Balance as of June 30, 2009
    -           $ -           48,125       $ 48       $ 312,349       $ 23,869       $ 3,234       $ (413,201 )     $ (73,701 )
 
                                                                       
Issuance of common stock under stock option and employee stock purchase plans
    -           -           708       1       1,111       -           -           -           1,112  
Share-based compensation expense
    -           -           -           -           4,177       -           -           -           4,177  
Issuance of common stock for cash, net of offering costs
    -           -           1,301       1       3,165       -           -           -           3,166  
Issuance of common stock warrants
    -           -           -           -           -           12,427       -           -           12,427  
Payment of employee bonus with stock
    -           -           1,000       1       2,411       -           -           -           2,412  
Recognition of unrealized gain out of accumulated other comprehensive income to earnings
    -           -           -           -           -           -           (915 )     -           (915 )
Change in unrealized gain on marketable securities
    -           -           -           -           -           -           3,614       -           3,614  
Net loss
    -           -           -           -           -           -           -           (61,783 )     (61,783 )
 
                                   
 
                                                                       
Balance as of March 31, 2010
    -           $ -           51,134       $ 51       $ 323,213       $ 36,296       $ 5,933       $ (474,984 )     $ (109,491 )
 
                                   
The accompanying notes are an integral part of these condensed financial statements.

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ARRAY BIOPHARMA INC.
Condensed Statements of Cash Flows
(Amounts in Thousands)
(Unaudited)
                 
    Nine Months Ended March 31,
    2010   2009
Cash flows from operating activities
               
Net loss
    $ (61,783 )     $ (101,115 )
Adjustments to reconcile net loss to net cash used in operating activities:
               
Depreciation and amortization expense
    4,837       4,934  
Non-cash interest expense for the Deerfield Credit Facility
    5,047       5,624  
Share-based compensation expense
    4,177       4,283  
Realized gain on marketable securities
    (1,521 )     -      
Impairment of marketable securities
    217       17,742  
Changes in operating assets and liabilities:
               
Prepaid expenses and other current assets
    (76 )     1,048  
Accounts payable and other accrued expenses
    518       1,928  
Accrued outsourcing costs
    555       (6,567 )
Accrued compensation and benefits
    2,042       (697 )
Deferred rent
    (2,275 )     (2,015 )
Deferred revenue
    44,528       702  
 
       
Net cash used in operating activities
    (3,734 )     (74,133 )
 
       
 
               
Cash flows from investing activities
               
Purchases of property and equipment
    (1,026 )     (2,953 )
Purchases of marketable securities
    -           (19,209 )
Proceeds from sales and maturities of marketable securities
    10,840       50,733  
 
       
Net cash provided by investing activities
    9,814       28,571  
 
       
 
               
Cash flows from financing activities
               
Proceeds from exercise of stock options and shares issued under the employee stock purchase plan
    1,112       1,675  
Proceeds from the issuance of common stock for cash
    3,536       -      
Payment of offering costs
    (370 )     -      
Proceeds from the issuance of long-term debt and warrants
    40,000       40,000  
Payment of transaction fee
    (1,000 )     (1,000 )
 
       
Net cash provided by financing activities
    43,278       40,675  
 
       
 
               
Net increase in cash and cash equivalents
    49,358       (4,887 )
Cash and cash equivalents as of beginning of period
    33,202       56,448  
 
       
Cash and cash equivalents as of end of period
    $ 82,560       $ 51,561  
 
       
 
               
Supplemental disclosure of cash flow information
               
Cash paid for interest
    $ 6,106       $ 1,480  
 
       
The accompanying notes are an integral part of these condensed financial statements.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
NOTE 1 - OVERVIEW AND BASIS OF PRESENTATION
Organization
Array BioPharma Inc. (the “Company”) is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer and inflammatory diseases. The Company’s proprietary drug development pipeline includes clinical candidates that are designed to regulate therapeutically important target proteins. In addition, leading pharmaceutical and biotechnology companies partner with the Company to discover and develop drug candidates across a broad range of therapeutic areas.
Basis of Presentation
The Company follows the accounting guidance outlined in the Financial Accounting Standards Board Codification. The accompanying unaudited Condensed Financial Statements have been prepared without audit and do not include all of the disclosures required by the Financial Accounting Standards Board Codification guidelines, which have been omitted pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”) relating to requirements for interim reporting. The year-end condensed balance sheet data was derived from audited financial statements but does not include all disclosures required by accounting principles generally accepted in the United States (“U.S.”). The unaudited Condensed Financial Statements reflect all adjustments (consisting only of normal recurring adjustments) that, in the opinion of management, are necessary to present fairly the financial position of the Company as of March 31, 2010, its results of operations for the three and nine months ended March 31, 2010 and 2009, and its cash flows for the nine months ended March 31, 2010 and 2009. Operating results for the three and nine months ended March 31, 2010 are not necessarily indicative of the results that may be expected for the year ending June 30, 2010.
These unaudited Condensed Financial Statements should be read in conjunction with the Company’s audited Financial Statements and the notes thereto included in the Company’s Annual Report on Form 10-K for the year ended June 30, 2009 filed with the SEC on August 18, 2009.
Certain fiscal 2009 amounts have been reclassified to conform to the current year presentation. Specifically, Accounts Payable and Other Accrued Expenses were aggregated into one line item, Accounts Payable and Other Accrued Expenses, in the accompanying Condensed Balance Sheets.
Use of Estimates
The preparation of financial statements in conformity with accounting principles generally accepted in the U.S. requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting period. Although management bases these estimates on historical data and other assumptions believed to be reasonable under the circumstances, actual results could differ significantly from these estimates.
The Company believes the accounting estimates having the most significant impact on its financial statements relate to (i) estimating the fair value of the Company’s auction rate securities (“ARS”); (ii) estimating accrued outsourcing costs for clinical trials and preclinical testing; (iii) estimating the fair value of the Company’s long-term debt that has associated warrants and embedded derivatives, and the separate valuation of those warrants and embedded derivatives; and (iv) estimating the lives over which up-front and milestone payments from collaboration agreements are recognized.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Liquidity
The Company has incurred operating losses and has an accumulated deficit primarily as a result of ongoing research and development spending. As of March 31, 2010, the Company had an accumulated deficit of $475.0 million. The Company had net losses of $15.2 million and $29.6 million for the three months ended March 31, 2010 and 2009, respectively, and $61.8 million and $101.1 million for the nine months ended March 31, 2010 and 2009, respectively. The Company had net losses of $127.8 million, $96.3 million and $55.4 million for the fiscal years ended June 30, 2009, 2008 and 2007, respectively.
The Company has historically funded its operations through payments under its collaborations and out-licensing transactions, the issuance of equity securities and through debt provided by its credit facilities. Until the Company can generate sufficient levels of cash from its operations, which the Company does not expect to achieve in the foreseeable future, the Company will continue to utilize its existing cash, cash equivalents and marketable securities that were generated primarily from these sources.
The Company believes that its cash, cash equivalents and marketable securities, including the $45 million upfront and milestone payment from Novartis International Pharmaceutical Ltd. discussed below and excluding the value of the ARS it holds, will enable it to continue to fund its operations for more than the next 12 months. The Company’s current operating plan contemplates the receipt of significant additional upfront payments from new collaboration or licensing deals and milestone payments from existing collaborations in the next 12 months. The Company is currently in active licensing discussions with a number of potential partners on select programs and recently entered into two new licensing transactions that include upfront and milestone payments as well as royalties. In December 2009, the Company received a $60 million up front payment from Amgen Inc. under a Collaboration and License Agreement with Amgen for the Company’s small-molecule glucokinase activator, AMG 151 / ARRY-403. In April 2010, the Company signed a License Agreement with Novartis International Pharmaceutical Ltd. under which the Company will receive $45 million in an upfront and milestone payment in the fourth quarter of fiscal 2010, as discussed further in Note 10 “Subsequent Event.” There can be no guarantee, however, that the Company will be successful in entering into new collaboration or licensing transactions that include upfront and milestone payments or that the milestones will be achieved under existing collaborations resulting in the payment of milestone payments when anticipated.
If the Company is unable to obtain additional funding from these or other sources to the extent or when needed, it may be necessary to significantly reduce its current rate of spending through further reductions in staff and delaying, scaling back or stopping certain research and development programs. Insufficient funds may also require the Company to relinquish greater rights to product candidates at an earlier stage of development or on less favorable terms to it or its stockholders than the Company would otherwise choose in order to obtain up-front license fees needed to fund its operations.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Fair Value Measurements
The Company’s financial instruments are recognized and measured at fair value in the Company’s financial statements and mainly consist of cash and cash equivalents, marketable securities, long-term investments, trade receivables and payables, long-term debt, embedded derivatives associated with the long-term debt, and warrants. The Company uses different valuation techniques to measure the fair value of assets and liabilities, as discussed in more detail below. Fair value is defined as the price that would be received to sell the financial instruments in an orderly transaction between market participants at the measurement date. The Company uses a framework for measuring fair value based on a hierarchy that distinguishes sources of available information used in fair value measurements and categorizes them into three levels:
         
  Level I:   Quoted prices in active markets for identical assets and liabilities.
  Level II:   Observable inputs other than quoted prices in active markets for identical assets and liabilities.
  Level III:   Unobservable inputs.
The Company discloses assets and liabilities measured at fair value based on their level in the hierarchy. Considerable judgment is required in interpreting market data to develop estimates of fair value for assets or liabilities for which there are no quoted prices in active markets, which include the Company’s ARS, warrants issued by the Company and the embedded derivatives associated with the Company’s long-term debt. The use of different assumptions and/or estimation methodologies may have a material effect on their estimated fair value. Accordingly, the fair value estimates disclosed by the Company may not be indicative of the amount that the Company or holders of the instruments could realize in a current market exchange.
The Company periodically reviews the realizability of each investment when impairment indicators exist with respect to the investment. If an other-than-temporary impairment of the value of an investment is deemed to exist, the carrying value of the investment is written down to its estimated fair value.
Cash and Cash Equivalents
Cash equivalents consist of short-term, highly liquid financial instruments that are readily convertible to cash and have maturities of 90 days or less from the date of purchase and may consist of money market funds, taxable commercial paper, U.S. government agency obligations and corporate notes and bonds with high credit quality.
Marketable Securities
The Company has designated its marketable securities as of March 31, 2010 and June 30, 2009 as available-for-sale securities and accounts for them at their respective fair values. Marketable securities are classified as short-term or long-term based on the nature of these securities and the availability of these securities to meet current operating requirements. Marketable securities that are readily available for use in current operations are classified as short-term available-for-sale securities and are reported as a component of current assets in the accompanying Condensed Balance Sheets. Marketable securities that are not considered available for use in current operations are classified as long-term available-for-sale securities and are reported as a component of long-term assets in the accompanying Condensed Balance Sheets.
Securities that are classified as available-for-sale are carried at fair value, including accrued interest, with temporary unrealized gains and losses reported as a component of Stockholders’ Deficit until their disposition. The Company reviews all available-for-sale securities each period to determine if they will remain available-for-sale based on the Company’s then current intent and ability to sell the security if it is

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
required to do so. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization is included in Interest Income in the accompanying Condensed Statements of Operations and Comprehensive Loss. Realized gains and losses are reported in Realized Gains (Losses) on Sales of Marketable Securities in the accompanying Condensed Statements of Operations and Comprehensive Loss as incurred. Declines in value judged to be other-than-temporary are reported in Impairment of Marketable Securities in the accompanying Condensed Statements of Operations and Comprehensive Loss as recognized. The cost of securities sold is based on the specific identification method.
Under the fair value hierarchy, the Company’s ARS are measured using Level III, or unobservable inputs, as there is no active market for the securities. The most significant unobservable inputs used in this method are estimates of the amount of time until a liquidity event will occur and the discount rate, which incorporates estimates of credit risk and a liquidity premium (discount). Due to the inherent complexity in valuing these securities, the Company engaged a third-party valuation firm to perform an independent valuation of the ARS beginning with the first quarter of fiscal 2009 and continuing through the current fiscal quarter. While the Company believes that the estimates used in the fair value analysis are reasonable, a change in any of the assumptions underlying these estimates would result in different fair value estimates for the ARS and could result in additional adjustments to the ARS, either increasing or further decreasing their value, possibly by material amounts.
Property and Equipment
Property and equipment are stated at historical cost less accumulated depreciation and amortization. Additions and improvements are capitalized. Certain costs to internally develop software are also capitalized. Maintenance and repairs are expensed as incurred.
Depreciation and amortization are computed on the straight-line method based on the following estimated useful lives:
     
Furniture and fixtures
  7 years
Equipment
  5 years
Computer hardware and software
  3 years
The Company depreciates leasehold improvements associated with operating leases on a straight-line basis over the shorter of the expected useful life of the improvements or the reasonably assured term of the leases.
The carrying value for property and equipment is reviewed for impairment when events or changes in circumstances indicate the book value of the assets may not be recoverable. An impairment loss would be recognized when estimated undiscounted future cash flows from the use of the asset and its eventual disposition is less than its carrying amount.
Equity Investment
The Company has and may continue to enter into collaboration and licensing agreements in which it receives an equity interest in consideration for all or a portion of up-front, license or other fees under the terms of the agreement. The Company reports the value of equity securities received from non-publicly traded companies in which it does not exercise a significant controlling interest at cost as Other Long-term Assets in the accompanying Condensed Balance Sheets. The Company monitors its investment for impairment at least annually and makes appropriate reductions in the carrying value if it is determined that an impairment has occurred, based primarily on the financial condition and near term prospects of the issuer.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Accrued Outsourcing Costs
Substantial portions of the Company’s preclinical studies and clinical trials are performed by third-party laboratories, medical centers, contract research organizations, and other vendors (collectively “CROs”). These CROs generally bill monthly or quarterly for services performed or bill based upon milestone achievement. For preclinical studies, the Company accrues expenses based upon estimated percentage of work completed and the contract milestones remaining. For clinical studies, expenses are accrued based upon the number of patients enrolled and the duration of the study. The Company monitors patient enrollment, the progress of clinical studies and related activities to the extent possible through internal reviews of data reported to it by the CROs, correspondence with the CROs and clinical site visits. The Company’s estimates depend on the timeliness and accuracy of the data provided by its CROs regarding the status of each program and total program spending. The Company periodically evaluates the estimates to determine if adjustments are necessary or appropriate based on information it receives.
Deferred Revenue
The Company records amounts received under its collaboration agreements, but not earned, as Deferred Revenue, which are then classified as current or long-term in the accompanying Condensed Balance Sheets based on period over which they are expected to be recognized as revenue.
Long-term Debt and Embedded Derivatives
The terms of the Company’s long-term debt are discussed in detail in Note 5 “Long-term Debt.” The accounting for these arrangements is complex and is based upon significant estimates by management. The Company reviews all debt agreements to determine the appropriate accounting treatment when the agreement is entered into, and reviews all amendments to determine if the changes require accounting for the amendment as a modification, or as an extinguishment and new debt. The Company also reviews each long-term debt arrangement to determine if any feature of the debt requires bifurcation and/or separate valuation. These features include hybrid instruments, which are comprised of at least two components ((1) a debt host instrument and (2) one or more conversion features), warrants and other embedded derivatives, such as puts and other rights of the debt holder.
The Company currently has two embedded derivatives related to its long-term debt with Deerfield. The first is a variable interest rate structure that constitutes a liquidity-linked variable spread feature. The second derivative is a significant transaction contingent put option relating to the ability of Deerfield to accelerate the repayment of the debt in the event of certain changes in control of the Company. Collectively, they are referred to as the “Embedded Derivatives.” Under the fair value hierarchy, the Company’s Embedded Derivatives are measured using Level III, or unobservable inputs as there is no active market for them. The fair value of the variable interest rate structure is based on the Company’s estimate of the probable effective interest rate over the term of the credit facilities. The fair value of the put option is based on the Company’s estimate of the probability that a change in control that triggers Deerfield’s right to accelerate the debt will occur. With those inputs, the fair value of each Embedded Derivative is calculated as the difference between the fair value of the Deerfield credit facilities if the Embedded Derivatives are included, and the fair value of the Deerfield credit facilities if the Embedded Derivatives are excluded. Due to the inherent complexity in valuing the Deerfield credit facilities and the Embedded Derivatives, the Company engaged a third-party valuation firm to perform the valuation as of July 31, 2009 and continuing through the current quarter. The estimated fair value of the Embedded Derivatives was determined based on management’s judgment and assumptions. The use of different assumptions could result in significantly different estimated fair values.
The fair value of the Embedded Derivatives was initially recorded as Derivative Liabilities and as Debt Discount in the Company’s accompanying Condensed Balance Sheets. Any change in the value of the Embedded Derivatives is adjusted quarterly as appropriate and recorded to Derivative Liabilities in the Condensed Balance Sheets and Interest Expense in the accompanying Condensed Statements of

