Prospectus  Supplement  No.  1
                                                               Filed Pursuant to
                                                        Rule 424 (b) (3) and (c)
                                                              File No. 333-62094

                                 EXELIXIS, INC.
                                2,270,522 SHARES
                                  COMMON STOCK

                ------------------------------------------------
     This prospectus supplement supplements the prospectus, dated June 12, 2001,
of  Exelixis,  Inc.  relating  to  the  public  offering,  which  is  not  being
underwritten,  and sale of up to 2,270,522 shares of our common stock by selling
stockholders  of  Exelixis  (or  by  donees,  pledgees,  transferees  and  other
successors  in  interest that receive such shares as a gift, pledge, partnership
distribution  or  other non-sale transfer) who recived such shares in connection
with  our  acquisition  of  Artemis  Pharmaceuticals  GmbH.  This  prospectus
supplement  should  be  read  in  conjunction  with  the  prospectus,  and  this
prospectus supplement is qualified by reference to the prospectus, except to the
extent  that  the  information provided by this prospectus supplement supersedes
the  information  contained  in  the  prospectus.

SEE  "RISK  FACTORS" BEGINNING ON PAGE 4 OF THE PROSPECTUS TO READ ABOUT FACTORS
YOU  SHOULD  CONSIDER  BEFORE  BUYING  OUR  COMMON  STOCK.


                ------------------------------------------------

     The  shares offered or sold under this prospectus have not been approved by
the  Securities  and  Exchange Commission or any state securities commission nor
have  any  of these organizations determined that this prospectus is accurate or
complete.  Any  representation  to  the  contrary  is  a  criminal  offense.


                ------------------------------------------------








            The date of this prospectus supplement is June 26, 2002.




     The  table  and  related  notes appearing in the prospectus, dated June 12,
2001,  under  the  heading "Selling Stockholders" is superseded by the following
table  and  related  notes  as  of  June  26,  2002:





                                                      Selling Stockholders

                                                                Shares  Beneficially                      Shares Beneficially
                                                                 Owned Prior to the       Number of         Owned After the
                                                                      Offering           Shares Being          Offering (1)
                                                                ---------------------                     --------------------
Name                                                              Number     Percent        Offered        Number    Percent
--------------------------------------------------------------  ---------  ----------   -----------------  --------- ----------
                                                                                                      
