UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
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OMB APPROVAL
OMB Number: 3235-0145
Expires: February 28, 2009
Estimated average burden
hours per response 14.5
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Warren T. Lazarow, Esq.
O’Melveny & Myers LLP
2765 Sand Hill Road
Menlo Park, CA 94025
(650) 473-2600
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Paul S. Scrivano, Esq.
O’Melveny & Myers LLP
Times Square Tower
7 Times Square
New York, NY 10036
(212) 326-2000
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1.
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Names of Reporting Persons
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Palo Alto Investors, Inc.
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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California
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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0
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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0
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 0
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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0%
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14.
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Type of Reporting Person (See Instructions)
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CO, HC
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1.
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Names of Reporting Persons
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Palo Alto Investors, LLC
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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California
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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0
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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0
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 0
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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0%
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14.
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Type of Reporting Person (See Instructions)
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IA, OO
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1.
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Names of Reporting Persons
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William Leland Edwards
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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U.S.A.
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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28,000
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8. Shared Voting Power
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0
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9. Sole Dispositive Power
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28,000
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10. Shared Dispositive Power
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0
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 28,000
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)______
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13.
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Percent of Class Represented by Amount in Row (11)
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0.1%
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14.
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Type of Reporting Person (See Instructions)
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IN, HC
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1.
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Names of Reporting Persons
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Anthony Joonkyoo Yun, MD
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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U.S.A.
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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0
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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0
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 0
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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0%
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14.
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Type of Reporting Person (See Instructions)
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IN, HC
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Filer
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Date
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Transaction
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Purchased or Sold
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Average Price Per Share
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PAI, LLC
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9/03/2010
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Sale
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2,847,294
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$ 2.85
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PAI, LLC
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9/02/2010
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Sale
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44,500
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$ 3.04
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PALO ALTO INVESTORS, INC.
By: /s/ Mark Shamia
Mark Shamia, Chief Operating Officer
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PALO ALTO INVESTORS, LLC
By: /s/ Mark Shamia
Mark Shamia, Chief Operating Officer
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/s/ Anthony Joonkyoo Yun
Anthony Joonkyoo Yun, MD
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/s/ William Leland Edwards
William Leland Edwards
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