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Operations and Comprehensive Loss. The Debt Discount is being amortized from the draw date of July 31, 2009 to the end of the term of the Deerfield credit facilities using the effective interest method and recorded as Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss.
Warrants issued by the Company in connection with its long-term debt arrangements are reviewed to determine if they should be classified as liabilities or as equity. All outstanding warrants issued by the Company have been classified as equity. The Company values the warrants at issuance based on a Black-Scholes option pricing model and then allocates a portion of the proceeds under the debt to the warrants based upon their relative fair values.
Any transaction fees relating to the Company’s long-term debt arrangements that qualify for capitalization are recorded as Other Long-Term Assets in the Condensed Balance Sheets and amortized to Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss using the effective interest method over the term of the underlying debt agreement.
Income Taxes
The Company accounts for income taxes using the asset and liability method. The Company recognizes the amount of income taxes payable or refundable for the year as well as deferred tax assets and liabilities. Deferred tax assets and liabilities are determined based on the difference between the financial statement carrying value and the tax basis of assets and liabilities, and, using enacted tax rates in effect for the year, reflect the expected effect these differences would have on taxable income. Valuation allowances are recorded to reduce the amount of deferred tax assets when, based upon available objective evidence, the expected reversal of temporary differences, and projections of future taxable income, management cannot conclude it is more likely than not that some or all of the deferred tax assets will be realized.
Operating Leases
The Company has negotiated certain landlord/tenant incentives, and rent holidays and escalations in the base price of rent payments under its operating leases. For purposes of determining the period over which these amounts are recognized or amortized, the initial term of an operating lease includes the “build-out” period of leases, where no rent payments are typically due under the terms of the lease, and includes additional terms pursuant to any options to extend the initial term if it is more likely than not that the Company will exercise such options. The Company recognizes rent holidays and rent escalations on a straight-line basis over the initial lease term. The landlord/tenant incentives are recorded as an increase to Deferred Rent in the accompanying Condensed Balance Sheets and amortized on a straight-line basis over the initial lease term. The Company has also entered into two sale-lease back transactions for its facilities in Boulder and Longmont, Colorado, where the consideration received from the landlord is recorded as increases to Deferred Rent in the accompanying Condensed Balance Sheets and amortized on a straight-line basis over the initial lease term. Deferred Rent balances are classified as short-term or long-term in the accompanying Condensed Balance Sheets based upon when reversal of the liability is expected to occur.
Share-Based Compensation
The Company uses the fair value method of accounting for share-based compensation arrangements which requires that compensation expense be recognized based on the grant date fair value of the arrangement. Share-based compensation arrangements include stock options granted under the Company’s Amended and Restated Stock Option and Incentive Plan (the “Option Plan”) and purchases of common stock by its employees at a discount to the market price under the Company’s Employee Stock Purchase Plan (the “ESPP”).

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
The estimated fair value of stock options is based on the Black-Scholes option pricing model and is expensed on a straight-line basis over the vesting term. Compensation expense for stock options is reduced for estimated forfeitures, which are estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. Compensation expense for purchases under the ESPP is recognized based on a Black-Scholes option pricing model that incorporates the estimated fair value of the common stock during each offering period and the percentage of the purchase discount.
Revenue Recognition
Most of the Company’s revenue is from the Company’s collaborators for research funding, up-front or license fees and milestone payments derived from discovering and developing drug candidates. The Company’s agreements with collaboration partners include fees based on contracted annual rates for full-time-equivalent employees working on a program, and may also include non-refundable license and up-front fees, non-refundable milestone payments that are triggered upon achievement of specific research or development goals, and future royalties on sales of products that result from the collaboration. A small portion of the Company’s revenue comes from the sale of compounds on a per-compound basis. The Company reports revenue for discovery, the sale of chemical compounds and the co-development of proprietary drug candidates that the Company out-licenses, as Collaboration Revenue. License and Milestone Revenue is combined and consists of the current period’s recognized up-front fees and ongoing milestone payments from collaborators.
The Company recognizes revenue in accordance with Staff Accounting Bulletin No. 104, Revenue Recognition (“SAB 104”), which establishes four criteria, each of which must be met, in order to recognize revenue related to the performance of services or the shipment of products. Revenue is recognized when (a) persuasive evidence of an arrangement exists, (b) products are delivered or services are rendered, (c) the sales price is fixed or determinable, and (d) collectability is reasonably assured.
Collaboration agreements that include a combination of discovery research funding, up-front or license fees, milestone payments and/or royalties are evaluated to determine whether each deliverable under the agreement has value to the customer on a stand-alone basis and whether reliable evidence of fair value for the deliverable exists. Deliverables in an arrangement that do not meet the separation criteria are treated as a single unit of accounting, generally applying applicable revenue recognition guidance for the final deliverable to the combined unit of accounting in accordance with SAB 104.
The Company recognizes revenue from non-refundable up-front payments and license fees on a straight-line basis over the term of performance under the agreement, which is generally the estimated research term. These advance payments are deferred and recorded as Deferred Revenue upon receipt, pending recognition, and are classified as a short-term or long-term liability in the accompanying Condensed Balance Sheets. When the performance period is not specifically identifiable from the agreement, the Company estimates the performance period based upon provisions contained within the agreement, such as the duration of the research term, the specific number of full-time-equivalent scientists working a defined number of hours per year at a stated price under the agreement, the existence, or likelihood of achievement, of development commitments, and other significant commitments of the Company.
The Company also has agreements that provide for milestone payments. In certain cases, a portion of each milestone payment is recognized as revenue when the specific milestone is achieved based on the applicable percentage of the estimated research or development term that has elapsed to the total estimated research and/or development term. In other cases, when the milestone payment finances future development obligations of the Company, the revenue is recognized on a straight-line basis over the estimated remaining development period. Certain milestone payments are related to activities for which there are no future obligations, and as a result, are recognized when earned in their entirety.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
The Company periodically reviews the expected performance periods under each of its agreements that provide for non-refundable up-front payments and license fees and milestone payments, and adjusts the amortization periods when appropriate to reflect changes in assumptions relating to the duration of expected performance periods. Revenue recognition related to non-refundable license fees and up-front payments and to milestone payments could be accelerated in the event of early termination of programs or alternatively, decelerated, if programs are extended.
Cost of Revenue and Research and Development Expenses for Proprietary Drug Discovery
The Company incurs costs in connection with performing research and development activities which consist mainly of compensation, associated fringe benefits, share-based compensation, preclinical and clinical outsourcing costs and other collaboration-related costs, including supplies, small tools, facilities, depreciation, recruiting and relocation costs and other direct and indirect chemical handling and laboratory support costs. The Company allocates these costs between Cost of Revenue and Research and Development Expenses for Proprietary Drug Discovery based upon the respective time spent by its scientists on development conducted for its collaborators and for its internal proprietary programs, respectively. Cost of Revenue represents the costs associated with research and development, including preclinical and clinical trials, conducted by the Company for its collaborators. Research and Development Expenses for Proprietary Drug Discovery consist of direct and indirect costs related to specific proprietary programs. The Company does not bear any risk of failure for performing these activities and the payments are not contingent on the success or failure of the research program. Accordingly, the Company expenses these costs when incurred.
Where the Company’s collaboration agreements provide for it to conduct research or development, and for which the Company’s partner has an option to obtain the right to conduct further development and to commercialize a product, the Company attributes a portion of its research and development costs to Cost of Revenue based on the percentage of total programs under the agreement that the Company concludes is likely to be selected by the partner. These costs may not be incurred equally across all programs. In addition, the Company continually evaluates the progress of development activities under these agreements and if events or circumstances change in future periods that the Company reasonably believes would make it unlikely that a collaborator would exercise an option with respect to the same percentage of programs, the Company will adjust the allocation accordingly.
For example, the Company granted Celgene Corporation an option to select up to two of four programs developed under its collaboration agreement with Celgene and concluded that Celgene was likely to exercise its option with respect to two of the four programs. Accordingly, the Company reported costs associated with the Celgene collaboration as follows: 50% to Cost of Revenue, with the remaining 50% to Research and Development Expenses for Proprietary Drug Discovery. Celgene waived its rights with respect to one of the programs during the second quarter of fiscal 2010, at which time management determined that Celgene is likely to exercise its option to license one of the remaining three programs. Accordingly, beginning October 1, 2009, the Company began reporting costs associated with the Celgene collaboration as follows: 33.3% to Cost of Revenue, with the remaining 66.7% to Research and Development Expenses for Proprietary Drug Discovery. See Note 4 “Deferred Revenue,” for further information about the Company’s collaboration with Celgene.
Net Loss per Share
Basic net loss per share is computed by dividing net loss for the period by the weighted averaged number of common shares outstanding during the period. Diluted net loss per share reflects the additional dilution from potential issuances of common stock, such as stock issuable pursuant to the exercise of stock options and warrants issued related to the Company’s long-term debt. The treasury stock method is used to calculate the potential dilutive effect of these common stock equivalents. Potentially dilutive shares are excluded from the computation of diluted net loss per share when their effect is anti-dilutive. As a result of the Company’s net losses through the date of these Condensed Financial Statements, all potentially

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
dilutive securities were anti-dilutive and therefore have been excluded from the computation of diluted net loss per share.
Comprehensive Income (Loss)
The Company’s comprehensive income (loss) consists of the Company’s net loss and unrealized gains and losses on investments in available-for-sale marketable securities. The Company had no other sources of comprehensive income (loss) for the fiscal periods presented.
Recent Accounting Pronouncements
Collaborative Arrangements - In the first quarter of fiscal 2010, new guidance relating to the accounting practices and disclosures for collaborative arrangements became effective. A collaborative arrangement is a contractual arrangement that involves a joint operating activity. These arrangements involve two (or more) parties who are both (a) active participants in the activity and (b) exposed to significant risks and rewards dependent on the commercial success of the activity. If the Company’s collaboration agreements are determined to be collaborative arrangements, additional disclosures may be required by this guidance beginning with this Quarterly Report on Form 10-Q. The Company determined that while certain agreements are collaborative arrangements, none of the current activities being performed under those arrangements would require a change to the accounting practices or disclosures made by the Company in its Quarterly Reports on Form 10-Q and Annual Reports on Form 10-K.
Convertible Debt - In the first quarter of fiscal 2010, guidance relating to the accounting for “convertible debt” became effective. The Company determined that none of its credit facilities are considered “convertible debt” as defined under this accounting guidance and therefore this pronouncement had no impact on its financial statements and disclosures.
Fair Value Measurements - In August 2009 and January 2010, new literature was issued giving companies additional guidance relating to the fair value measurements and disclosures of liabilities. The guidance issued in August 2009 was effective for the Company for the first quarter of fiscal 2010 and was adopted at that time. The guidance issued in January 2010 was effective for the Company for the third quarter of fiscal 2010 and was adopted at that time. The effect of these new literatures is reflected in the accompanying Condensed Financial Statements.
Revenue Recognition for Multiple Deliverable Arrangements - In October 2009, new guidance was issued related to multiple-deliverable revenue arrangements that are effective for the Company prospectively for revenue arrangements entered into or materially modified subsequent to July 1, 2010. The objective of this change is to address the accounting for multiple-deliverable arrangements to enable companies to account more easily for products or services (deliverables) separately rather than as a combined unit. The Company is currently evaluating the impact of this guidance on its financial statements.
Subsequent Events - In February 2010, new guidance was issued related to the recognition and disclosure of subsequent events. The guidance was effective when issued, and all material events occurring subsequent to March 31, 2010 are disclosed in the accompanying Condensed Financial Statements.
Milestone Revenue Recognition - In March 2010, new guidance was issued related to accounting for milestone revenue recognition. The guidance is effective for the Company for the first quarter of fiscal 2011 though early adoption is permitted. The Company adopted the guidance in the current quarter which didn’t have a material impact on the Company’s accompanying Condensed Financial Statements.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
NOTE 2 – SEGMENTS, GEOGRAPHIC INFORMATION AND SIGNIFICANT COLLABORATORS
Segments
All operations of the Company are considered to be in one operating segment and, accordingly, no segment disclosures have been presented. The physical location of all of the Company’s equipment, leasehold improvements and other fixed assets is within the U.S.
Geographic Information
All of the Company’s collaboration agreements are denominated in U.S. dollars. The following table details revenue from collaborators by geographic area based on the country in which collaborators are located or the ship-to destination for the compounds (dollars in thousands):
                                   
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
                                 
North America
    $ 18,310       $ 6,005       $ 35,706       $ 19,111  
Europe
    52       25       161       333  
Asia Pacific
    14       8       43       30  
 
               
 
    $ 18,376       $ 6,038       $ 35,910       $ 19,474  
 
               
Significant Collaborators
The following collaborators contributed greater than 10% of total revenue during the periods set forth below:
                                   
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
                                 
Amgen Inc.
    34.7     0.0     20.3     0.0
Celgene Corporation
    22.5 %     23.7 %     27.5 %     22.0 %
Genentech, Inc.
    42.1 %     70.6 %     48.0 %     66.4 %
 
               
 
    99.3 %     94.3 %     95.8 %     88.4 %
 
               
The loss of one or more significant collaborators could have a material adverse effect on the Company’s business, operating results or financial condition. The Company does not require collateral to secure the payment obligations of its collaborators. Although the Company is impacted by economic conditions in the biotechnology and pharmaceutical sectors, most collaborators pay in advance and management does not believe significant credit risk exists in its recorded accounts receivable as of March 31, 2010.
NOTE 3 – MARKETABLE SECURITIES
The Company’s investments in marketable securities include domestic public corporate debt securities, commercial paper issued by domestic public companies, obligations of U.S. federal government agencies and ARS. All of these investments are held in the name of the Company at a limited number of financial institutions. The Company’s investments in marketable securities were all classified as available-for-sale as of March 31, 2010 and June 30, 2009.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Marketable securities consisted of the following as of March 31, 2010 (dollars in thousands):
                                 
            Gross     Gross        
    Amortized     Unrealized     Unrealized     Fair  
    Cost     Gains     Losses     Value  
     
                                 
Short-term available-for-sale securities:
                               
Mutual fund securities
    $ 19       $     -       $     -       $ 19  
 
               
Sub-total
    19           -           -       19  
 
               
 
                               
Long-term available-for-sale securities:
                               
Auction rate securities
    11,028       5,933           -       16,961  
Mutual fund securities
    796           -           -       796  
 
               
Sub-total
    11,824       5,933           -       17,757  
 
               
 
                               
Total
    $ 11,843       $ 5,933       $     -       $ 17,776  
 
               
Marketable securities consisted of the following as of June 30, 2009 (dollars in thousands):
                                 
            Gross     Gross        
    Amortized     Unrealized     Unrealized     Fair  
    Cost     Gains     Losses     Value  
     
                                 
Short-term available-for-sale securities:
                               
U.S. Government agency securities
    7,059           -           -       7,059  
Mutual fund securities
    237           -           -       237  
 