3i Group Investments Limited Partnership . . . . . . . . . . .    387,706           *            387,706          0          *
Advent Partners Limited Partnership(2) . . . . . . . . . . . .     68,078           *              4,064     64,014          *
Advent Performance Materials Limited
Partnership(2) . . . . . . . . . . . . . . . . . . . . . . . .    296,592           *              9,347    287,245          *
Adwest Limited Partnership(2). . . . . . . . . . . . . . . . .    169,831           *              5,690    164,141          *
Rovent II Limited Partnership(2) . . . . . . . . . . . . . . .  1,185,153         2.4%            36,170  1,148,983        2.3%
Atlas Venture Europe Fund B.V.(3). . . . . . . . . . . . . . .  1,263,450         2.6             26,010  1,237,440        2.5
Atlas Venture Fund II, L.P.(3) . . . . . . . . . . . . . . . .  2,641,418         5.4            160,122  2,481,296        5.1
Atlas Venture Germany B.V.(3). . . . . . . . . . . . . . . . .     54,051           *             54,051          0          *
Guido Arens. . . . . . . . . . . . . . . . . . . . . . . . . .      1,741           *              1,741          0          *
Martina Beck . . . . . . . . . . . . . . . . . . . . . . . . .        120           *                120          0          *
Petra Beeckmann. . . . . . . . . . . . . . . . . . . . . . . .      1,703           *              1,703          0          *
Marion Bernzen . . . . . . . . . . . . . . . . . . . . . . . .        527           *                527          0          *
Gerd Beyer . . . . . . . . . . . . . . . . . . . . . . . . . .      2,044           *              2,044          0          *
Biotechvest Limited Partnership. . . . . . . . . . . . . . . .      2,032           *              2,032          0          *
Commerz Beteiligungsgesellschaft GmbH. . . . . . . . . . . . .     38,608           *             38,608          0          *
Maria da Silva . . . . . . . . . . . . . . . . . . . . . . . .         96           *                 96          0          *
Alf Domeyer. . . . . . . . . . . . . . . . . . . . . . . . . .      1,703           *              1,703          0          *
Peter Erken. . . . . . . . . . . . . . . . . . . . . . . . . .         45           *                 45          0          *
Nicole Faust . . . . . . . . . . . . . . . . . . . . . . . . .      5,272           *              5,272          0          *
Susanne Felder . . . . . . . . . . . . . . . . . . . . . . . .      2,413           *              2,413          0          *
Manuela Flad . . . . . . . . . . . . . . . . . . . . . . . . .        193           *                193          0          *
Berthold Gierke. . . . . . . . . . . . . . . . . . . . . . . .        460           *                460          0          *
Nicole Glesmann. . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Global Life Science Holding V GmbH . . . . . . . . . . . . . .    100,787           *            100,787          0          *
Monique Goerl. . . . . . . . . . . . . . . . . . . . . . . . .        209           *                209          0          *
Iris Gorcke. . . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Sandra Graf. . . . . . . . . . . . . . . . . . . . . . . . . .        173           *                173          0          *
Ursula Hagner. . . . . . . . . . . . . . . . . . . . . . . . .        133           *                133          0          *
Monika Hahn-Wansel . . . . . . . . . . . . . . . . . . . . . .      1,741           *              1,741          0          *
Cornelia Heimann . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Thomas Hennek. . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Elisabeth Hennen . . . . . . . . . . . . . . . . . . . . . . .        240           *                240          0          *
Biomedicine L.P.(4). . . . . . . . . . . . . . . . . . . . . .    399,085           *            399,085          0          *
Rudi Jaenisch. . . . . . . . . . . . . . . . . . . . . . . . .      3,548           *              3,548          0          *
Michelle Johnson . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Christian Kaps . . . . . . . . . . . . . . . . . . . . . . . .      1,135           *              1,135          0          *
Gunter Kauselmann. . . . . . . . . . . . . . . . . . . . . . .      3,990           *              3,990          0          *
Heinrich Kehlbeck. . . . . . . . . . . . . . . . . . . . . . .      3,066           *              3,066          0          *
Heidrun Kern . . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Mike Kierdorf. . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Anja Kirchner. . . . . . . . . . . . . . . . . . . . . . . . .        201           *                201          0          *
Thomas Koblizek Dr . . . . . . . . . . . . . . . . . . . . . .      1,703           *              1,703          0          *
Dagmar Kluth . . . . . . . . . . . . . . . . . . . . . . . . .      2,163           *              2,163          0          *
Nicole Krafzik . . . . . . . . . . . . . . . . . . . . . . . .        870           *                870          0          *
Barbara Kraus. . . . . . . . . . . . . . . . . . . . . . . . .      3,390           *              3,390          0          *
Ralf Kuhn. . . . . . . . . . . . . . . . . . . . . . . . . . .     18,656           *             18,656          0          *
Birgit Kuter-Luks. . . . . . . . . . . . . . . . . . . . . . .        475           *                475          0          *
Janice Labedzki. . . . . . . . . . . . . . . . . . . . . . . .        144           *                144          0          *
Ulrike Langheinrich. . . . . . . . . . . . . . . . . . . . . .      5,272           *              5,272          0          *
Carsten Loeschke . . . . . . . . . . . . . . . . . . . . . . .         45           *                 45          0          *
Sabine Maurer. . . . . . . . . . . . . . . . . . . . . . . . .         66           *                 66          0          *
Dagmar Megerle . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
MILOS Vermogensverwaltungs GmbH. . . . . . . . . . . . . . . .     93,066           *             93,066          0          *
Heiderose Neu. . . . . . . . . . . . . . . . . . . . . . . . .        235           *                235          0          *
