UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934*

                                 Amendment No. 1

                               Quidel Corporation
                               ------------------
                                (Name of Issuer)

                         Common Stock, $0.001 par value
                         ------------------------------
                         (Title of Class of Securities)

                                    74838J101
                                   -----------
                                 (CUSIP Number)

                                 December 31, 2001
                                 -----------------
              (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).






----------------------                              ---------------------------
CUSIP No.  74838J101                  13G                 Page 2 of 9 Pages
----------------------                              ---------------------------

-------- ----------------------------------------------------------------------
    1    NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Oracle Partners, L.P.
-------- ----------------------------------------------------------------------
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a)  [X]
                                                                (b)  [ ]

-------- ----------------------------------------------------------------------
    3    SEC USE ONLY


-------- ----------------------------------------------------------------------
    4    CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware
-------------------------------------------------------------------------------
                 5      SOLE VOTING POWER

 NUMBER OF              0
  SHARES      --------- -------------------------------------------------------
BENEFICIALLY     6      SHARED VOTING POWER
 OWNED BY
   EACH                 1,484,400
 REPORTING    --------- -------------------------------------------------------
PERSON WITH      7      SOLE DISPOSITIVE POWER

                        0
              --------- -------------------------------------------------------
                 8      SHARED DISPOSITIVE POWER

                        1,484,400
-------------------------------------------------------------------------------
    9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,484,400
-------- ----------------------------------------------------------------------
   10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES*

         N/A
-------- ----------------------------------------------------------------------
   11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         5.2%
-------- ----------------------------------------------------------------------
   12    TYPE OF REPORTING PERSON*

         PN
-------- ----------------------------------------------------------------------


                      *SEE INSTRUCTION BEFORE FILLING OUT!






----------------------                              ---------------------------
CUSIP No.  74838J101                  13G                 Page 3 of 9 Pages
----------------------                              ---------------------------

-------- ----------------------------------------------------------------------
    1    NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Oracle Associates, LLC
-------- ----------------------------------------------------------------------
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a)  [X]
                                                                (b)  [ ]

-------- ----------------------------------------------------------------------
    3    SEC USE ONLY


-------- ----------------------------------------------------------------------
    4    CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware
-------------------------------------------------------------------------------
                 5      SOLE VOTING POWER

 NUMBER OF              0
  SHARES      --------- -------------------------------------------------------
BENEFICIALLY     6      SHARED VOTING POWER
 OWNED BY
   EACH                 1,879,200
 REPORTING    --------- -------------------------------------------------------
PERSON WITH      7      SOLE DISPOSITIVE POWER

                        0
              --------- -------------------------------------------------------
                 8      SHARED DISPOSITIVE POWER

                        1,879,200
-------------------------------------------------------------------------------
    9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,879,200
-------- ----------------------------------------------------------------------
   10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

         N/A
-------- ----------------------------------------------------------------------
   11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         6.6%
-------- ----------------------------------------------------------------------
   12    TYPE OF REPORTING PERSON*

         OO
-------- ----------------------------------------------------------------------


                      *SEE INSTRUCTION BEFORE FILLING OUT!






----------------------                              ---------------------------
CUSIP No.  74838J101                  13G                 Page 4 of 9 Pages
----------------------                              ---------------------------

-------- ----------------------------------------------------------------------
    1    NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Larry N. Feinberg
-------- ----------------------------------------------------------------------
    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*      (a)  [X]
                                                                (b)  [ ]

-------- ----------------------------------------------------------------------
    3    SEC USE ONLY


-------- ----------------------------------------------------------------------
    4    CITIZENSHIP OR PLACE OF ORGANIZATION

         United States
-------------------------------------------------------------------------------
                 5      SOLE VOTING POWER

 NUMBER OF              10,000
  SHARES      --------- -------------------------------------------------------
BENEFICIALLY     6      SHARED VOTING POWER
 OWNED BY
   EACH                 2,478,200
 REPORTING    --------- -------------------------------------------------------
PERSON WITH      7      SOLE DISPOSITIVE POWER

                        10,000
              --------- -------------------------------------------------------
                 8      SHARED DISPOSITIVE POWER

                        2,478,200
-------------------------------------------------------------------------------
    9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,488,200
-------- ----------------------------------------------------------------------
   10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

         N/A
-------- ----------------------------------------------------------------------
   11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         8.8%
-------- ----------------------------------------------------------------------
   12    TYPE OF REPORTING PERSON*

         IN
-------- ----------------------------------------------------------------------


                      *SEE INSTRUCTION BEFORE FILLING OUT!