               
Sub-total
    7,296           -           -       7,296  
 
               
 
                               
Long-term available-for-sale securities:
                               
Auction rate securities
    13,284       3,234           -       16,518  
Mutual fund securities
    472           -           -       472  
 
               
Sub-total
    13,756       3,234           -       16,990  
 
               
 
                               
Total
    $ 21,052       $ 3,234       $     -       $ 24,286  
 
               
The fair value measurement categories of these marketable securities as of March 31, 2010 and June 30, 2009 were as follows (dollars in thousands):
                 
    March 31,     June 30,  
    2010   2009
                 
Quoted prices in active markets for identical assets (Level 1)
    $ 815       $ 7,768  
Significant unobservable inputs (Level 3)
    16,961       16,518  
 
       
 
    $ 17,776       $ 24,286  
 
       

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
The amortized cost and estimated fair value of available-for-sale securities by contractual maturity as of March 31, 2010 is as follows (dollars in thousands):
                 
    Amortized     Fair  
    Cost   Value
 
Due in one year or less
    $ 19       $ 19  
Due in one year to three years
    796       796  
Due after 10 years or more
    11,028       16,961  
 
       
 
    $ 11,843       $ 17,776  
 
       
Auction Rate Securities
The Company’s ARS are currently not liquid. Auctions in the related markets for the ARS were unsuccessful during fiscal 2009 and were suspended during the first and second quarters of fiscal 2009. The lack of successful auctions resulted in the interest rate on these investments increasing to LIBOR plus additional basis points as stipulated in the auction rate agreements, ranging from 200 to 350 additional basis points, which has continued through the current fiscal quarter. While the Company now earns a higher contractual interest rate on these investments, the investments may not be liquid at a time when the Company needs to access these funds. In the event the Company needs to access these funds and liquidate the ARS prior to the time auctions of these investments are successful or the date on which the original issuers retire these securities, the Company may be required to sell them in a distressed sale in a secondary market, most likely for a lower value than their current estimated fair value.
As of March 31, 2010, the Company held five securities with a par value of $26.3 million and an estimated fair value of $17.0 million. As of June 30, 2009, the Company held seven securities with a par value of $32.9 million and an estimated fair value of $16.5 million. The Company sold one of the ARS in the second quarter of fiscal 2010 with a par value of $4.0 million for $2.8 million and realized a gain of $1.2 million, with $394 thousand recognized from Accumulated Other Comprehensive Income. The Company sold one of the ARS in the third quarter of fiscal 2010 with a par value of $2.6 million for $715 thousand and realized a gain of $357 thousand, with $524 thousand recognized from Accumulated Other Comprehensive Income.
Under the fair value hierarchy, the Company’s ARS are measured using Level III, or unobservable inputs, as there is no active market for the securities. The most significant unobservable inputs used in this method are estimates of the amount of time until a liquidity event will occur and the discount rate, which incorporates estimates of credit risk and a liquidity premium (discount). Due to the inherent complexity in valuing these securities, the Company engaged a third-party valuation firm to perform an independent valuation of the ARS beginning with the first quarter of fiscal 2009 and continuing through the current fiscal quarter.
While the Company believes that the estimates used in the fair value analysis are reasonable, a change in any of the assumptions underlying these estimates would result in different fair value estimates for the ARS and could result in additional changes to the ARS values, either increasing or decreasing their value.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Based on its fair value analysis and fair value estimates as of each quarter end, the Company recorded adjustments to the fair value of its ARS that are summarized below (dollars in thousands):
                                 
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
                                 
Unrealized gains
    $ 1,210       $     -       $ 3,614       $     -  
 
               
 
                               
Realized gains
    $ 357       $     -       $ 1,521       $     -  
 
               
 
                               
Losses attributable to the change in unrealized losses
    $     -       $     -       $     -       $ (1,939 )
Other current period losses
        -       (3,381 )     (217 )     (15,803 )
 
               
Total impairment of marketable securities
    $     -       $ (3,381 )     $ (217 )     $ (17,742 )
 
               
The Company has recorded cumulative net fair value declines to its five ARS of $11.9 million as of March 31, 2010.
A rollforward of adjustments to the fair value of the ARS for the nine months ended March 31, 2010 and 2009 follows (dollars in thousands):
                 
    Nine Months Ended March 31,  
    2010   2009
         
Balance as of prior year end
    $ 16,518       $ 29,089  
Add: Current period gains included in equity
    3,614       239  
Add: Current period gains included in earnings
    1,521           -  
Less: Sale of ARS
    (3,560 )         -  
Less: Recognition of unrealized gain from Accumulated Other Comprehensive Income
    (915 )         -  
Less: Current period losses included in earnings
    (217 )     (15,803
 
       
Balance as of current quarter end
    $ 16,961       $ 13,525  
 
       

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
NOTE 4 – DEFERRED REVENUE
Deferred revenue consisted of the following (dollars in thousands):
                 
    March 31,     June 30,  
    2010   2009
 
Amgen, Inc.
    $ 55,521       $     -  
Celgene Corporation
    24,591       34,429  
Genentech, Inc.
    3,989       5,060  
Other
        -       84  
 
       
Total deferred revenue
    84,101       39,573  
Less: Current portion
    (41,432 )     (11,233
 
       
Deferred revenue, long term
    $ 42,669       $ 28,340  
 
       
Amgen Inc.
In December 2009, the Company granted Amgen the exclusive worldwide right to develop and commercialize the Company’s small-molecule glucokinase activator, AMG 151 / ARRY-403. Under the Collaboration and License Agreement, the Company is responsible for completing Phase 1 clinical trials on AMG 151 / ARRY-403. The Company will also conduct further research funded by Amgen to create second generation glucokinase activators. Amgen is responsible for further development and commercialization of AMG 151 / ARRY-403 and any resulting second generation compounds. The agreement also provides the Company with an option to co-promote any approved drugs with Amgen in the U.S. with certain limitations.
In partial consideration for the rights granted to Amgen under the agreement, Amgen paid the Company an up-front fee of $60 million. Amgen will also pay the Company for research on second generation compounds based on the number of full-time-equivalent scientists working on the discovery program. The Company is also entitled to receive up to approximately $666 million in aggregate milestone payments if all clinical and commercialization milestones specified in the Agreement for AMG 151 / ARRY-403 and at least one backup compound are achieved. The Company will also receive royalties on sales of any approved drugs developed under the agreement.
The Company estimates that its obligations under the agreement will continue until December 31, 2012 and, therefore, is recognizing the up-front fee on a straight-line basis from the date the agreement was signed on December 13, 2009 through that time. The Company recognized $4.9 million and $5.8 million of revenue for the three and nine months ended March 31, 2010, respectively, which is recorded in License and Milestone Revenue in the accompanying Condensed Statements of Operations and Comprehensive Loss.
Either party may terminate the agreement in the event of a material breach of a material obligation under the agreement by the other party upon 90 days prior notice, and Amgen may terminate the agreement at any time upon notice of 60 or 90 days depending on the development activities going on at the time of such notice. The parties have also agreed to indemnify each other for certain liabilities arising under the agreement.
Celgene Corporation
In September 2007, the Company entered into a worldwide strategic collaboration with Celgene focused on the discovery, development and commercialization of novel therapeutics in cancer and inflammation.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Under the agreement, Celgene made an up-front payment of $40 million to the Company to provide research funding for activities conducted by the Company under the agreement. The Company is responsible for all discovery and clinical development through Phase 1 or Phase 2a. Celgene has an option to select a limited number of drugs developed under the collaboration that are directed to up to two of four mutually selected discovery targets and will receive exclusive worldwide rights to the drugs, except for limited co-promotional rights in the U.S. Celgene’s option may be exercised with respect to drugs directed at any of the four targets at any time until the earlier of completion of Phase 1 or Phase 2a trials for the drug or September 2014. Additionally, the Company is entitled to receive, for each drug for which Celgene exercises an option, potential milestone payments of $200 million, if certain discovery, development and regulatory milestones are achieved and an additional $300 million if certain commercial milestones are achieved. The Company will also receive royalties on net sales of any drugs. The Company retains all rights to the other programs. In June 2009, the parties amended the Celgene agreement to substitute a new discovery target in place of an existing target, and Celgene paid the Company $4.5 million in consideration for the amendment. No other provisions of the agreement with Celgene were modified by the amendment. In September 2009, Celgene notified the Company it was waiving its rights to one of the programs, leaving it the option to select two of the remaining three targets.
The Company had previously estimated that its discovery obligations under the Agreement would continue through September 2014 and accordingly was recognizing as revenue the up front fees received from the date of receipt through September 2014. Effective October 1, 2009, the Company estimated that its discovery efforts under the Agreement will conclude by September 2011 and the Company would complete its obligations at that time. Therefore, the unamortized balance as of September 30, 2009 is being amortized on a straight line basis over the shorter period. The Company recognized $4.1 million and $1.4 million for the three months ended March 31, 2010 and 2009, respectively. The Company recognized $9.8 million and $4.3 million for the nine months ended March 31, 2010 and 2009, respectively. These amounts are recorded in License and Milestone Revenue in the accompanying Condensed Statements of Operations and Comprehensive Loss.
Celgene can also choose to terminate any drug development program for which it has not exercised an option at any time, provided that it must give the Company prior notice. In this event, all rights to the program remain with the Company and it would no longer be entitled to receive milestone payments for further development or regulatory milestones that it could have achieved Celgene had continued development of the program. Celgene may terminate the agreement in whole, or in part with respect to individual drug development programs for which Celgene has exercised its option, upon six months’ written notice to the Company. In addition, either party may terminate the agreement, following certain cure periods, in the event of a breach by the other party of its obligations under the agreement.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
NOTE 5 – LONG-TERM DEBT
Long-term debt consists of the following (dollars in thousands):
 

               
    March 31,     June 30,  
    2010   2009
 
               
Credit facility
    $     126,762       $     86,286  
Refinance term loan
    15,000       -      
Term loan
    -           10,000  
Equipment line of credit
    -           5,000  
 
       
Long-term debt, gross
    141,762       101,286  
Less: Unamortized discount on credit facility
    (30,524 )     (18,116 )  
 
       
Long-term debt, net
    111,238       83,170  
Less: Current portion
    -           (15,000 )
 
       
Long-term debt
    $     111,238       $     68,170  
 
       
Deerfield Credit Facilities
The Company has entered into two credit facilities (the “Credit Facilities”) with Deerfield Private Design Fund, L.P. and Deerfield Private Design International Fund, L.P. (collectively “Deerfield”), health care investment funds. Under a Facility Agreement entered into with Deerfield in April 2008, the Company borrowed a total of $80 million (the “2008 Loan”), which was funded in two $40 million payments in June 2008 and December 2008. Certain terms of the 2008 Credit Facility, including the interest rate and payment terms applicable to the 2008 Loan and covenants relating to minimum cash and cash equivalent balances the Company must maintain, were amended in May 2009 when the Company entered into a new Facility Agreement with Deerfield. Under this Facility Agreement, the Company borrowed $40 million (the “2009 Loan”), which it drew down on July 31, 2009.
Accrued interest on the Credit Facilities is payable monthly, and the outstanding principal and any unpaid accrued interest is due on or before April 2014. Interest and principal may be repaid, at the Company’s option, at any time with shares of the Company’s common stock that have been registered under the Securities Act of 1933, as amended, with certain restrictions, or in cash. The maximum number of shares that the Company can issue to Deerfield under the Credit Facilities is 9,622,220 shares, without obtaining stockholder approval.
Prior to the disbursement of the 2009 Loan, simple interest accrued on the full $80 million principal amount under the 2008 Loan at a 2.0% annual rate and compound interest accrued at an additional 6.5% annual rate. From the date of the Facility Agreement for the 2008 Loan through the July 31, 2009 disbursement date of the 2009 Loan, accrued interest on the 2008 Loan was payable quarterly. The Company made these quarterly interest payments during fiscal 2009 and the first quarter of fiscal 2010. The interest rate on the 2008 Loan was amended upon disbursement of the 2009 Loan on July 31, 2009. As of this date, simple interest began accruing on the $80 million principal balance at the rate of 7.5% per annum, subject to adjustment as described below, and became payable monthly. Compound interest stopped accruing on the 2008 Loan as of July 31, 2009.
Simple interest began to accrue on the 2009 Loan when it was drawn on July 31, 2009 at the rate of 7.5% per annum. This rate will continue to apply as long as the Company’s total Cash and Cash Equivalents and Marketable Securities on the first business day of each month during which such principal amounts remain outstanding is at least $60 million. If the Company’s total Cash and Cash Equivalents and Marketable Securities in any month are less than $60 million, the interest rate is adjusted to a rate

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
between 8.5% per annum and 14.5% per annum for every $10 million by which it is less than $60 million as follows:


 
       
    Applied Interest
Total Cash, Cash Equivalents and Marketable Securities   Rate
 
       
$60 million or greater
    7.5 %
Between $50 million and $60 million
    8.5 %
Between $40 million and $50 million
    9.5 %
Between $30 million and $40 million
    12.0 %
Less than $30 million
    14.5 %
The Credit Facilities contain two embedded derivatives: (1) the variable interest rate structure and (2) Deerfield’s right to accelerate the loan upon certain changes of control of the Company or an event of default, which is considered a significant transaction contingent put option. As discussed in Note 1 “Overview and Basis of Presentation – Long-term Debt and Embedded Derivatives,” these derivatives must be valued and reported separately in the Company’s financial statements, and are collectively referred to as the “Embedded Derivatives.” Under the fair value hierarchy, the Company measured the fair value of the Embedded Derivatives using Level III, or unobservable inputs.
To estimate fair value of the variable interest rate feature, the Company made assumptions as to interest rates that may be in effect during the term and the impact of repaying the debt at maturity in cash and/or stock. Because the variable interest rate feature is tied to the Company’s cash and cash equivalent balances during the term of the Credit Facilities, the Company was also required to project its cash balances over this period, including forecasted up-front revenue from new collaboration arrangements, milestone payments, other revenue, funds to be provided from issuances of debt and/or equity, costs and expenses and other items. Such forecasts are inherently subjective and, although management believes the assumptions upon which they are based are reasonable, may not reflect actual results. Based on this analysis, the Company estimated the effective interest rate over the term of the note will be 7.55% as of July 31, 2009.
To estimate the fair value of the put right, the Company estimated the probability of a change in control that would trigger Deerfield’s acceleration rights as specified in the loan provisions. The Company’s evaluation of this probability was based on its expectations as to the size and financial strength of probable acquirers, including history of collaboration partners, the probability of an acquisition occurring during the term of the Credit Facilities and other factors, all of which are inherently uncertain and difficult to predict. The Company estimated the probability of Deerfield exercising the change in control put to be 5% at July 31, 2009.
Based on these assumptions, the Embedded Derivatives were initially valued as of July 31, 2009 at $1.1 million and recorded as Derivative Liabilities and as Debt Discount in the accompanying Condensed Balance Sheets.
As of each quarter end, the Company re-values the effective interest rate and the probability of the exercise of the change in control put. The assumptions used at July 31, 2009, described above, did not change at September 30, 2009, and the estimated fair value of the Embedded Derivatives was determined to be $938 thousand. The assumptions used at December 31, 2009 changed nominally for the effective interest rate to 7.54% and remained at 5% for the probability of the exercise of the change of control put. The estimated fair value of the Embedded Derivatives was determined to be $857 thousand as of December 31, 2009. The assumptions used at March 31, 2010 remained at 7.54% for the effective interest rate and at 5% for the probability of the exercise of the change of control put. The estimated fair