Renate Nordin. . . . . . . . . . . . . . . . . . . . . . . . .        120           *                120          0          *
Christiane Nusslein-Volhand. . . . . . . . . . . . . . . . . .    131,674           *            131,674          0          *
Jorg Odenthal. . . . . . . . . . . . . . . . . . . . . . . . .     11,194           *             11,194          0          *
Oxford Bioscience Partners (Adjunct) II Limited Partnership(5)     12,599           *             12,599          0          *
Oxford Bioscience Partners (Bermuda) II Limited Partnership(5)     33,325           *             33,325          0          *
Oxford Bioscience Partners (GS-Adjunct) II
Limited Partnership(5) . . . . . . . . . . . . . . . . . . . .     44,297           *             44,297          0          *
Oxford Bioscience Partners II Limited
Partnership(5) . . . . . . . . . . . . . . . . . . . . . . . .     45,517           *             45,517          0          *
Niketan Pandit . . . . . . . . . . . . . . . . . . . . . . . .        227           *                227          0          *
Stelios Papadopoulos(6). . . . . . . . . . . . . . . . . . . .    482,277           *              4,064    478,213          *
Margot Paul. . . . . . . . . . . . . . . . . . . . . . . . . .        240           *                240          0          *
Marion Pezzuti . . . . . . . . . . . . . . . . . . . . . . . .        120           *                120          0          *
Max-Planck-Gesellschaft. . . . . . . . . . . . . . . . . . . .     50,800           *             50,800          0          *
Yvonne Postma. . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Christiane Priebnitz . . . . . . . . . . . . . . . . . . . . .        416           *                416          0          *
Klaus Rajewsky . . . . . . . . . . . . . . . . . . . . . . . .    131,674           *            131,674          0          *
Karlheinz Rein . . . . . . . . . . . . . . . . . . . . . . . .      1,703           *              1,703          0          *
Anja Rode. . . . . . . . . . . . . . . . . . . . . . . . . . .        713           *                713          0          *
Paul Rounding. . . . . . . . . . . . . . . . . . . . . . . . .     10,545           *             10,545          0          *
Andrea Sabiwalsky. . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
Caroline Samuel. . . . . . . . . . . . . . . . . . . . . . . .      1,203           *              1,203          0          *
Ieda Santana-Stamm . . . . . . . . . . . . . . . . . . . . . .         45           *                 45          0          *
Jochen Scheel. . . . . . . . . . . . . . . . . . . . . . . . .     11,194           *             11,194          0          *
Nico Scheer. . . . . . . . . . . . . . . . . . . . . . . . . .      1,703           *              1,703          0          *
Lothar Schleithoff . . . . . . . . . . . . . . . . . . . . . .      2,271           *              2,271          0          *
Michael Schoor . . . . . . . . . . . . . . . . . . . . . . . .      3,613           *              3,613          0          *
Stefan Schulte-Merker. . . . . . . . . . . . . . . . . . . . .     21,144           *             21,144          0          *
Daniela Schulz . . . . . . . . . . . . . . . . . . . . . . . .         45           *                 45          0          *
Frieder Schwenk. . . . . . . . . . . . . . . . . . . . . . . .     12,437           *             12,437          0          *
Jost Seibler . . . . . . . . . . . . . . . . . . . . . . . . .      1,906           *              1,906          0          *
Stefan Spieb . . . . . . . . . . . . . . . . . . . . . . . . .      1,135           *              1,135          0          *
Peter Stadler(7) . . . . . . . . . . . . . . . . . . . . . . .    427,917           *            197,917    230,000          *
Miriam Stahl . . . . . . . . . . . . . . . . . . . . . . . . .        210           *                210          0          *
Gordon Stott . . . . . . . . . . . . . . . . . . . . . . . . .      2,007           *              2,007          0          *
Jens Tampe . . . . . . . . . . . . . . . . . . . . . . . . . .      2,271           *              2,271          0          *
Tbg Technologie-Beteiligungs . . . . . . . . . . . . . . . . .    116,230           *            116,230          0          *
Danja Thiel. . . . . . . . . . . . . . . . . . . . . . . . . .         63           *                 63          0          *
Hartmut Tintrup. . . . . . . . . . . . . . . . . . . . . . . .      3,893           *              3,893          0          *
Ute Tinsz. . . . . . . . . . . . . . . . . . . . . . . . . . .        100           *                100          0          *
Torsten Trowe. . . . . . . . . . . . . . . . . . . . . . . . .     12,437           *             12,437          0          *
Gabriele Vacun . . . . . . . . . . . . . . . . . . . . . . . .        416           *                416          0          *
Thomas Wagner. . . . . . . . . . . . . . . . . . . . . . . . .      6,748           *              6,748          0          *
Brigitte Walderich . . . . . . . . . . . . . . . . . . . . . .      5,542           *              5,542          0          *
Andreas Walker . . . . . . . . . . . . . . . . . . . . . . . .         56           *                 56          0          *
Michael Walker . . . . . . . . . . . . . . . . . . . . . . . .        452           *                452          0          *
Catrin Weiler. . . . . . . . . . . . . . . . . . . . . . . . .        870           *                870          0          *
Heike Wessendorf . . . . . . . . . . . . . . . . . . . . . . .        567           *                567          0          *
Branko Zevnik. . . . . . . . . . . . . . . . . . . . . . . . .      3,066           *              3,066          0          *
Sandra Zymny . . . . . . . . . . . . . . . . . . . . . . . . .        113           *                113          0          *
                                                                                       -----------------
 Total  . . . . . . . . . . . . . . . . . . . . . . . . . . .                                 2,270,522
                                                                                       -----------------


