UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
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OMB APPROVAL
OMB Number: 3235-0145
Expires: February 28, 2009
Estimated average burden
hours per response 14.5
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Warren T. Lazarow, Esq.
O’Melveny & Myers LLP
2765 Sand Hill Road
Menlo Park, CA 94025
(650) 473-2600
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Paul S. Scrivano, Esq.
O’Melveny & Myers LLP
Times Square Tower
7 Times Square
New York, NY 10036
(212) 326-2000
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1.
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Names of Reporting Persons
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Palo Alto Investors, Inc.
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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|||
(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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California
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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3,564,594
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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3,564,594
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 3,564,594
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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7.1%
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14.
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Type of Reporting Person (See Instructions)
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CO, HC
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1.
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Names of Reporting Persons
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Palo Alto Investors, LLC
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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|||
(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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California
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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3,564,594
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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3,564,594
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 3,564,594
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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7.1%
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14.
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Type of Reporting Person (See Instructions)
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IA, OO
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1.
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Names of Reporting Persons
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William Leland Edwards
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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|||
(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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U.S.A.
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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28,000
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8. Shared Voting Power
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3,564,594
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9. Sole Dispositive Power
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28,000
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10. Shared Dispositive Power
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3,564,594
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 3,592,594
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)______
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13.
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Percent of Class Represented by Amount in Row (11)
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7.1%
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14.
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Type of Reporting Person (See Instructions)
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IN, HC
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1.
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Names of Reporting Persons
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Anthony Joonkyoo Yun, MD
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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|||
(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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U.S.A.
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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3,564,594
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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3,564,594
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 3,564,594
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
|
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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7.1%
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14.
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Type of Reporting Person (See Instructions)
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IN, HC
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1.
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Names of Reporting Persons
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Palo Alto Small Cap Master Fund, L.P.
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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|||
(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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Cayman Islands
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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2,485,022
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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2,485,022
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 2,485,022
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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4.9%
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14.
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Type of Reporting Person (See Instructions)
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PN
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1.
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Names of Reporting Persons
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Palo Alto Small Cap Fund, L.P.
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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Delaware
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power
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0
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8. Shared Voting Power
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2,198,002
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9. Sole Dispositive Power
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0
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10. Shared Dispositive Power
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2,198,002
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 2,198,002
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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|
Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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4.4%
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14.
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Type of Reporting Person (See Instructions)
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PN
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Filer
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Date
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Transaction
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Purchased or Sold
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Average Price Per Share
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PAI, LLC
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7/20/2010
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Sale
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1,300
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$ 3.79
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PAI, LLC
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7/21/2010
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Sale
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400
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$ 3.88
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PAI, LLC
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7/22/2010
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Sale
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3,700
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$ 3.83
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PAI, LLC
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7/23/2010
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Sale
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7,000
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$ 3.98
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PAI, LLC
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7/26/2010
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Sale
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2,900
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$ 4.00
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PAI, LLC
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7/27/2010
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Sale
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3,000
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$ 3.99
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PAI, LLC
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7/28/2010
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Sale
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1,500
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$ 3.90
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PAI, LLC
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7/29/2010
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Sale
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2,300
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$ 3.99
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PAI, LLC
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7/30/2010
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Sale
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1,800
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$ 4.04
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PAI, LLC
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8/2/2010
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Sale
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6,000
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$ 4.05
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PAI, LLC
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8/3/2010
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Sale
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2,600
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$ 4.07
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PAI, LLC
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8/4/2010
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Sale
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1,500
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$ 4.03
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PAI, LLC
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8/5/2010
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Sale
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1,700
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$ 4.02
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PAI, LLC
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8/6/2010
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Sale
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3,600
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$ 3.99
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PAI, LLC
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8/9/2010
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Sale
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1,700
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$ 3.95
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PAI, LLC
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8/10/2010
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Sale
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4,000
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$ 3.76
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PAI, LLC
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8/25/2010
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Sale
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16,900
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$ 3.03
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PAI, LLC
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8/26/2010
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Sale
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16,800
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$ 3.01
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PAI, LLC
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8/27/2010
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Sale
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33,600
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$ 3.02
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PAI, LLC
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8/30/2010
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Sale
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40,900
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$ 2.89
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Small Cap Master
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7/20/2010
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Sale
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3,100
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$ 3.79
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Small Cap Master
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7/21/2010
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Sale
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900
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$ 3.88
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Small Cap Master
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7/22/2010
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Sale
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8,500
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$ 3.83
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Small Cap Master
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7/23/2010
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Sale
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15,900
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$ 3.98
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Small Cap Master
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7/26/2010
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Sale
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6,700
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$ 4.00
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Small Cap Master
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7/27/2010
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Sale
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7,100
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$ 3.99
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Small Cap Master
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7/28/2010
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Sale
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3,600
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$ 3.90
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Small Cap Master
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7/29/2010
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Sale
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5,000
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$ 3.99
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Small Cap Master
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7/30/2010
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Sale
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4,200
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$ 4.05
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Small Cap Master
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8/2/2010
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Sale
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13,800
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$ 4.05
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Small Cap Master
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8/3/2010
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Sale
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6,250
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$ 4.07
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Small Cap Master
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8/4/2010
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Sale
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3,600
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$ 4.03
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Small Cap Master
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8/5/2010
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Sale
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3,800
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$ 4.02
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Small Cap Master
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8/6/2010
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Sale
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8,200
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$ 3.99
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Small Cap Master
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8/9/2010
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Sale
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3,900
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$ 3.95
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Small Cap Master
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8/10/2010
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Sale
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9,400
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$ 3.76
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Small Cap Master
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8/25/2010
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Sale
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38,600
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$ 3.03
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Small Cap Master
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8/26/2010
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Sale
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38,600
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$ 3.01
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Small Cap Master
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8/27/2010
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Sale
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77,200
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$ 3.02
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Small Cap Master
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8/30/2010
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Sale
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94,400
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$ 2.89
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PALO ALTO INVESTORS, INC.
By: /s/ Mark Shamia
Mark Shamia, Chief Operating Officer
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PALO ALTO INVESTORS, LLC
By: /s/ Mark Shamia
Mark Shamia, Chief Operating Officer
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PALO ALTO SMALL CAP MASTER FUND, L.P.
By: Palo Alto Investors, LLC, General Partner
By: Palo Alto Investors, Manager
By: /s/ Mark Shamia
Mark Shamia, Chief Operating Officer
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PALO ALTO SMALL CAP FUND, L.P.
By: Palo Alto Investors, LLC, General Partner
By: Palo Alto Investors, Manager
By: /s/ Mark Shamia
Mark Shamia, Chief Operating Officer
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/s/ Anthony Joonkyoo Yun
Anthony Joonkyoo Yun, MD
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/s/ William Leland Edwards
William Leland Edwards
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