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
value of the Embedded Derivatives based on these assumptions was determined to be $863 thousand as of March 31, 2010.
The change in value of the Embedded Derivatives of $7 thousand and $(199) thousand was recorded as an increase (reduction) to Interest Expense in the accompanying Statements of Operations and Comprehensive Loss for the three and nine months ended March 31, 2010, respectively. Management will re-assess these assumptions at each reporting date, and future changes to these assumptions could materially change the estimated fair value of the Embedded Derivatives, with a corresponding impact on the Company’s reported results of operations.
The Company estimated that the fair value of the Deerfield debt was $92.2 million and $48.7 million at March 31, 2010 and June 30, 2009, respectively. The primary reason for the difference in fair value is that the Company had drawn only $80 million of the total $120 million under the Credit Facilities as of June 30, 2009.
The Company paid Deerfield transaction fees totaling $2 million when the Company drew the funds under the 2008 Loan, and $500 thousand on July 10, 2009 and $500 thousand when the funds were drawn under the 2009 Loan. The transaction fees are included in Other Long-term Assets in the accompanying Condensed Balance Sheets. The Company is amortizing these transaction fees to Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss over the respective terms of each of the Credit Facilities. Other direct issuance costs in connection with the transactions were expensed as incurred and were not significant.
The Credit Facilities are secured by a second priority security interest in the Company’s assets, including accounts receivable, equipment, inventory, investment property and general intangible assets, excluding copyrights, patents, trademarks, service marks and certain related intangible assets. This security interest and the Company’s obligations under the Credit Facilities are subordinate to the Company’s obligations to Comerica Bank, and to Comerica’s security interest, under the Loan and Security Agreement between the Company and Comerica Bank dated June 28, 2005, as amended, discussed below.
The Facility Agreements for both Credit Facilities contain representations, warranties and affirmative and negative covenants that are customary for credit facilities of this type. The Facility Agreements restrict the Company’s ability to, among other things, sell certain assets, engage in a merger or change in control transaction, incur debt, pay cash dividends and make investments. The Facility Agreements also contain events of default that are customary for credit facilities of this type, including payment defaults, covenant defaults, insolvency type defaults and events of default relating to liens, judgments, material misrepresentations and the occurrence of certain material adverse events. In addition, if the Company’s total Cash, Cash Equivalents and Marketable Securities at the end of a fiscal quarter fall below $20 million (which was reduced from $40 million when the Company entered into the 2009 Credit Facility), all amounts outstanding under the Credit Facilities become immediately due and payable. The Company is also required, subject to certain exceptions and conditions, to make payments of principal equal to 15.0% of certain amounts it receives under collaboration, licensing, partnering, joint venture and other similar arrangements entered into after January 1, 2011.
Warrants Issued to Deerfield
In consideration for providing the 2008 Credit Facility, the Company issued warrants to Deerfield to purchase 6,000,000 shares of Common Stock at an exercise price of $7.54 per share (the “Prior Warrants”). Pursuant to the terms of the Facility Agreement for the 2009 Loan, the Prior Warrants were terminated and the Company issued new warrants to Deerfield to purchase 6,000,000 shares of Common Stock at an exercise price of $3.65 (the “Exchange Warrants”). The Company also issued Deerfield warrants to purchase an aggregate of 6,000,000 shares of the Company’s Common Stock at an exercise price of $4.19 (the “New Warrants” and collectively with the Exchange Warrants, the “Warrants”) when the funds were disbursed on July 31, 2009.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
The Exchange Warrants contain substantially the same terms as the Prior Warrants, except that the Exchange Warrants did not become exercisable until January 31, 2010 and have a lower per share exercise price. The Warrants are exercisable commencing January 31, 2009 and expire on April 29, 2014. Other than the exercise price, all other provisions of the Exchange Warrants and the New Warrants are identical.
The Company allocated the $80 million proceeds under the 2008 Loan between the debt and the Prior Warrants based upon their estimated relative fair values. The Company valued the Prior Warrants using the Black-Scholes option pricing model using the following assumptions:
    Risk-free interest rate of 3.3%;
 
    Volatility of 63.9%;
 
    Expected life of six years; and
 
    Dividend yield of zero.
The Company allocated $20.6 million in value to equity and recorded it as Debt Discount in the accompanying Condensed Balance Sheets. Because the 2008 Loan was drawn down in two separate tranches, the Company is amortizing half of the Prior Warrant value from the first draw date and the remaining half from the second draw date, in both cases to the end of the credit facility term, to Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss.
The Company allocated the $40 million proceeds under the 2009 Loan between the debt and the New Warrants based upon their estimated relative fair values. The Company valued the New Warrants using the Black-Scholes option pricing model using the following assumptions:
    Risk-free interest rate of 2.46%;
 
    Volatility of 63.59%;
 
    Expected life of five years; and
 
    Dividend yield of zero.
The Company allocated $12.4 million in value to equity and recorded it as Debt Discount. The Company is amortizing the discount from the July 31, 2009 draw date to the end of the Credit Facility term to Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss.
The Company calculated the incremental value of the Exchange Warrants as the difference between the value of the Exchange Warrants at the new exercise price of $3.65 and the value of the Prior Warrants at the prior exercise price of $7.54. The Black-Scholes option pricing models used to calculate these values used the following assumptions:
    Risk-free interest rate of 1.86%;
 
    Volatility of 61.94%;
 
    Expected life of five years; and
 
    Dividend yield of zero.
Prior to disbursement of the 2009 Loan, the Company recorded the incremental value of the Exchange Warrants of $3.3 million as of June 30, 2009 in Other Long-Term Assets and Warrants in the accompanying Condensed Balance Sheets. Following disbursement of the 2009 Loan on July 31, 2009, the Company reclassified the balance in Other Long-Term Assets to Debt Discount and began amortizing the discount to Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss from July 31, 2009 to the end of the term of the Credit Facilities.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
A reconciliation of the total interest expense recognized by the Company for the Deerfield Credit Facilities for the three and nine months ended March 31, 2010 and 2009 follows (dollars in thousands).

 
                                 
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
 
                               
2.0% simple interest
    $     -           $     395       $     124       $     1,201  
6.5% compounding interest
    -           1,339       476       4,012  
7.5% simple interest
    2,250       -           6,000       -      
Amortization of the transaction fees
    140       795       408       1,612  
Amortization of the debt discounts
    1,538       88       4,362       180  
Change in value of the Embedded Derivatives
    7       -           (199 )     -      
 
               
Total interest expense on the Deerfield Credit Facility
    $     3,935       $     2,617       $     11,171       $     7,005  
 
               
Term Loan and Equipment Line of Credit
The Company entered into a Loan and Security Agreement (“Loan and Security Agreement”) with Comerica Bank dated June 28, 2005, which was has been subsequently amended. The Loan and Security Agreement provides for a term loan, equipment advances and a revolving line of credit, all of which are secured by a first priority security interest in the Company’s assets, other than its intellectual property.
The full $10 million term loan was advanced to the Company on June 30, 2005. The Company received the total $5 million of equipment advances by June 30, 2007.
On September 30, 2009, the term and the interest rate structure of the Loan and Security Agreement were amended. The maturity date was extended 120 days from June 28, 2010 to October 26, 2010. Effective October 1, 2009, the outstanding balances under the term loan and the equipment advances accrued interest on a monthly basis at a rate equal to 2.75% above the Prime Rate, as quoted by Comerica Bank, but not less than the sum of Comerica Bank’s daily adjusting LIBOR rate plus 2.5% per annum.
On March 31, 2010, the term and interest rate structure of the Loan and Security Agreement were amended. The term loan and equipment advances were also combined into one instrument referred to as the Refinance Term Loan. The maturity date was extended three years from October 26, 2010 to October 26, 2013. Effective April 1, 2010, the outstanding balances under the term loan and the equipment advances will bear interest on a monthly basis at the Prime Rate, as quoted by Comerica Bank, but will not be less than the sum of Comerica Bank’s daily adjusting LIBOR rate plus an incremental contractually predetermined rate. This rate is variable, ranging from the Prime Rate to the Prime Rate plus 4.0%, based on the total dollar amount the Company has invested at Comerica and in what investment option those funds are invested.
In addition, total available revolving lines of credit of $6.8 million have been established to support outstanding standby letters of credit in relation to the Company’s facilities leases. These standby letters of credit expire on January 31, 2014 and August 31, 2016.
As of March 31, 2010, the Refinance Term Loan had an interest rate of 3.25% per annum. The Company recognized $217 thousand and $57 thousand of interest for the three months ended March 31, 2010 and 2009, respectively. The Company recognized $514 thousand and $284 thousand of interest for the nine months ended March 31, 2010 and 2009, respectively. These charges are recorded in Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss.
The following table outlines the level of Cash, Cash Equivalents and Marketable Securities the Company must hold in accounts at Comerica Bank per the Loan and Security Agreement based on the Company’s

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
total Cash, Cash Equivalent and Marketable Securities, which was modified as part of the March 31, 2010 amendment.

 
        
    Cash on Hand
Total Cash, Cash Equivalents and Marketable Securities   at Comerica
 
       
Greater than $40 million
    $    -      
Between $25 million and $40 million
    $    10,000,000  
Less than $25 million
    $    22,000,000  
The Loan and Security Agreement contains representations and warranties and affirmative and negative covenants that are customary for credit facilities of this type. The Loan and Security Agreement restricts the Company’s ability to, among other things, sell certain assets, engage in a merger or change in control transaction, incur debt, pay cash dividends and make investments. The Loan and Security Agreement also contains events of default that are customary for credit facilities of this type, including payment defaults, covenant defaults, insolvency type defaults and events of default relating to liens, judgments, material misrepresentations and the occurrence of certain material adverse events.
The estimated fair value of the Loan and Security Agreement was $15.0 million and $14.3 million as of March 31, 2010 and June 30, 2009, respectively.
Commitment Schedule
A summary of the Company’s contractual commitments as of March 31, 2010 under the Credit Facilities and the Loan and Security Agreement discussed above are as follows (dollars in thousands):

 
       
For the twelve months ended March 31,      
2011
    $      -      
2012
    -      
2013
    -      
2014
    15,000  
2015
    126,762  
 
   
 
    $      141,762  
 
   
NOTE 6 – NET LOSS PER SHARE
As a result of the Company’s net losses for the three-month periods ended March 31, 2010 and 2009 all potentially dilutive securities were anti-dilutive and therefore have been excluded from the computation of diluted net loss per share. As of March 31, 2010 and 2009, the number of potentially dilutive common stock equivalents excluded from the diluted net loss per share calculations was 1,303,485 shares and 440,659 shares, respectively.
NOTE 7 – SHARE BASED COMPENSATION EXPENSE
The Company adopted the modified prospective method for expensing share-based compensation as of July 1, 2005, which requires that all share-based payments to employees be recognized in the

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
Condensed Statements of Operations and Comprehensive Loss at the fair value of the award on the grant date. Under this method, the Company recognizes compensation expense equal to the grant date fair value for all share-based payments (i) granted prior to, but not yet vested, as of July 1, 2005 and (ii) granted on or after July 1, 2005. Shared-based compensation arrangements include stock option grants under the Option Plan and purchases of common stock at a discount under the ESPP. The fair value of all stock options granted by the Company is estimated on the date of grant using the Black-Scholes option pricing model. The Company recognizes share-based compensation expense on a straight-line basis over the vesting term of stock option grants. See Note 13 “Employee Compensation Plans” to the Company’s audited financial statements included in its Annual Report on Form 10-K for the year ended June 30, 2009 for more information about the assumptions used by the Company under this valuation methodology. During the three and nine months ended March 31, 2010, the Company made no material changes to these assumptions.
During the three months ended March 31, 2010 and 2009, the Company issued new stock options to purchase a total of 939 thousand shares and 18 thousand shares of common stock, respectively. The Company recognized compensation expense related to stock options of $1.0 million and $1.3 million for the three months ended March 31, 2010 and 2009, respectively.
During the nine months ended March 31, 2010 and 2009, the Company issued new stock options to purchase a total of 1.2 million shares and 1.3 million shares of common stock, respectively. The Company recognized compensation expense related to stock options of $3.6 million and $4.0 million for the nine months ended March 31, 2010 and 2009, respectively.
As of March 31, 2010, there was $5.9 million of total unrecognized compensation expense, including the impact of expected forfeitures, related to unvested share-based compensation awards granted under the Company’s equity plans, which the Company expects to recognize over a weighted-average period of 2.4 years.
The fair value of common stock purchased under the ESPP is based on the estimated fair value of the common stock during the offering period and the percentage of the purchase discount. During the three months ended March 31, 2010 and 2009, the Company recognized compensation expense related to its ESPP of $178 thousand and $193 thousand, respectively. During the nine months ended March 31, 2010 and 2009, the Company recognized compensation expense related to its ESPP of $608 thousand and $579 thousand, respectively.
NOTE 8 – EQUITY DISTRIBUTION AGREEMENT
On September 18, 2009, the Company entered into an Equity Distribution Agreement with Piper Jaffray & Co. (the “Agent”) pursuant to which the Company agreed to sell from time to time, up to an aggregate of $25 million in shares of its $.001 par value common stock, through the Agent that have been registered on a registration statement on Form S-3 (File No. 333-15801). Sales of the shares made pursuant to the Equity Distribution Agreement, if any, will be made on the NASDAQ Stock Market by means of ordinary brokers’ transactions at market prices. Additionally, under the terms of the Equity Distribution Agreement, the Company may sell shares of its common stock through the Agent, on the NASDAQ Global Market or otherwise, at negotiated prices or at prices related to the prevailing market price.
During the three months ended March 31, 2010, the Company sold 544,126 shares of common stock at an average price of $2.60 per share, and received gross proceeds of $1.4 million. The Company paid commissions to the Agent relating to these sales equal to $42 thousand and other expenses relating to the closing of the Equity Distribution Agreement totaling $21 thousand.
During the nine months ended March 31, 2010, the Company sold 1,300,816 shares of common stock at an average price of $2.72 per share, and received gross proceeds of $3.5 million. The Company paid commissions to the Agent relating to these sales equal to $106 thousand and other expenses relating to the closing of the Equity Distribution Agreement totaling $264 thousand.

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ARRAY BIOPHARMA INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
For the quarter ended March 31, 2010
(Unaudited)
NOTE 9 – EMPLOYEE BONUS
On October 5, 2009, the Company paid bonuses to approximately 350 eligible employees having an aggregate value of $3.9 million under the fiscal 2009 Performance Bonus Program through the issuance of a total of 1,000,691 shares of its common stock valued at $2.4 million and payment of cash to satisfy related withholding taxes. The liability for the bonus as of June 30, 2009 is recorded in Accrued Compensation and Benefits in the accompanying Condensed Balance Sheets.
NOTE 10 – SUBSEQUENT EVENT
The Company and Novartis International Pharmaceutical Ltd. entered into a License Agreement in April 2010 (the “Agreement”) granting Novartis the exclusive worldwide right to co-develop and commercialize MEK162 (ARRY-162), currently in a Phase 1 cancer trial, and MEK300 (ARRY-300), as well as other specified MEK inhibitors. Under the Agreement, the Company is responsible for completing the on-going Phase 1 clinical trial of MEK162 and the further development of MEK162 for up to two indications. Novartis is responsible for all other development activities and for the commercialization of products under the Agreement, subject to the Company’s option to co-detail approved drugs in the United States.
In consideration for the rights granted to Novartis under the Agreement, the Company will initially receive $45 million, comprising an upfront and milestone payment, in the fourth quarter of fiscal 2010 and is also entitled to receive up to approximately $422 million in aggregate milestone payments if all clinical, regulatory and commercial milestones specified in the Agreement are achieved. The Company is entitled to receive additional commercial milestone payments for MEK300, and for other MEK inhibitors. Novartis will also pay the Company royalties on worldwide sales of any approved drugs, with royalties on U.S. sales at a significantly higher level. The Company will pay a percentage of development costs up to a maximum amount with annual caps. The Company may opt out of paying its share of development costs with respect to one or more products; in this event, the U.S. royalty rate would then be reduced for any such product based on a specified formula, subject to a minimum that equals the royalty rate on sales outside the United States, and the Company would no longer have the right to develop or detail such product.
The Agreement will be in effect on a product-by-product and county-by-country basis until no further payments are due with respect to the applicable product in the applicable country, unless terminated earlier. Either party may terminate the Agreement in the event of an uncured material breach of a material obligation under the Agreement by the other party upon 90 days prior notice. Novartis may terminate portions of the Agreement following a change in control of the Company and may terminate the Agreement in its entirety or on a product-by-product basis with 180 days prior notice. The Company and Novartis have each further agreed to indemnify the other party for manufacturing or commercialization activities conducted by it under the Agreement, negligence or willful misconduct or breach of covenants, warranties or representations made by it under the Agreement.

