FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * POYHONEN JOHN   2. Issuer Name and Ticker or Trading Symbol Ardea Biosciences, Inc./DE [RDEA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 4939 DIRECTORS PLACE 3. Date of Earliest Transaction (Month/Day/Year) 06/19/2012 (Street) SAN DIEGO, CA 92121 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Non-Qualified Stock Option (right to buy)	$ 5.85	06/19/2012		D			12,500	(1)	06/14/2017	Common Stock	12,500	$ 26.15	0	D
Non-Qualified Stock Option (right to buy)	$ 15.69	06/19/2012		D			12,500	(1)	01/01/2018	Common Stock	12,500	$ 16.31	0	D
Non-Qualified Stock Option (right to buy)	$ 15.69	06/19/2012		D			10,000	(1)	01/01/2018	Common Stock	10,000	$ 16.31	0	D
Non-Qualified Stock Option (right to buy)	$ 12.16	06/19/2012		D			12,500	(1)	01/01/2019	Common Stock	12,500	$ 19.84	0	D
Non-Qualified Stock Option (right to buy)	$ 12.16	06/19/2012		D			5,000	(1)	01/01/2019	Common Stock	5,000	$ 19.84	0	D
Non-Qualified Stock Option (right to buy)	$ 12.16	06/19/2012		D			5,000	(1)	01/01/2019	Common Stock	5,000	$ 19.84	0	D
Non-Qualified Stock Option (right to buy)	$ 14.29	06/19/2012		D			12,500	(1)	01/03/2020	Common Stock	12,500	$ 17.71	0	D
Non-Qualified Stock Option (right to buy)	$ 25.97	06/19/2012		D			12,500	(1)	01/02/2021	Common Stock	12,500	$ 6.03	0	D
Non-Qualified Stock Option (right to buy)	$ 16.47	06/19/2012		D			12,500	(1)	01/02/2022	Common Stock	12,500	$ 15.53	0	D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
POYHONEN JOHN 4939 DIRECTORS PLACE SAN DIEGO, CA 92121	X

Signatures

/s/ John W. Poyhonen		06/20/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	This option was canceled pursuant to the Agreement and Plan of Merger, dated as of April 21, 2012, by and among Ardea Biosciences, Inc. ("Ardea"), Zeneca Inc. and QAM Corp. (the "Merger Agreement"), in exchange for a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) the excess of $32.00 (the per share merger consideration pursuant to the Merger Agreement) over the exercise price of the option; and (ii) the number of shares of Ardea common stock underlying the option.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.