_______________________

(1)  Assumes  the  sale  of  all  shares  offered  hereby.
(2)  This  fund is managed by Advent International Corporation ("Advent"), which
     exercises  sole voting and investment power with respect to all shares held
     by  this  fund.  Advent  International Investors II, L.P., which is another
     fund  affiliated  with  Advent, holds 3,614 shares of Exelixis common stock
     but  is  not a selling stockholder. All of the funds affiliated with Advent
     own  3.5%  prior  to  the  offering  and  3.4% after the offering. Jason S.
     Fisherman,  M.D.  is  a vice president of Advent and has been a director of
     Exelixis  since March 1996. Dr. Fisherman disclaims beneficial ownership of
     these  shares  except  for  17,493  shares that are indirectly beneficially
     owned  by  Dr.  Fisherman.
(3)  This  fund is managed by Atlas Venture ("Atlas"), which consists of a group
     of  funds  under common control. All of the funds affiliated with Atlas own
     8.1%  prior  to  the  offering  and  7.6% after the offering. Jean-Francois
     Formela,  M.D.  is  a  general  partner of Atlas and has been a director of
     Exelixis  since  September  1995.  No general partner of Atlas is deemed to
     have  voting  and  investment  power  with  respect to such shares, and Dr.
     Formela  disclaims  beneficial  ownership  of  these  shares.
(4)  Jurgen  Drews,  M.D.  has been a director of Exelixis since July 1998. Dr.
     Drews was Chairman of the Board of Biomedicine L.P. (formerly International
     BM  Biomedicine  Holdings  AG),  from  October  1997  until  January  2001.
(5)  Edmund  Olivier de Vezin is a general partner of Oxford Bioscience Partners
     and  was  a director of Exelixis from July 1997 until May 2001. Mr. Olivier
     disclaims  beneficial ownership of these shares except to the extent of his
     proportionate  partnership  interest  in  these  shares.
(6)  Dr.  Papadopoulos  has  been a director of Exelixis since December 1994 and
     Chairman  of the Board since January 1998. Dr. Papadopoulos' stock holdings
     include  10,000  shares held by Foundation Sante, of which Dr. Papadopoulos
     is  co-trustee,  and  30,000  shares that Dr. Papadopoulos has the right to
     acquire  pursuant  to an option exercisable within 60 days of May 14, 2001,
     17,605  of  which  would  be  subject  to  repurchase  by  Exelixis.
(7)  Dr.  Stadler  has been a director of Exelixis since April 1998. Dr. Stadler
     has  been Managing Director of Artemis Pharmaceuticals GmbH since May 2001.
     Dr. Stadler's stock holdings consist of 167,500 shares that Dr. Stadler has
     the  right  to  acquire pursuant to an option exercisable within 60 days of
     May  14,  2001, 41,042 of which would be subject to repurchase by Exelixis.

          We may from time to time supplement or amend the prospectus to reflect
     the  required  information  concerning  a  transferee,  pledgee,  donee  or
     successor  to  the  Selling  Stockholders  named  in  the  prospectus.