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ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
RESULTS OF OPERATIONS
Management’s Discussion and Analysis of Financial Condition and Results of Operations contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements about our expectations related to the progress and success of drug discovery activities conducted by us and by our collaborators, our ability to obtain additional capital to fund our operations and/or reduce our research and development spending, realizing new revenue streams and obtaining future out-licensing collaboration agreements that include up-front milestone and/or royalty payments, our ability to realize up-front milestone and royalty payments under our existing or any future agreements, future research and development spending and projections relating to the level of cash we expect to use in operations, our working capital requirements and our future headcount requirements. In some cases, forward-looking statements can be identified by the use of terms such as “may,” “will,” “expects,” “intends,” “plans,” “anticipates,” “estimates,” “potential,” or “continue,” or the negative thereof or other comparable terms. These statements are based on current expectations, projections and assumptions made by management and are not guarantees of future performance. Although we believe that the expectations reflected in the forward-looking statements contained herein are reasonable, these expectations or any of the forward-looking statements could prove to be incorrect, and actual results could differ materially from those projected or assumed in the forward-looking statements. Our future financial condition, as well as any forward-looking statements are subject to significant risks and uncertainties, including but not limited to the factors set forth under the heading “Risk Factors” in Part II, Item 1A of this Quarterly Report on Form 10-Q and Item 1A of our Annual Report on Form 10-K for the fiscal year ended June 30, 2009. All forward looking statements are made as of the date hereof, and, unless required by law, we undertake no obligation to update any forward-looking statements.
The following discussion of our financial condition and results of operations should be read in conjunction with the financial statements and notes to those statements included elsewhere in this quarterly report. The terms “we,” “us,” “our” and similar terms refer to Array BioPharma Inc.
Overview
We are a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer and inflammatory diseases. Our proprietary drug development pipeline includes clinical candidates that are designed to regulate therapeutically important target proteins. In addition, leading pharmaceutical and biotechnology companies partner with us to discover and develop drug candidates across a broad range of therapeutic areas.
The five most advanced wholly-owned programs in our development pipeline as of March 31, 2010 are as follows:
  1.   MEK162, a MEK inhibitor for cancer
 
  2.   ARRY-380, a HER2 inhibitor for breast cancer
 
  3.   ARRY-520, a KSP inhibitor for acute myeloid leukemia, or AML, and multiple myeloma, or MM
 
  4.   ARRY-614, a p38/Tie 2 dual inhibitor for myelodysplastic syndrome, or MDS
 
  5.   ARRY-543, a HER2/EGFR inhibitor for solid tumors
In addition to these proprietary development programs, the seven most advanced partnered drugs in clinical development as of March 31, 2010 are as follows:
  1.   AMG 151 / ARRY-403, a glucokinase activator for Type 2 diabetes, partnered with Amgen Inc.
 
  2.   AZD6244, a MEK inhibitor for cancer, partnered with AstraZeneca, PLC
 
  3.   AZD8330, a MEK inhibitor for cancer, partnered with AstraZeneca, PLC

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  4.   RG7227/ITMN-191, a hepatitis C virus (HCV) protease inhibitor danoprevir, partnered with InterMune, Inc./Roche Holding AG
 
  5.   LY2603618/IC83, a Chk inhibitor for cancer, partnered with Eli Lilly and Company
 
  6.   VTX-2337, a Toll-like receptor for cancer, partnered with VentiRx Pharmaceuticals, Inc.
 
  7.   VTX-1463, a Toll-like receptor for allergy, partnered with VentiRx Pharmaceuticals, Inc.
We also have a portfolio of proprietary and partnered drug discovery programs that we believe will generate an average of one to two Investigational New Drug, or IND, applications per year. Our discovery efforts have also generated additional early-stage drug candidates and we may choose to out-license select promising candidates through research partnerships prior to filing an IND application.
We have built our proprietary pipeline of research and development programs on spending of $403.2 million from our inception through March 31, 2010. Although we continue to commit significant resources to create our own proprietary drug candidates and to build a commercial-stage biopharmaceutical company, due to ongoing uncertainty in the capital markets as well as general economic conditions that have negatively affected the biopharmaceutical market, we reduced our spending on our proprietary discovery and development programs to focus on advancing our most promising clinical programs through proof-of-concept, which we believe will maximize their value, and, on our most promising discovery candidates. In the third quarter of fiscal 2010, our spending on research and development for proprietary drug discovery was $17.7 million, down from $20.0 million for the same quarter in fiscal 2009. In the first nine months of fiscal 2010 and 2009, our spending on research and development for proprietary drug discovery was $56.0 million and $68.2 million, respectively. In fiscal 2009, we spent $89.6 million in research and development for proprietary drug discovery expenses, as compared to $90.3 million and $57.5 million for fiscal years 2008 and 2007, respectively.
As part of our efforts to conserve our capital resources, we reduced our workforce in January 2009 by approximately 40 employees, or 10%, who were primarily in discovery research and support positions, resulting in a restructuring charge of approximately $1.5 million in the third quarter of fiscal 2009. We are also accelerating our efforts to partner select discovery and development programs that will provide funding, development and commercial resources, with the goal of optimizing the value of our drug portfolio.
We have received a total of $426.6 million in research funding and in up-front and milestone payments from our collaboration partners through March 31, 2010. Under our existing collaboration agreements as of March 31, 2010, we have the potential to earn up to over $2.0 billion in additional milestone payments if we or our collaborators achieve all the drug discovery objectives detailed in those agreements, as well as the potential to earn royalties on any resulting product sales from 16 drug development programs.
Our significant collaborators as of March 31, 2010 include:
    Amgen Inc., which entered into a worldwide strategic collaboration with us to develop and commercialize our glucokinase activator, AMG 151 / ARRY-403.
 
    Genentech, Inc., which entered into a worldwide strategic collaboration agreement with us focused on the discovery, development and commercialization of novel therapeutics.
 
    Celgene Corporation, which entered into a worldwide strategic collaboration agreement with us focused on the discovery, development and commercialization of novel therapeutics in cancer and inflammation.
 
    AstraZeneca, which licensed three of our MEK inhibitors for cancer, including AZD6244 (ARRY-886), which is currently in multiple Phase 2 clinical trials.
 
    InterMune, Inc., which collaborated with us on the discovery of RG7227/ITMN-191, a novel small molecule inhibitor of the Hepatitis C Virus NS3/4 protease. InterMune and its development partner, Roche, have reported that they are currently advancing the drug in a Phase 2b trial evaluating ITMN-191 in combination with standard of care therapies.

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Our fiscal year ends on June 30. When we refer to a fiscal year or quarter, we are referring to the year in which the fiscal year ends and the quarters during that fiscal year. Therefore, fiscal 2010 refers to the fiscal year ended June 30, 2010 and the third quarter of fiscal 2010 refers to the three months ended March 31, 2010.
Business Development and Collaborator Concentrations
We currently license or partner certain of our compounds and/or programs and enter into collaborations directly with pharmaceutical and biotechnology companies through opportunities identified by our business development group, senior management, scientists and customer referrals. In addition, we may license our compounds and enter into collaborations in Japan through an agent.
The following collaborators contributed greater than 10% of total revenue for the three and nine months ended March 31, 2010 and 2009:

 
                                 
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
 
                               
Amgen Inc.
    34.7 %       0.0 %       20.3 %       0.0 %  
Celgene Corporation
    22.5 %       23.7 %       27.5 %       22.0 %  
Genentech, Inc.
    42.1 %       70.6 %       48.0 %       66.4 %  
 
               
 
    99.3 %       94.3 %       95.8 %       88.4 %  
 
               
In general, certain of our collaborators may terminate their collaboration agreements with 90 to 180 days’ prior notice. Our agreement with Genentech can be terminated with 120 days’ notice. Celgene may terminate its agreement with us with six months’ notice. Amgen may terminate its agreement with us at any time upon notice of 60 or 90 days depending on the development activities going on at the time of such notice.
The following table details revenue from our collaborators by region based on the country in which collaborators are located or the ship-to destination for compounds (dollars in thousands):

 
                                 
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
 
                               
North America
    $     18,310       $     6,005       $     35,706       $     19,111  
Europe
    52       25       161       333  
Asia Pacific
    14       8       43       30  
 
               
 
    $     18,376       $     6,038       $     35,910       $     19,474  
 
               
All of our collaboration agreements are denominated in U.S. dollars.

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Critical Accounting Policies and Estimates
Management’s discussion and analysis of financial condition and results of operations are based upon our accompanying Condensed Financial Statements, which have been prepared in accordance with accounting principles generally accepted in the U.S. The preparation of these financial statements requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue and expenses as well as the disclosure of contingent assets and liabilities. We regularly review our estimates and assumptions. These estimates and assumptions, which are based upon historical experience and on various other factors believed to be reasonable under the circumstances, form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Reported amounts and disclosures may have been different had management used different estimates and assumptions or if different conditions had occurred in the periods presented.
Below is a discussion of the policies and estimates that we believe involve a high degree of judgment and complexity.
Fair Value Measurements
Our financial instruments are recognized and measured at fair value in our financial statements and mainly consist of cash and cash equivalents, marketable securities, long-term investments, trade receivables and payables, accrued outsourcing costs, accrued expenses, long-term debt, embedded derivatives associated with the long-term debt, and warrants. We use different valuation techniques to measure the fair value of assets and liabilities, as discussed in more detail below. Fair value is defined as the price that would be received to sell the financial instruments in an orderly transaction between market participants at the measurement date. We use a framework for measuring fair value based on a hierarchy that distinguishes sources of available information used in fair value measurements and categorizes them into three levels:
             
 
    Level I:   Quoted prices in active markets for identical assets and liabilities.
 
    Level II:   Observable inputs other than quoted prices in active markets for identical assets and liabilities.
 
    Level III:   Unobservable inputs.
We disclose assets and liabilities measured at fair value based on their level in the hierarchy. Considerable judgment is required in interpreting market data to develop estimates of fair value for assets or liabilities for which there are no quoted prices in active markets, which include our auction rate securities, or ARS, warrants issued by us or embedded derivatives associated with our long-term debt. The use of different assumptions and/or estimation methodologies may have a material effect on their estimated fair value. Accordingly, the fair value estimates disclosed by us may not be indicative of the amount that we or holders of the instruments could realize in a current market exchange.
We periodically review the realizability of each investment when impairment indicators exist with respect to the investment. If an other-than-temporary impairment of the value of an investment is deemed to exist, the carrying value of the investment is written down to its estimated fair value.
Long-term Debt and Embedded Derivatives
The terms of our long-term debt are discussed in detail in Note 5 “Long-term Debt.” The accounting for these arrangements is complex and is based upon significant estimates by management. We review all debt agreements to determine the appropriate accounting treatment when the agreement is entered into, and review all amendments to determine if the changes require accounting for the amendment as a modification, or extinguishment and new debt. We also review each long-term debt arrangement to determine if any feature of the debt requires bifurcation and/or separate valuation. These features include

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hybrid instruments, which are comprised of at least two components ((1) a debt host instrument and (2) one or more conversion features), warrants and other embedded derivatives, such as puts and other rights of the debt holder.
We currently have two embedded derivatives related to our long-term debt with Deerfield Private Design Fund, L.P. and Deerfield Private Design International Fund, L.P. (who we refer to collectively as Deerfield). The first is a variable interest rate structure that constitutes a liquidity-linked variable spread feature. The second derivative is a significant transaction contingent put option relating to the ability of Deerfield to accelerate repayment of the debt in the event of certain changes in control of our company. Collectively, they are referred to as the “Embedded Derivatives.” Under the fair value hierarchy, our Embedded Derivatives are measured using Level III, or unobservable inputs, as there is no active market for them. The fair value of the variable interest rate structure is based on our estimate of the probable effective interest rate over the term of the Deerfield credit facilities. The fair value of the put option is based on our estimate of the probability that a change in control that triggers Deerfield’s right to accelerate the debt will occur. With those inputs, the fair value of each Embedded Derivative is calculated as the difference between the fair value of the Deerfield credit facilities if the Embedded Derivatives are included, and the fair value of the Deerfield credit facilities if the Embedded Derivatives are excluded. Due to the inherent complexity in valuing the Deerfield credit facilities and the Embedded Derivatives, we engaged a third-party valuation firm to perform the valuation as of July 31, 2009, the date funds were disbursed under the credit facility entered into in May 2009, and as of September 30, 2009 and March 31, 2010. The estimated fair value of the Embedded Derivatives was determined based on management’s judgment and assumptions, and the use of different assumptions could result in significantly different estimated fair values.
The fair value of the Embedded Derivatives was initially recorded as Derivative Liabilities and as Debt Discount in our Condensed Balance Sheets. Any change in the value of the Embedded Derivatives is adjusted quarterly as appropriate and recorded to Derivative Liabilities in the Condensed Balance Sheets and Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss. The Debt Discount is being amortized from the draw date of July 31, 2009 to the end of the term of the Deerfield credit facilities using the effective interest method and recorded as Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss.
Warrants we issue in connection with our long-term debt arrangements are reviewed to determine if they should be classified as liabilities or as equity. All outstanding warrants issued by us have been classified as equity. We value the warrants at issuance based on a Black-Scholes option pricing model and then allocate a portion of the proceeds under the debt to the warrants based upon their relative fair values.
Any transaction fees paid in connection with our long-term debt arrangements are recorded as Other Long-Term Assets in the Condensed Balance Sheets and amortized to Interest Expense in the accompanying Condensed Statements of Operations and Comprehensive Loss using the effective interest method over the term of the underlying debt agreement.
Marketable Securities
We have designated our marketable securities as of March 31, 2010 and June 30, 2009 as available-for-sale securities and account for them at their respective fair values. Marketable securities are classified as short-term or long-term based on the nature of these securities and the availability of these securities to meet current operating requirements. Marketable securities that are readily available for use in current operations are classified as short-term available-for-sale securities and are reported as a component of current assets in the accompanying Condensed Balance Sheets. Marketable securities that are not considered available for use in current operations are classified as long-term available-for-sale securities and are reported as a component of long-term assets in the accompanying Condensed Balance Sheets.