Item 1(a):             Name of Issuer:
---------              --------------

      The name of the issuer is Quidel Corporation (the "Company").

Item 1(b):             Address of Issuer's Principal Executive Offices:
---------              -----------------------------------------------

      The Company's principal executive office is located at 10165 McKellar
Court, San Diego, California 92121.

Item 2(a):  Name of Person Filing:
---------   ---------------------

     This Amendment No. 1 to Schedule 13G ("Amendment No. 1") amends the
Schedule 13G which was filed on April 23, 2001 (the "Schedule 13G") with respect
to the Common Stock (as defined in Item 2(d) below) of the Company and is filed
by:

     (i)    Oracle Partners, L.P., a Delaware limited partnership ("Oracle
            Partners"), with respect to shares of Common Stock directly owned by
            it (1,484,400 shares);

     (ii)   Oracle Associates, LLC, a Delaware limited liability company
            ("Oracle Associates"), which serves as the general partner of Oracle
            Partners and Oracle Institutional Partners, L.P., a Delaware limited
            partnership ("Oracle Institutional" and, together with Oracle
            Partners, the "Partnerships"), with respect to shares of Common
            Stock directly owned by Oracle Partners (1,484,400 shares) and
            Oracle Institutional (394,800 shares); and

     (iii)  Mr. Larry N. Feinberg ("Mr. Feinberg"), who serves as the senior
            managing member of Oracle Associates and is the sole shareholder and
            president of Oracle Investment Management, Inc., a Delaware
            corporation (the "Investment Manager"), with respect to shares of
            Common Stock (a) indirectly owned by Oracle Associates by virtue of
            its control over the Partnerships (1,879,200 shares), (b) indirectly
            owned by the Investment Manager by virtue of the Investment
            Manager's position as investment manager of, and control over shares
            directly owned by, SAM Oracle Investments Inc., a British Virgin
            Islands corporation ("SAM Oracle") (196,100 shares), and Oracle
            Offshore Limited, a Cayman Islands corporation ("Oracle Offshore")
            (402,900 shares) and (c) directly owned by Mr. Feinberg (10,000
            shares).

      The foregoing persons are hereinafter sometimes collectively referred to
as the "Reporting Persons." Any disclosures herein with respect to persons other
than the Reporting Persons are made on information and belief after making
inquiry to the appropriate party.


                                      -5-





Item 2(b):             Address of Principal Business Office or, if None,
---------              --------------------------------------------------
                       Residence:
                       ---------

     The  address  of the  principal  business  office of each of the  Reporting
Persons is 200 Greenwich Avenue, 3rd Floor, Greenwich, CT 06830.

Item 2(c):             Citizenship:
---------              -----------

     Oracle  Partners and Oracle  Associates are organized under the laws of the
State of Delaware. Mr. Feinberg is a citizen of the United States of America.

Item 2(d):             Title of Class of Securities:
----------             ----------------------------

      Common Stock, $0.001 par value ("Common Stock").

