UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                                  SCHEDULE 13G


                    Under the Securities Exchange Act of 1934

                                (Amendment No. )*


                         Avant Immunotherapeutics, Inc.
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)

                                    053491106
                                 (CUSIP Number)


                                December 31, 2001
             (Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                   [x]      Rule 13d-1(b)
                                   [ ]      Rule 13d-1(c)
                                   [ ]      Rule 13d-1(d)

         *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

         The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


CUSIP NO. 001084102                13G                         Page 2 of 7 Pages

1  NAME OF REPORTING PERSON
   S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

   Forstmann-Leff Associates, LLC
   52-2169043

2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                (a) [ ]

                                                (b) [ ]

3  SEC USE ONLY


4  CITIZENSHIP OR PLACE OF ORGANIZATION

   Delaware

                    5  SOLE VOTING POWER
   NUMBER OF
     SHARES            None
  BENEFICIALLY
    OWNED BY        6  SHARED VOTING POWER
      EACH
    REPORTING          3,888,500 shares
     PERSON
      WITH
                    7  SOLE DISPOSITIVE POWER

                       None

                    8  SHARED DISPOSITIVE POWER

                       3,888,500 shares

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         3,888,500 shares (includes shares beneficially owned by FLA
         Advisers L.L.C.)

10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
    SHARES
                                                    [ ]
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

    6.8%

12  TYPE OF REPORTING PERSON

    IA, OO


CUSIP NO. 001084102                13G                         Page 3 of 7 Pages

1  NAME OF REPORTING PERSON
   S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

   FLA Advisers L.L.C.
   13-3942422

2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                (a) [ ]

                                                (b) [ ]

3  SEC USE ONLY


4  CITIZENSHIP OR PLACE OF ORGANIZATION

   New York


                    5  SOLE VOTING POWER
   NUMBER OF
     SHARES            None
  BENEFICIALLY
    OWNED BY        6  SHARED VOTING POWER
      EACH
    REPORTING          3,888,500 shares
     PERSON
      WITH
                    7  SOLE DISPOSITIVE POWER

                       None

                    8  SHARED DISPOSITIVE POWER

                       3,888,500 shares

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    3,888,500 shares

10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
    SHARES

                                                   [ ]
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

    6.8%

12  TYPE OF REPORTING PERSON

    IA, OO


                                                               Page 4 of 7 Pages

Item 1(a) NAME OF ISSUER:

         Avant Immunotherapeutics, Inc.

Item 1(b) ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

         119 Fourth Avenue
         Needham, MA 02494

Item 2(a) NAME OF PERSON FILING:

         See Item 1 of the cover pages attached hereto

Item 2(b) Address of Principal Business Office, or if none, residence:

         590 Madison Avenue
         New York, New York 10022

Item 2(c) CITIZENSHIP:

         See Item 4 of the cover pages attached hereto

Item 2(d) TITLE OF CLASS OF SECURITIES:

         Common Stock, par value $.01

Item 2(e) CUSIP NUMBER:

         053491106

Item 3    Forstmann-Leff   Associates,   LLC,  a  Delaware   limited   liability
          company,is a registered  investment  adviser  under Section 203 of the
          Investment  Advisers Act of 1940 (the "Act").  FLA Advisers  L.L.C., a
          New York limited liability company, is a registered investment adviser
          under  the  Act.  The  members  of  Forstmann-Leff  Associates,  LLC's
          Investment Committee are also the managers of FLA Advisers L.L.C.


                                                               Page 5 of 7 Pages

Item 4 OWNERSHIP:

          (a)  Amount beneficially owned: See Item 9 of the cover pages attached
               hereto

          (b)  Percent of Class: See Item 11 of the cover pages attached hereto

          (c)  See Items 5 through 8 of the cover pages attached hereto

Item 5 OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

                  Not Applicable

Item 6 OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

                  Various clients of the reporting persons have the right to
                  receive or the power to direct the receipt of dividends from,
                  or the proceeds from the sale of, the Common Stock of Avant
                  Immunotherapeutics, Inc. No one client's interest in the
                  Common Stock of Avant Immunotherapeutics, Inc. is more than
                  five percent of the total outstanding Common Stock.

Item 7  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
        SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:

                  Not Applicable

Item 8 IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:

                  Not Applicable

Item 9 NOTICE OF DISSOLUTION OF GROUP:

                  Not Applicable

Item 10 CERTIFICATION:

                  By signing below I certify that, to the best of my knowledge
                  and belief, the securities referred to above were acquired and
                  are held in the ordinary course of business and were not
                  acquired and are not held for the purpose of or with the
                  effect of changing or influencing the control of the issuer of
                  the securities and were not acquired and are not held in
                  connection with or as a participant in any transaction having
                  that purpose or effect.



                                                               Page 6 of 7 Pages


                                   SIGNATURES

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.


February 14, 2002


                                   FORSTMANN-LEFF ASSOCIATES, LLC



                                   By:      /s/ Joseph Sullivan
                                            Chief Operating Officer



                                   FLA ADVISERS L.L.C.


                                   By:      /s/ Joseph Sullivan
                                            Chief Operating Officer



                                                              Page 7 of 7 Pages


                                                                       Exhibit A

                                    AGREEMENT

                  The undersigned, Forstmann-Leff Associates, LLC and FLA
Advisers L.L.C. agree that the statement to which this exhibit is appended is
filed on behalf of each of them.


February 14, 2002

                                   FORSTMANN-LEFF ASSOCIATES, LLC


                                   By:      /s/ Joseph Sullivan
                                            Chief Operating Officer



                                   FLA ADVISERS L.L.C.


                                   By:      /s/ Joseph Sullivan
                                            Chief Operating Officer