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Securities that are classified as available-for-sale are carried at fair value, including accrued interest, with temporary unrealized gains and losses reported as a component of Stockholders’ Deficit until their disposition. We review all available-for-sale securities each period to determine if they will remain available-for-sale based on our current intent and ability to sell the security if we are required to do so. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization is included in Interest Income in the accompanying Condensed Statements of Operations and Comprehensive Loss. Realized gains and losses are reported in Interest Income and Interest Expense, respectively, in the accompanying Condensed Statements of Operations and Comprehensive Loss as incurred. Declines in value judged to be other-than-temporary are reported in Impairment of Marketable Securities in the accompanying Condensed Statements of Operations and Comprehensive Loss as recognized. The cost of securities sold is based on the specific identification method.
Under the fair value hierarchy, our ARS are measured using Level III, or unobservable inputs, as there is no active market for the securities. The most significant unobservable inputs used in this method are estimates of the amount of time until a liquidity event will occur and the discount rate, which incorporates estimates of credit risk and a liquidity premium (discount). Due to the inherent complexity in valuing these securities, we engaged a third-party valuation firm to perform an independent valuation of the ARS beginning with the first quarter of fiscal 2009 and continuing through the current fiscal quarter. While we believe that the estimates used in the fair value analysis are reasonable, a change in any of the assumptions underlying these estimates would result in different fair value estimates for the ARS and could result in additional adjustments to the ARS, either increasing or further decreasing their value, possibly by material amounts.
See Note 3 “Marketable Securities” for additional information about our investments in ARS as well as “Other Income (Expense)” in the Results of Operations discussion in Management’s Discussion and Analysis of Financial Condition and Results of Operations included elsewhere in this Quarterly Report on Form 10-Q.
Accrued Outsourcing Costs
Substantial portions of our preclinical studies and clinical trials are performed by third-party laboratories, medical centers, contract research organizations, and other vendors (collectively “CROs”). These CROs generally bill monthly or quarterly for services performed or bill based upon milestone achievement. For preclinical studies, we accrue expenses based upon estimated percentage of work completed and the contract milestones remaining. For clinical studies, expenses are accrued based upon the number of patients enrolled and the duration of the study. We monitor patient enrollment, the progress of clinical studies and related activities to the extent possible through internal reviews of data reported to us by the CROs, correspondence with the CROs and clinical site visits. Our estimates depend on the timeliness and accuracy of the data provided by the CROs regarding the status of each program and total program spending. We periodically evaluate our estimates to determine if adjustments are necessary or appropriate based on information we receive.
Revenue Recognition
Most of our revenue is from our collaborators for research funding, up-front or license fees and milestone payments derived from discovering and developing drug candidates. Our agreements with collaboration partners include fees based on contracted annual rates for full-time-equivalent employees working on a program, and may also include non-refundable license and up-front fees, non-refundable milestone payments that are triggered upon achievement of specific research or development goals, and future royalties on sales of products that result from the collaboration. A small portion of our revenue comes from the sale of compounds on a per-compound basis. We report revenue for discovery research funding, the sale of chemical compounds and the co-development of proprietary drug candidates we out-license, as

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Collaboration Revenue. License and Milestone Revenue is combined and consists of the current period’s recognized up-front fees and ongoing milestone payments from collaborators.
We recognize revenue in accordance with Staff Accounting Bulletin No. 104, Revenue Recognition (“SAB 104”). SAB 104 establishes four criteria, each of which must be met, in order to recognize revenue related to the performance of services or the shipment of products. Revenue is recognized when (a) persuasive evidence of an arrangement exists, (b) products are delivered or services are rendered, (c) the sales price is fixed or determinable, and (d) collectability is reasonably assured.
Collaboration agreements that include a combination of discovery research funding, up-front or license fees, milestone payments and/or royalties are evaluated to determine whether each deliverable under the agreement has value to the customer on a stand-alone basis and whether reliable evidence of fair value for the deliverable exists. Deliverables in an arrangement that do not meet the separation criteria are treated as a single unit of accounting, generally applying applicable revenue recognition guidance for the final deliverable to the combined unit of accounting in accordance with SAB 104.
We recognize revenue from non-refundable up-front payments and license fees on a straight-line basis over the term of performance under the agreement, which is generally the estimated research term. These advance payments are deferred and recorded as Deferred Revenue upon receipt, pending recognition, and are classified as a short-term or long-term liability in the accompanying Condensed Balance Sheets. When the performance period is not specifically identifiable from the agreement, we estimate the performance period based upon provisions contained within the agreement, such as the duration of the research term, the specific number of full-time-equivalent scientists working a defined number of hours per year at a stated price under the agreement, the existence, or likelihood of achievement, of development commitments, and other significant commitments of ours.
We also have agreements that provide for milestone payments. In certain cases, a portion of each milestone payment is recognized as revenue when the specific milestone is achieved based on the applicable percentage of the estimated research or development term that has elapsed to the total estimated research and/or development term. In other cases, when the milestone payment finances the future development obligations of the Company, the revenue is recognized on a straight-line basis over the estimated remaining development period. Certain milestone payments are related to activities for which there are no future obligations, and as a result, are recognized when earned in their entirety.
We periodically review the expected performance periods under each of our agreements that provide for non-refundable up-front payments and license fees and milestone payments and adjusts the amortization periods when appropriate to reflect changes in assumptions relating to the duration of expected performance periods. Revenue recognition related to non-refundable license fees and up-front payments and to milestone payments could be accelerated in the event of early termination of programs or alternatively, decelerated, if programs are extended.
Cost of Revenue and Research and Development Expenses for Proprietary Drug Discovery
We incur costs in connection with performing research and development activities which consist mainly of compensation, associated fringe benefits, share-based compensation, preclinical and clinical outsourcing costs and other collaboration-related costs, including supplies, small tools, facilities, depreciation, recruiting and relocation costs and other direct and indirect chemical handling and laboratory support costs. We allocate most of these costs between Cost of Revenue and Research and Development Expenses for Proprietary Drug Discovery based upon the respective time spent by our scientists on our collaborations and for our internal proprietary programs, respectively. Preclinical and clinical outsourcing costs are charged directly to the collaboration program. Cost of Revenue represents the costs associated with research and development, including preclinical and clinical trials, conducted by us for our collaborators. Research and Development Expenses for Proprietary Drug Discovery consist of direct and indirect costs related to specific proprietary programs. We do not bear any risk of failure for performing

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these activities and the payments are not contingent on the success or failure of the research program. Accordingly, we expense these costs when incurred.
Where our collaboration agreements provide for us to conduct research or development, and for which our partner has an option to obtain the right to conduct further development and to commercialize a product, we attribute a portion of its research and development costs to Cost of Revenue based on the percentage of total programs under the agreement that we conclude is likely to be selected by the partner. These costs may not be incurred equally across all programs. In addition, we continually evaluate the progress of development activities under these agreements and if events or circumstances change in future periods that we reasonably believe would make it unlikely that a collaborator would exercise an option with respect to the same percentage of programs, we will adjust the allocation accordingly.
For example, we granted Celgene Corporation an option to select up to two of four programs developed under our collaboration agreement with Celgene and concluded that Celgene was likely to exercise its option with respect to two of the four programs. Accordingly, we reported costs associated with the Celgene collaboration as follows: 50% to Cost of Revenue, with the remaining 50% to Research and Development Expenses for Proprietary Drug Discovery through September 30, 2009, when Celgene waived its rights with respect to one of the programs during the second quarter of fiscal 2010, at which time, management determined that Celgene is likely to exercise its option to license one of the remaining three programs. Accordingly, beginning October 1, 2009, we began reporting costs associated with the Celgene collaboration as follows: 33.3% to Cost of Revenue, with the remaining 66.7% to Research and Development Expenses for Proprietary Drug Discovery beginning October 1, 2009. See Note 4, “Deferred Revenue,” for further information about the Company’s collaboration with Celgene.
Results of Operations
Collaboration Revenue
Collaboration Revenue consists of revenue for our performance of drug discovery and development activities in collaboration with partners and to a small degree the sale of chemical compounds.
A summary of our collaboration revenue follows (dollars in thousands):
                                                                 
    Three Months Ended     Change 2010 vs.     Nine Months Ended     Change 2010 vs.  
    March 31   2009   March 31,   2009
    2010     2009     $     %     2010     2009     $     %  
                 
 
Collaboration revenue
    $ 5,396       $ 4,399       $ 997       22.7 %     $ 14,874       $ 13,427       $ 1,447       10.8 %
                                 
The increase in Collaboration Revenue of $997 thousand, or 22.7%, in the three months ended March 31, 2010 was from $1.5 million of revenue from our new collaboration with Amgen. Partially offsetting this was a slight decrease to the number of FTEs engaged on our collaboration with Genentech as well as the expiration of our research activities under our collaboration agreement with VentiRx. The increase during the nine months ended March 31, 2010 was also driven by $800 thousand of additional revenue under our collaboration with Genentech, of which $650 thousand recorded in the first quarter of fiscal 2010 was for the finalization of contract rates for services rendered in the prior fiscal year. This increase was offset by fewer scientists engaged on the Genentech program in the third quarter of fiscal 2010 and a $675 thousand decrease in revenue from our collaboration with VentiRx which ended in September 2009.

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x

License and Milestone Revenue
License and Milestone Revenue are combined and consist of up-front license fees and ongoing milestone payments from collaborators.
A summary of our license and milestone revenue follows (dollars in thousands):
                                 
    Three Months Ended     Nine Months Ended  
    March 31,     March 31,  
    2010     2009     2010     2009  
         
 
License revenue
    $ 9,230       $ 1,635       $ 16,286       $ 4,768  
Milestone revenue
    3,750       4       4,750       1,279  
         
Total license and milestone revenue
    $ 12,980       $ 1,639       $ 21,036       $ 6,047  
         
For the three and nine months ended March 31, 2010 and 2009, License Revenue increased $7.6 million and $11.5 million, respectively, over the same periods in the prior year. The increase during the three months ended March 31, 2010 includes $4.9 million in revenue for our new collaboration with Amgen and $2.7 million in additional revenue recognized under the Celgene collaboration due to shortening the estimated performance period from five to two years as of September 30, 2009. (See Note 4, “Deferred Revenue – Celgene Corporation” to the accompanying Condensed Financial Statements.)
For the three and nine months ended March 31, 2010 and 2009, Milestone Revenue increased $3.7 million and $3.5 million, respectively, over the same periods in the prior year. The increase during the three and nine months ended March 31, 2010 includes $3.6 million in milestones received for the advancement of certain research programs under our collaboration with Genentech. Additionally, during the first six months of fiscal 2009 we earned a $1.0 million milestone from VentiRx; we similarly earned a $1.0 million milestone from InterMune during the same period in fiscal 2010.
Cost of Revenue
Cost of Revenue represents costs attributable to discovery and development including preclinical and clinical trials we may conduct for our collaborators and the cost of chemical compounds sold from our inventory. These costs consist mainly of compensation, associated fringe benefits, share-based compensation, preclinical and clinical outsourcing costs and other collaboration-related costs, including supplies, small tools, travel and meals, facilities, depreciation, recruiting and relocation costs and other direct and indirect chemical handling and laboratory support costs.

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A summary of our Cost of Revenue follows (dollars in thousands):
                                                                 
    Three Months Ended                     Nine Months Ended     Change 2010 vs.  
    March 31,   Change 2010 vs. 2009   March 31,   2009
    2010     2009     $     %     2010     2009     $     %  
                 
 
Cost of revenue
    $ 7,946       $ 5,515       $ 2,431       44.1 %     $ 19,103       $ 15,698       $ 3,405       21.7 %
Cost of revenue as a percentage of total revenue
    43.2 %     91.3 %                     53.2 %     80.6 %                
Cost of Revenue increased in absolute dollars and decreased as a percentage of total revenue for the three and nine months ended March 31, 2010 as compared to the same periods in the prior year. The increase in absolute dollars is for preclinical and clinical outsourcing costs for the advancement of certain collaboration programs, including Celgene and our new program with Amgen. These increases were offset by the change in estimate for the Celgene cost allocation from 50% to Cost of Revenue and 50% to Research and Development Expenses for Proprietary Drug Discovery to 33.3% and 67.7%, respectively, as discussed further in Note 4 “Deferred Revenue” to the accompanying Condensed Financial Statements. In addition, there were fewer scientists engaged on our collaboration with Genentech and our collaboration with VentiRx expired in September 2009. The decrease as a percentage of total revenue was because of the increase in license and milestone revenue recognized related to shortening the Celgene recognition period and advancing research programs under our Genentech collaboration, as well as the additional revenue for services in the prior year from Genentech following finalization of contracted rate changes that had no associated incremental costs, as discussed above.
Research and Development Expenses for Proprietary Drug Discovery
Our research and development expenses for proprietary drug discovery include costs associated with our proprietary drug programs for scientific and clinical personnel, supplies, inventory, equipment, small tools, travel and meals, depreciation, consultants, sponsored research, allocated facility costs, costs related to preclinical and clinical trials, and share-based compensation. We manage our proprietary programs based on scientific data and achievement of research plan goals. Our scientists record their time to specific projects when possible; however, many activities simultaneously benefit multiple projects and cannot be readily attributed to a specific project. Accordingly, the accurate assignment of time and costs to a specific project is difficult and may not give a true indication of the actual costs of a particular project. As a result, we do not report costs on a program basis.
The following table shows our research and development expenses by categories of costs for the periods presented (dollars in thousands):
                                                                 
    Three Months Ended                     Nine Months Ended     Change 2010 vs.  
    March 31,   Change 2010 vs. 2009   March 31,   2009
    2010     2009     $     %     2010     2009     $     %  
                 
 
Salaries, benefits and share-based compensation
    $ 8,209       $ 9,989       $ (1,780 )     (17.8 %)     $ 24,088       $ 29,902       $ (5,814 )     (19.4 %)
Outsourced services and consulting
    4,094       4,420       (326 )     (7.4 %)     14,818       18,713       (3,895 )     (20.8 %)
Laboratory supplies
    2,642       1,702       940       55.2 %     8,419       9,338       (919 )     (9.8 %)
Facilities and depreciation
    2,357       2,816       (459 )     (16.3 %)     7,524       8,087       (563 )     (7.0 %)
Other
    390       1,102       (712 )     (64.6 %)     1,148       2,208       (1,060 )     (48.0 %)
                                 
Total research and development for proprietary drug discovery
    $ 17,692       $ 20,029       $ (2,337 )     (11.7 %)     $ 55,997       $ 68,248       $ (12,251 )     (18.0 %)
                                 
Research and Development Expenses for Proprietary Drug Discovery for the three and nine months ended March 31, 2010 decreased from the prior year due to shifting our development efforts towards our

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most advanced programs and reduced resources devoted to early discovery research, which occurred after the second quarter of fiscal 2009. We believe our spending on research and development for our proprietary programs will continue to trend down during fiscal 2010 because our development costs for AMG 151 / ARRY-403 will be shifted to Amgen under our collaboration agreement with Amgen; because our development costs for MEK162 and MEK300 will be shared and deferred with Novartis under our license agreement with them. The increase in costs for laboratory supplies for the three months ended March 31, 2010 as compared to 2009 is due to decreased purchase volumes in the third quarter of fiscal 2009 as a result of cost containment measures and the head count reduction discussed further in Note 10 – Restructuring Charges in our Report on Form 10-K for the year ended June 30, 2009.
General and Administrative Expenses
General and Administrative Expenses consist mainly of compensation and associated fringe benefits not included in Cost of Revenue or Research and Development Expenses for Proprietary Drug Discovery and include other management, business development, accounting, information technology and administration costs, including patent filing and prosecution, recruiting and relocation, consulting and professional services, travel and meals, sales commissions, facilities, depreciation and other office expenses.
A summary of our General and Administrative Expenses follows (dollars in thousands):
                                                                 
    Three Months Ended                     Nine Months Ended     Change 2010 vs.  
    March 31,   Change 2010 vs. 2009   March 31,   2009
    2010     2009     $     %     2010     2009     $     %  
                 
 
General and administrative
    $ 4,264       $ 4,461       $ (197 )     (4.4 %)     $ 12,938       $ 13,435       $ (497 )     (3.7 %)
General and Administrative Expenses remained relatively consistent between the three and nine months ended March 31, 2010 and 2009. In the third quarter of fiscal 2009, we recorded a non-recurring reduction in estimate of compensation expense for employee bonuses related to our staff reduction. Additionally, we incurred $178 thousand and $800 thousand less in patent related expenses in the three and nine month periods, respectively. Decreased patent expenses in the nine month period ended March 31, 2010 was partially offset by higher compensation related expenses.