Item 2(e):             CUSIP Number:
---------              ------------

     74838J101

Item 3:                If this statement is filed pursuant to Rules 13d-1(b) or
------                 --------------------------------------------------------
                       13d-2(b) or (c), check whether the person filing is a:
                       -----------------------------------------------------

        (a) [ ] Broker or dealer registered under Section 15 of the Act,
        (b) [ ] Bank as defined in Section 3(a)(6) of the Act,
        (c) [ ] Insurance Company as defined in Section 3(a)(19) of the Act,
        (d) [ ] Investment  Company  registered  under  Section  8  of  the
                Investment  Company Act of 1940, (e) ___ [ ] Investment  Adviser
                in accordance with Rule 13d-1 (b)(1)(ii)(E),
        (f) [ ] Employee  Benefit Plan or Endowment Fund in accordance with
                13d-1 (b)(1)(ii)(F),
        (g) [ ] Parent Holding  Company or control person in accordance with
                Rule 13d-1 (b)(1)(ii)(G),
        (h) [ ] Savings  Association  as  defined  in  Section  3(b) of the
                Federal Deposit Insurance Act,
        (i) [ ] Church  Plan  that is  excluded  from the  definition of an
                investment  company  under  Section  3(c)(14) of the Investment
                Company Act of 1940,
        (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).


                                      -6-





Item 4:                Ownership:
------                 ---------

  A.  Oracle Partners, L.P.
      ---------------------
      (a) Amount beneficially owned: 1,484,400
      (b) Percent of class: 5.2% The percentages used herein and in the rest of
this Amendment No. 1 are calculated based upon the 28,410,420 shares of Common
Stock stated to be issued and outstanding as of October 1, 2001, as reflected in
the Company's Quarterly Report on Form 10-Q for the quarter ended September 30,
2001.
      (c) Number of shares as to which such person has:
            (i)    Sole power to vote or direct the vote: -0-
            (ii)   Shared power to vote or direct the vote: 1,484,400
            (iii)  Sole power to dispose or direct the disposition: -0-
            (iv)   Shared power to dispose or direct the disposition:
                   1,484,400

  B.  Oracle Associates, LLC
      ----------------------
      (a) Amount beneficially owned: 1,879,200
      (b) Percent of class: 6.6%
      (c) Number of shares as to which such person has:
            (i)    Sole power to vote or direct the vote: -0-
            (ii)   Shared power to vote or direct the vote: 1,879,200
            (iii)  Sole power to dispose or direct the disposition: -0-
            (iv)   Shared power to dispose or direct the disposition:
                   1,879,200

  C.  Larry N. Feinberg
      -----------------
      (a) Amount beneficially owned: 2,488,200
      (b) Percent of class: 8.8%
      (c) Number of shares as to which such person has:
            (i)    Sole power to vote or direct the vote: 10,000
            (ii)   Shared power to vote or direct the vote: 2,478,200
            (iii)  Sole power to dispose or direct the disposition: 10,000
            (iv)   Shared power to dispose or direct the disposition:
                   2,478,200

Item 5:              Ownership of Five Percent or Less of a Class:
------               --------------------------------------------

      Not applicable.

Item 6:              Ownership of More than Five Percent on Behalf of Another
------               --------------------------------------------------------
                     Person:
                     ------

     Other than as set forth herein, no other person has the right to receive or
the power to direct the receipt of dividends  from,  and proceeds  from the sale
of, the securities reported in this Amendment No. 1.


                                      -7-




Item 7:              Identification and Classification of the Subsidiary
------               ----------------------------------------------------
                     Which Acquired the Security Being Reported on by the
                     -----------------------------------------------------
                     Parent Holding Company:
                     ----------------------

      Not applicable.

Item 8:              Identification and Classification of Members of the Group:
------               ---------------------------------------------------------

      Not applicable.

Item 9:              Notice of Dissolution of Group:
------               ------------------------------

      Not applicable.

Item 10:             Certification:
-------              -------------

      Each of the Reporting Persons hereby makes the following certification:

        By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.

                                  EXHIBIT INDEX

     1. Joint Acquisition Statement pursuant to Rule 13d-1(k) (incorporated by
reference to Exhibit 1 to the Schedule 13G filed by the Reporting Persons with
respect to the Common Stock of the Company on April 23, 2001).


                                      -8-




                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

DATED: February 14, 2002


                                   /s/ Larry N. Feinberg
                                   ---------------------------------------------
                                   Larry N.Feinberg, individually and as senior
                                   managing member of Oracle Associates, LLC, on
                                   behalf of itself and as the general partner
                                   of Oracle Partners, L.P.