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Other Income (Expense)
A summary of our Other Income (Expense) follows (dollars in thousands):
                                 
    Three Months Ended     Nine Months Ended  
    March 31,   March 31,  
    2010     2009     2010     2009  
         
 
Impairment of marketable securities
    $ -       $ (3,381 )     $ (217 )     $ (17,742 )
Gain (loss) on sale of marketable securities
    357       -       1,521       -  
Interest income
    164       412       726       1,823  
Interest expense
    (4,152 )     (2,674 )     (11,685 )     (7,289 )
         
Total other income (expense)
    $ (3,631 )     $ (5,643 )     $ (9,655 )     $ (23,208 )
         
The impairment of marketable securities is from the decline in the estimated fair value of our ARS. The investment gains detailed in the table above are the result of the realized gains recorded on the sale of two of our ARS, which were sold in December 2009 and February 2010. See Note 3 “Marketable Securities” in the accompanying Condensed Financial Statements for further information on our ARS.
Interest Income decreased during the three and nine months ended March 31, 2010 as compared to the same periods in fiscal 2009 primarily due to the sale of our two ARS as well as lower effective interest rates and lower average cash and cash equivalent balances in the first nine months of fiscal 2010.
Interest Expense increased in the third quarter and first nine months of fiscal 2010 compared to the same periods in fiscal 2009 due to increased borrowings under the Deerfield credit facilities.
The following table presents the components of Interest Expense for the three and nine months ended March 31, 2010 and 2009 (dollars in thousands):
                                 
    Three Months Ended March 31,   Nine Months Ended March 31,
    2010   2009   2010   2009
 
Deerfield Credit Facility:
                               
2.0% simple interest
    $ -       $ 395       $ 124       $ 1,201  
6.5% compounding interest
    -       1,339       476       4,012  
7.5% simple interest
    2,250       -       6,000       -  
Amortization of transaction fees
    140       795       408       1,612  
Amortization of debt discounts
    1,538       88       4,362       180  
Change in value of the Embedded Derivatives
    7       -       (199 )     -  
 
               
Total interest expense on Deerfield Credit Facility
    3,935       2,617       11,171       7,005  
 
                               
Comerica Loan:
                               
Variable interest
    217       57       514       284  
 
               
Total interest expense on Comerica Loan
    217       57       514       284  
 
               
Total interest expense
    $ 4,152       $ 2,674       $ 11,685       $ 7,289  
 
               
The determination of the estimated fair values of the financial instruments related to the Deerfield credit facilities and the ARS requires significant management judgment with regard to expectations of future cash balances, general and specific economic conditions, forecasts of interest rate behaviors, evaluation of potential acquirers and similar other factors. While we believe that the estimates used in the fair value analysis of the ARS, warrants and the Embedded Derivatives are reasonable, a change in any of the assumptions underlying these estimates would result in different fair value estimates and could result in

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material changes in their fair value. Future changes to the estimated fair values of the Embedded Derivatives will be reflected in our earnings. See Note 3 “Marketable Securities” and Note 5 “Long-term Debt” to the accompanying Condensed Financial Statements for additional information about the ARS and these Embedded Derivatives.
Liquidity and Capital Resources
We have incurred operating losses and have an accumulated deficit primarily as a result of ongoing spending for Research and Development Expenses for Proprietary Drug Discovery. As of March 31, 2010, we had an accumulated deficit of $475.0 million. We had net losses of $15.2 million and $29.6 million for the three months ended March 31, 2010 and 2009, respectively. We had net losses of $61.8 million and $101.1 million for the nine months ended March 31, 2010 and 2009, respectively. We had net losses of $127.8 million, $96.3 million and $55.4 million for the fiscal years ended June 30, 2009, 2008 and 2007, respectively.
We have historically funded our operations through revenue from our collaborations and out-licensing transactions, the issuance of equity securities and through debt provided by our credit facilities. Until we can generate sufficient levels of cash from our operations, which we do not expect to achieve in the foreseeable future, we will continue to utilize our existing cash, cash equivalents and marketable securities that were generated primarily from these sources.
We believe that our cash, cash equivalents and marketable securities, including the $45 million upfront and milestone payment from Novartis International Pharmaceutical Ltd. discussed below and excluding the value of the ARS we hold, will enable us to continue to fund our operations for more than the next 12 months. We have recently signed and are currently in active licensing discussions with a number of potential partners on select programs. In December 2009, we received a $60 million up front payment from Amgen Inc. under a Collaboration and License Agreement with Amgen for our small-molecule glucokinase activator, AMG 151 / ARRY-403. In April 2010, we signed a License Agreement with Novartis International Pharmaceutical Ltd. under which we will receive $45 million in an upfront and milestone payment in the fourth quarter of fiscal 2010, as discussed further in Note 10 “Subsequent Event” to the accompanying Condensed Financial Statements. Our current operating plan contemplates the receipt of significant additional upfront payments from new collaboration or licensing deals and milestone payments from existing collaborations in the next 12 months. There can be no guarantee, however, that we will be successful in entering into new collaboration or licensing transactions that include such payments or that the milestones will be achieved under existing collaborations resulting in the receipt of milestone payments when anticipated.
If we are unable to obtain additional funding from these or other sources to the extent or when needed, it may be necessary to significantly reduce our current rate of spending through further reductions in staff and delaying, scaling back or stopping certain research and development programs. Insufficient funds may also require us to relinquish greater rights to product candidates at an earlier stage of development or on less favorable terms to us or our stockholders than we would otherwise choose in order to obtain up-front license fees needed to fund our operations.
We cannot assure that we will be successful in obtaining new or in retaining existing out-license or collaboration agreements, in securing agreements for the co-development of our proprietary drug candidates, or in receiving milestone and/or royalty payments under those agreements when anticipated or at all, that our existing cash, cash equivalents and marketable securities resources will be adequate or that additional financing will be available when needed or that, if available, this financing will be obtained on terms favorable to us or our stockholders. If we raise additional funds by issuing equity or convertible debt securities, substantial dilution to existing stockholders may result.

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Our ability to realize milestone or royalty payments under existing collaboration agreements, and to enter into new partnering arrangements that generate additional revenue through up-front fees and milestone or royalty payments, is subject to a number of risks, many of which are beyond our control and include the following: the drug development process is risky and highly uncertain, and we may not be successful in generating proof-of-concept data to create partnering opportunities, and even if we are, we or our collaborators may not be successful in commercializing drug candidates we create; our collaborators have substantial control and discretion over the timing and continued development and marketing of drug candidates we create and, therefore, we may not receive milestone, royalty or other payments when anticipated or at all; the drug candidates we develop may not obtain regulatory approval; and, if regulatory approval is received, drugs we develop will remain subject to regulation or may not gain market acceptance, which could delay or prevent us from generating milestone, royalty revenue or product revenue from the commercialization of these drugs.
Our assessment of our future need for funding is a forward-looking statement that is based on assumptions that may prove to be wrong and that involve substantial risks and uncertainties. Our actual future capital requirements could vary as a result of a number of factors, including:
   
Our ability to enter into agreements to out-license, co-develop or commercialize our proprietary drug candidates, and the timing of payments under those agreements throughout each candidate’s development stage;
 
   
The number and scope of our research and development programs;
 
   
The progress and success of our preclinical and clinical development activities;
 
   
The progress of the development efforts of our collaborators;
 
   
Our ability to maintain current collaboration agreements;
 
   
The costs involved in enforcing patent claims and other intellectual property rights;
 
   
The costs and timing of regulatory approvals;
 
   
The expenses associated with unforeseen litigation, regulatory changes, competition and technological developments, general economic and market conditions and the extent to which we acquire or invest in other businesses, products and technologies.
Cash, Cash Equivalents and Marketable Securities
Cash equivalents are short-term, highly liquid financial instruments that are readily convertible to cash and have maturities of 90 days or less from the date of purchase.
Marketable securities classified as short-term consist primarily of various financial instruments such as commercial paper, U.S. government agency obligations and corporate notes and bonds with high credit quality with maturities of greater than 90 days when purchased. Marketable securities classified as long-term consist of our investments in ARS. See Note 3 “Marketable Securities” in the accompanying Condensed Financial Statements for more information regarding our ARS. Our ability to sell the ARS is substantially limited due to auctions that continue to be suspended for these securities in the related markets. In the event we need to access these funds and liquidate the ARS prior to the time auctions of these investments are successful or the date on which the original issuers retire these securities, we may be required to sell them in a distressed sale in a secondary market, most likely for a lower value than their current fair value. In the second and third quarters of fiscal 2010, we sold ARS with a par value of $4.0 million and $2.6 million, respectively, for $2.8 million and for $715 thousand, respectively.
Following is a summary of our cash, cash equivalents and marketable securities (dollars in thousands):

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    March 31,     June 30,              
    2010     2009     $ Change     % Change  
         
 
                               
Cash and cash equivalents
    $ 82,560       $ 33,202       $ 49,358       148.7 %
Marketable securities - short-term
    19       7,296       (7,277 )     (99.7 %)
Marketable securities - long-term
    17,757       16,990       767       4.5 %
                 
Total
    $ 100,336       $ 57,488       $ 42,848       74.5 %
                 
Cash Flow Activities
Following is a summary of our cash flows (dollars in thousands):
                                 
    Nine Months Ended March 31,   Change 2009 vs. 2008
    2010     2009     $     %  
         
 
                               
Cash flows provided by (used in):
                               
Operating activities
    $ (3,734 )     $ (74,133 )     $ 70,399       (95.0 %)
Investing activities
    9,814       28,571       (18,757 )     (65.7 %)
Financing activities
    43,278       40,675       2,603       6.4 %
                 
Total
    $ 49,358       $ (4,887 )     $ 54,245       *  
                 
*  
Percentage calculated was not meaningful
First Nine Months of Fiscal 2010 - Net cash used in operating activities for the first half of fiscal 2010 was $3.7 million, compared to $74.1 million for fiscal 2009. The difference is primarily attributable to the receipt of $60 million from Amgen Inc. in December 2009 under our License and Collaboration Agreement with them, and to a lesser extent, reduced spending on advancing our own proprietary programs, which decreased net loss, as well as the issuance of stock as payment of 2009 employee bonuses during fiscal 2010 compared to cash bonus distribution during the prior year.
Net cash provided by investing activities was $9.8 million and $28.6 million in the first nine months of fiscal 2010 and 2009, respectively. During the first nine months of fiscal 2010, we invested $2.0 million less in property and equipment than we did in the same period of the prior year related to our plan to reduce overall spending. There were no purchases of marketable securities as well as fewer proceeds from sales compared to the same period in the prior year as a result of our initiative to invest our monies in more liquid, U.S. treasury backed securities.
Net cash provided by financing activities was $43.3 million and $40.7 million for the first nine months of fiscal 2010 and 2009, respectively. This increase was primarily due to the net proceeds of $3.2 million from sales of shares of our common stock under our Equity Distribution Agreement with Piper Jaffray & Co. during the first nine months of fiscal 2010.

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Obligations and Commitments
The following table shows our contractual obligations and commitments as of March 31, 2010 (dollars in thousands):
                                         
    Less Than     1 to 3     4 to 5              
    1 Year     Years     Years      Over 5 Years     Total  
     
 
                                       
Debt obligations (1)
    $ -           $ -           $ 141,762       $ -           $ 141,762  
Interest on debt obligations (3) (4)
    9,488       18,976       10,030       -           38,494  
Operating lease commitments (2)
    7,868       15,989       16,445       10,687       50,989  
Purchase obligations (2)
    15,805       1,497       6       1       17,309  
     
Total
    $ 33,161       $ 36,462       $ 168,243       $ 10,688       $ 248,554  
     
(1)  
Reflected in the accompanying Condensed Balance Sheets.
 
(2)  
These obligations are not reflected in the accompanying Condensed Balance Sheets.
 
(3)  
Interest on the variable debt obligations under the Loan and Security Agreement with Comerica Bank is calculated at 3.25%, the interest rate in effect as of March 31, 2010.
 
(4)  
Interest on the variable debt obligation under the credit facilities with Deerfield is calculated at 7.5%, the interest rate in effect as of March 31, 2010.
We are obligated under non-cancelable operating leases for all of our facilities and under certain equipment leases. Original lease terms for our facilities in effect as of March 31, 2010 were five to 10 years and generally require us to pay the real estate taxes, insurance and other operating costs. Equipment lease terms generally range from three to five years.
Purchase obligations totaling $9.9 million are for outsourced services for clinical trials and other research and development costs. Additional purchase obligations of $4.2 million were primarily for software to support the advancement of clinical trials, lab supplies and ongoing equipment and facilities maintenance. The remaining $3.2 million is for all other purchase commitments.
ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
Market risk represents the risk of loss that may impact our financial position, results of operations or cash flows due to adverse changes in financial and commodity market prices, such as the liquidity of ARS we hold and fluctuations in interest rates. All of our collaboration agreements and nearly all purchase orders are denominated in U.S. dollars. As a result, historically and as of March 31, 2010, we have had little exposure to market risk from changes in foreign currency or exchange rates.
Our investment portfolio, without regard to our ARS, is comprised primarily of readily marketable, high-quality securities diversified and structured to minimize market risks. We target our average portfolio maturity at one year or less. Our exposure to market risk for changes in interest rates relates primarily to our investments in marketable securities. Marketable securities held in our investment portfolio are subject to changes in market value in response to changes in interest rates and liquidity. As of March 31, 2010, $17.0 million of our investment portfolio was invested in ARS that are not marketable as discussed below. In addition, a significant change in market interest rates could have a material impact on interest income earned from our investment portfolio. A theoretical 100 basis point change in interest rates and security prices would impact our annual net income (loss) positively or negatively by $1.0 million based on the current balance of $100.3 million of investments classified as cash and cash equivalents, and short-term and long-term marketable securities available for sale.
Our long-term marketable securities investment portfolio includes ARS. During the fiscal year ended June 30, 2008 and subsequent thereto, auctions for all of our ARS were unsuccessful. As of March 31, 2010,

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we held five securities with a par value of $26.3 million and a fair value of $17.0 million. As of June 30, 2009, we held seven securities with a par value of $32.9 million and a fair value of $16.5 million. We sold one of the ARS in the second quarter of fiscal 2010 with a par value of $4.0 million for $2.8 million and realized a gain of $1.2 million, with $394 thousand reclassified from Accumulated Other Comprehensive Income. We sold another ARS in the third quarter of fiscal 2010 with a par value of $2.6 million for $715 thousand and realized a gain of $357 thousand, with $524 thousand reclassified to earnings from Accumulated Other Comprehensive Income.
Due to these unsuccessful auctions and continuing uncertainty and volatility in the credit markets, the fair value of our ARS has fluctuated and we have therefore recorded fair value adjustments to our ARS. We recorded an unrealized gain of $711 thousand for the three months ended March 31, 2010. We recorded an unrealized gain of $2.7 million and a realized loss of $217 thousand for the nine months ended March 31, 2010, respectively. We recorded a realized loss of $3.4 million and of $17.7 million for the three and nine months ended March 31, 2009, respectively. The unrealized gains are included in Accumulated Other Comprehensive Income in the accompanying Condensed Balance Sheets. The realized losses are included in Impairment of Marketable Securities in the accompanying Statements of Income and Comprehensive Loss because they are considered other than temporary. We have recorded cumulative loss adjustments of $11.9 million to the ARS as of March 31, 2010. Due to the volatility of the underlying credit markets, the fair value of the ARS may continue to fluctuate and we may experience additional impairments. In the event we need to access any of our ARS prior to the time auctions of these investments are successful or the original issuers retire these securities, we will be required to sell them in a distressed sale in a secondary market, most likely for a significantly lower amount than their current fair value.
As of March 31, 2010, we had $141.8 million of debt outstanding, exclusive of the debt discount of $30.5 million. The Refinance Term Loan under our senior secured credit facility with Comerica Bank of $15.0 million is variable rate debt. Assuming constant debt levels, a theoretical change of 100 basis points on our current interest rate of 3.25% on the Comerica debt as of March 31, 2010 would result in a change in our annual interest expense of $150 thousand. The interest rate on our long-term debt under the credit facilities with Deerfield is variable based on our total cash, cash equivalents and marketable securities balances. Assuming constant debt levels, a theoretical change of 100 basis points on our current rate of interest of 7.5% on the Deerfield credit facilities as of March 31, 2010 would result in a change in our annual interest expense of $1.2 million.
Historically, and as of March 31, 2010, we have not used foreign currency derivative instruments or engaged in hedging activities.
ITEM 4. CONTROLS AND PROCEDURES
Evaluation of Disclosure Controls and Procedures
Under the supervision and with the participation of our Chief Executive Officer, Chief Financial Officer and other senior management personnel, we evaluated the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the period covered by this Quarterly Report on Form 10-Q (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934). Based on this evaluation, our Chief Executive Officer and Chief Financial Officer have concluded that our disclosure controls and procedures as of March 31, 2010 were effective to provide a reasonable level of assurance that the information we are required to disclose in reports that we submit or file under the Securities Act of 1934 (i) is recorded, processed, summarized and reported within the time periods specified in the SEC rules and forms; and (ii) is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosure. Our disclosure controls and procedures are designed to provide reasonable assurance that such information is accumulated and communicated to management. Our disclosure controls and procedures include components of our internal control over financial reporting.

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Management’s assessment of the effectiveness of our disclosure controls and procedures is expressed at a reasonable level of assurance because an internal control system, no matter how well designed and operated, can provide only reasonable, but not absolute, assurance that the internal control system’s objectives will be met.
Changes in Internal Control over Financial Reporting
There were no changes in our internal control over financial reporting during the quarter ended March 31, 2010 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION
ITEM 1. LEGAL PROCEEDINGS
None
ITEM 1A. RISK FACTORS
Investing in our common stock is subject to a number of risks and uncertainties. We have updated the following risk factors to reflect changes during the quarter ended March 31, 2010 we believe to be material to the risk factors set forth in our Annual Report on Form 10-K for the fiscal year ended June 30, 2009 filed with the Securities and Exchange Commission. The risks and uncertainties described below are not the only ones that we face and are more fully described in our Annual Report on Form 10-K and in other reports we file with the Securities and Exchange Commission. Additional risks and uncertainties not presently known to us or that we currently believe are immaterial also may negatively impact our business.
Risks Related to Our Business
We expect to continue to incur significant research and development expenses, which may make it difficult for us to attain profitability.
We have expended substantial funds to discover and develop our drug candidates, and additional substantial funds will be required for further development, including pre-clinical testing and clinical trials of any product candidates, and to manufacture and market any products that are approved for commercial sale. Because the successful development of our products is uncertain, we are unable to precisely estimate the actual funds we will require to develop and potentially commercialize them.
If we are unable to generate enough revenue, or to secure additional funding and/or reduce our current rate of research and development spending, we may not be able to fund our current operations. This may result in an inability to maintain a level of liquidity necessary to continue operating our business and the loss of all or part of the investment of our stockholders in our common stock. In addition, under our credit facility with Deerfield Private Design Fund, L.P. and Deerfield Private Design International Fund, L.P. (who we refer to collectively as Deerfield) and our loan agreement with Comerica Bank, if we are unable to maintain certain levels of cash and marketable securities, the lenders may be able to accelerate our obligations under our agreements with them. There is no guaranty that we will secure additional financing needed to fund our current operations and maintain lender-required levels of cash.
We have a history of operating losses and may not achieve or sustain profitability.
We have incurred significant operating and net losses and negative cash flows from operations since our inception. As of March 31, 2010, we had an accumulated deficit of $475.0 million. We had net losses of $15.2 million and $29.6 million for the three months ended March 31, 2010 and 2009, respectively. We had net losses of $61.8 million and $101.1 million for the nine months ended March 31, 2010 and 2009, respectively. We had net losses of $127.8 million, $96.3 million and $55.4 million, for the fiscal years ended June 30, 2009, 2008 and 2007, respectively. We expect to incur additional losses and negative cash flows in the future, and these losses may continue or increase in part due to anticipated levels of expenses for research and development, particularly clinical development, and expansion of our clinical and scientific capabilities. At the same time, we expect that revenue from the sales of our research tools and services will continue to decline as a percentage of total revenue as we devote more resources to drug discovery and our proprietary drug programs. As a result, we may not be able to achieve or maintain profitability.

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Moreover, if we do achieve profitability, the level of any profitability cannot be predicted and may vary significantly. Much of our current revenue is non-recurring in nature and unpredictable as to timing and amount. While several of our out-licensing and collaboration agreements provide for royalties on product sales, given that none of our drug candidates have been approved for commercial sale, that our drug candidates are at early stages of development and that drug development entails a high degree of risk of failure, we do not expect to receive any royalty revenue for several years, if at all. For the same reasons, we may never realize much of the milestone revenue provided for in our out-license and collaboration agreements. Similarly, drugs we select to commercialize ourselves or partner for later-stage co-development and commercialization may not generate revenue for several years, or at all.
Because we rely on a small number of collaborators for a significant portion of our revenue, if one or more of our major collaborators terminates or reduces the scope of its agreement with us, our revenue may significantly decrease.
A relatively small number of collaborators account for a significant portion of our revenue. Genentech, Celgene and Amgen accounted for 48.0%, 27.5% and 20.3%, respectively, of our total revenue for the first nine months of fiscal 2010; and Genentech and Celgene accounted for 66.4% and 22.0%, respectively, of our total revenue in the same period of fiscal 2009. We expect that revenue from a limited number of collaborators, including Celgene, Genentech, Amgen and Novartis, will account for a large portion of our revenue in future quarters. In general, our collaborators may terminate their contracts with us upon 60 to 180 days’ notice for a number of reasons. In addition, some of our major collaborators can determine the amount of products delivered and research or development performed under these agreements. As a result, if any one of our major collaborators cancels, declines to renew or reduces the scope of its contract with us, our revenue may significantly decrease.
Our investments in ARS are not currently liquid and our inability to access these funds may adversely affect our liquidity, capital resources and results of operations. We may be required to further adjust the carrying value of our investment through an impairment charge.
A portion of our investment portfolio is invested in ARS. During the fiscal year ended June 30, 2008, auctions for all of the ARS, amounting to seven securities, were unsuccessful. During the first quarter of fiscal 2009, auctions were suspended when Lehman Brothers filed for bankruptcy. As a result, these securities are no longer readily convertible to cash. In the event we need to access these funds, we will not be able to sell these securities for cash until a secondary market develops for these securities. We can make no assurances that this will occur prior to the time that we may need to access these investments or, if they do, what value we will realize on our ARS. In addition, as currently there is not an active market for these securities, we estimated the fair value of these securities using a discounted cash flow model based on assumptions that management believes to be reasonable but that may prove to be inaccurate. Due to the unsuccessful auctions and continuing uncertainty and volatility in the credit markets, the fair value of our ARS has fluctuated and we have therefore recorded fair value adjustments to our ARS. Based on this analysis, we recorded an unrealized gain of $1.2 million for the three months ended March 31, 2010. We recorded an unrealized gain of $3.6 million and a realized loss of $217 thousand for the nine months ended March 31, 2010, respectively. We recorded a realized loss of $3.4 million and of $17.7 million for the three and nine months ended March 31, 2009, respectively. If the market makers in these securities are unable to successfully conduct future auctions or the issuer’s credit ratings deteriorate, or if our estimates of fair value later prove to be inaccurate, we may be required to further adjust the carrying value of some or all of these investments. In addition, if we are required to liquidate these ARS prior to the time auctions for them are successful or the issuer redeems them, we may be required to sell them at a significant discount to their par value.

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We may not be successful in entering into additional out-license agreements on favorable terms, which may adversely affect our liquidity or require us to change our spending priorities on our proprietary programs.
We are committing significant resources to create our own proprietary drug candidates and to build a commercial-stage biopharmaceutical company. We have built our proprietary pipeline of research and development programs on spending of $403.2 million from our inception through March 31, 2010. We continue to commit significant resources to create our own proprietary drug candidates and to build a commercial-stage biopharmaceutical company. In the first nine months of fiscal 2010 and 2009, our spending on research and development for proprietary drug discovery was $56.0 million and $68.2 million, respectively. In fiscal 2009, we spent $89.6 million in research and development for proprietary drug discovery expenses, as compared to $90.3 million and $57.5 million for fiscal years 2008 and 2007, respectively. Our proprietary drug discovery programs are in their early stage of development and are unproven. Our ability to continue to fund our planned spending on our proprietary drug programs and in building our commercial capabilities depends to a large degree on up-front fees, milestone payments and other revenue we receive as a result of our partnered programs. To date, we have entered into six out-licensing agreements for the development and commercialization of our drug candidates, and we plan to accelerate initiatives during fiscal 2010 to partner select clinical candidates to obtain additional capital. We may not be successful, however in entering into additional out-licensing agreements with favorable terms, including up-front, milestone, royalty and/or license payments and the retention of certain valuable commercialization or co-promote rights, as a result of factors, many of which are outside of our control. These factors include:
   
Our ability to create valuable proprietary drugs targeting large market opportunities;
 
   
Research and spending priorities of potential licensing partners;
 
   
Willingness of and the resources available to pharmaceutical and biotechnology companies to in-license drug candidates to fill their clinical pipelines;
 
   
The success or failure, and timing, or pre-clinical and clinical trials on our proprietary programs we intend to out-license; or
 
   
Our ability or inability to generate proof-of-concept data and to agree with a potential partner on the value of proprietary drug candidates we are seeking to out-license, or on the related terms.
If we are unable to enter into out-licensing agreements and realize milestone, license and/or upfront fees when anticipated, it may adversely affect our liquidity and we may be forced to curtail or delay development of all or some of our proprietary programs, which in turn may harm our business and the value of our stock. In addition, insufficient funds may require us to relinquish greater rights to product candidates at an earlier stage of development or on less favorable terms to us or our stockholders than we would otherwise choose in order to obtain funding for further development and/or up-front license fees needed to fund our operations.
If we need but are unable to obtain additional funding to support our operations, we could be unable to successfully execute our operating plan or be forced to reduce our operations.
We have historically funded our operations through revenue from our collaborations and out-license transactions, the issuance of equity securities and debt financing. We used $63.7 million from our operating activities in the first nine months of fiscal 2010 exclusive of the $60 million up-front license fee from Amgen Inc., and $92.9 million, $45.7 million and $44.5 million in our operating activities in fiscal 2009, 2008 and 2007, respectively. In addition, a portion of our cash flow is dedicated to the payment of interest under our existing senior secured credit facility with Comerica Bank, and to the payment of principal and interest on our credit facilities with Deerfield. In addition, the Senior Credit Facility and the Deerfield Credit Facilities become due and payable in 2013 and 2014, respectively. Our debt

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obligations could therefore render us more vulnerable to competitive pressures and economic downturns and impose some restrictions on our operations.
Our current operating plan and assumptions could change as a result of many factors, and we could require additional funding sooner than anticipated. In addition, we are currently unable to liquidate ARS we hold with an aggregate cost of $26.3 million and a fair value of $17.0 million. If we are unable to meet our capital requirements from cash generated by our future operating activities and are unable to obtain additional funds when needed, we may be required to curtail operations significantly or to obtain funds through other arrangements on unattractive terms, which could prevent us from successfully executing our operating plan. If we raise additional capital through the sale of equity or convertible debt securities, the issuance of those securities would result in dilution to our stockholders.
Recent disruptions in the financial markets could affect our ability to obtain financing for development of our proprietary drug programs and other purposes on reasonable terms and have other adverse effects on us and the market price of our common stock.
The United States stock and credit markets have recently experienced significant price volatility, dislocations and liquidity disruptions, which have caused market prices of many stocks to fluctuate substantially and the spreads on prospective debt financings to widen considerably. These circumstances have materially impacted liquidity in the financial markets, making terms for certain financings less attractive, and in some cases have resulted in the unavailability of financing. For example, during the first quarter of fiscal 2009, auctions for ARS that we hold were suspended when Lehman Brothers filed for bankruptcy and we are currently unable to liquidate these securities. Continued uncertainty in the stock and credit markets may negatively impact our ability to access additional financing for our research and development activities and other purposes on reasonable terms, which may cause us to curtail or delay our discovery and development efforts and harm our business. In January 2009, we announced plans designed to conserve our existing capital and to allow us to obtain additional capital outside the financial markets by accelerating partnering opportunities and focusing resources on advancing the development of our most advanced clinical programs. As part of these efforts we also reduced our workforce by 40 employees. A prolonged downturn in the financial markets, however, may cause us to seek alternative sources of potentially less attractive financing, and may require us to make further adjustments to our business plan. These events also may make it more difficult or costly for us to raise capital through the issuance of equity or debt. The disruptions in the financial markets may have a material adverse effect on the market value of our common stock and other adverse effects on us and our business.
Because our stock price may be volatile, our stock price could experience substantial declines.
The market price of our common stock has historically experienced and may continue to experience volatility. The high and low closing bids for our common stock were $2.83 and $2.24, respectively, during the third quarter of fiscal 2010; $2.81 and $1.72, respectively, during the second quarter of fiscal 2010; $4.45 and $2.38, respectively during the first quarter of fiscal 2010; $8.79 and $2.51, respectively, during fiscal 2009; $12.91 and $4.66, respectively, in fiscal 2008; and $14.40 and $7.55, respectively, in fiscal 2007. Our quarterly operating results, the success or failure of our internal drug discovery efforts, decisions to delay, modify or cease one or more of our development programs, uncertainties about our ability to continue to operate as a going concern, changes in general conditions in the economy or the financial markets and other developments affecting our collaborators, our competitors or us could cause the market price of our common stock to fluctuate substantially. This volatility coupled with market declines in our industry over the past several years have affected the market prices of securities issued by many companies, often for reasons unrelated to their operating performance, and may adversely affect the price of our common stock. In the past, securities class action litigation has often been instituted following periods of volatility in the market price of a company’s securities. A securities class action suit against us could result in potential liabilities, substantial costs and the diversion of management’s attention and resources, regardless of whether we win or lose.

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We may not be able to recruit and retain the experienced scientists and management we need to compete in the drug research and development industry.
We had 338 employees as of March 31, 2010, and our future success depends upon our ability to attract, retain and motivate highly skilled scientists and management. Our ability to achieve our business strategies, including progressing drug candidates through later stage development or commercialization, attracting new collaborators and retaining, renewing and expanding existing collaborations, depends on our ability to hire and retain high caliber scientists and other qualified experts, particularly in clinical development and commercialization. We compete with pharmaceutical and biotechnology companies, contract research companies and academic and research institutions to recruit personnel and face significant competition for qualified personnel, particularly clinical development personnel. We may incur greater costs than anticipated, or may not be successful, in attracting new scientists or management or in retaining or motivating our existing personnel.
Our future success also depends on the personal efforts and abilities of the principal members of our senior management and scientific staff to provide strategic direction, manage our operations and maintain a cohesive and stable environment. In particular, we rely on the services of Robert E. Conway, our Chief Executive Officer; Dr. Kevin Koch, our President and Chief Scientific Officer; Dr. David L. Snitman, our Chief Operating Officer and Vice President, Business Development; R. Michael Carruthers, our Chief Financial Officer; and John R. Moore, our Vice President and General Counsel. We have employment agreements with all of the above personnel that are terminable upon 30 days’ prior notice.
ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS
None
ITEM 3. DEFAULTS UPON SENIOR SECURITIES
None
ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
None
ITEM 5. OTHER INFORMATION
None
ITEM 6. EXHIBITS
     
Exhibit Number   Description of Exhibit
 
   
31.1
  Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended.
31.2
  Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended.
32.1
  Certifications of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on this 3rd day of May 2010.
         
    ARRAY BIOPHARMA INC.
 
 
  By:   /s/ Robert E. Conway    
    Robert E. Conway   
    Chief Executive Officer   
 
     
  By:   /s/ R. Michael Carruthers    
    R. Michael Carruthers   
    Chief Financial Officer
(Principal Financial and
Accounting Officer)
 
 
 

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