Edgar Filing: Epizyme, Inc.

SC 13G/A

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)*

EpiZyme, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

29428V104

(CUSIP Number)

December 31, 2015

(Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)

¨ Rule 13d-1(c)

x Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 29428V104


1.	Name of Reporting Persons MPM BioVentures IV-QP, L.P.
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 1,398,493
		6.	Shared Voting Power 0
		7.	Sole Dispositive Power 1,398,493
		8.	Shared Dispositive Power 0
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,398,493
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 3.4%
12.	Type of Reporting Person (See Instructions) PN

Page 2 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons MPM BioVentures IV GmbH & Co. Beteiligungs KG
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Germany
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 53,877
		6.	Shared Voting Power 0
		7.	Sole Dispositive Power 53,877
		8.	Shared Dispositive Power 0
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 53,877
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 0.1%
12.	Type of Reporting Person (See Instructions) PN

Page 3 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons MPM BioVentures IV Strategic Fund, L.P.
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 237,538
		6.	Shared Voting Power 0
		7.	Sole Dispositive Power 237,538
		8.	Shared Dispositive Power 0
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 237,538
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 0.6%
12.	Type of Reporting Person (See Instructions) PN

Page 4 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons MPM Asset Management Investors BV4 LLC
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 39,766
		6.	Shared Voting Power 0
		7.	Sole Dispositive Power 39,766
		8.	Shared Dispositive Power 0
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 39,766
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 0.1%
12.	Type of Reporting Person (See Instructions) OO

Page 5 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons MPM BioVentures IV GP LLC
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,689,908*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,689,908*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,609,908*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.1%
12.	Type of Reporting Person (See Instructions) PN

*	The shares are held as follows: 1,398,493 by MPM BioVentures IV-QP, L.P. (“BV IV QP”), 53,877 by MPM BioVentures IV GmbH & Co. Beteiligungs KG (“BV KG”) and 237,538 by MPM BioVentures IV Strategic Fund, L.P. (“BV SF”). The Reporting Person is the direct general partner of BV IV QP, BV KG and BV SF.

Page 6 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons MPM BioVentures IV LLC
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,729,674*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,729,674*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,729,674*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.2%
12.	Type of Reporting Person (See Instructions) OO

*	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by MPM Asset Management Investors BV4 LLC (“AM BV4”). The Reporting Person is the indirect general partner of BV IV QP, BV KG and BV SF and the manager of AM BV4.

Page 7 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons Luke Evnin
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization United States
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,729,674*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,729,674*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,729,674*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.2%
12.	Type of Reporting Person (See Instructions) IN

The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. MPM BioVentures IV GP LLC (“MPM IV GP”) and MPM BioVentures IV LLC (“MPM IV LLC”) are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

Page 8 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons Ansbert Gadicke
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization United States
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,729,674*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,729,674*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,729,674*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.2%
12.	Type of Reporting Person (See Instructions) IN

*	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

Page 9 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons Vaughn M. Kailian
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization United States
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,729,674*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,729,674*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,729,674*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.2%
12.	Type of Reporting Person (See Instructions) IN

*	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

Page 10 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons James Paul Scopa
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization United States
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,729,674*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,729,674*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,729,674*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.2%
12.	Type of Reporting Person (See Instructions) IN

*	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

Page 11 of 18

CUSIP No. 29428V104


1.	Name of Reporting Persons Todd Foley
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization United States
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 1,729,674*
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 1,729,674*
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,729,674*
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
11.	Percent of Class Represented by Amount in Row (9) 4.2%
12.	Type of Reporting Person (See Instructions) IN

*	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

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Item 1.

(a)

Name of Issuer

EpiZyme, Inc.

(b)

Address of Issuer’s Principal Executive Offices

400 Technology Square

Cambridge, Massachusetts 02139

Item 2.

(a)

Name of Person Filing

MPM BioVentures IV-QP, L.P.

MPM BioVentures IV GmbH & Co. Beteiligungs KG

MPM Asset Management Investors BV4 LLC

MPM BioVentures IV GP LLC

MPM BioVentures IV LLC

MPM BioVentures IV Strategic Fund, L.P.

Luke Evnin

Ansbert Gadicke

Vaughn M. Kailian

James Paul Scopa

Todd Foley

(b)

Address of Principal Business Office or, if none, Residence

c/o MPM Capital LLC

450 Kendall Street

Cambridge, MA 02142

(c)

Citizenship

All entities were organized in Delaware except MPM BioVentures IV GmbH & Co. Beteiligungs KG, which was organized in Germany. The individuals are all United States citizens.

(d)

Title of Class of Securities

Common Stock

(e)

CUSIP Number

29428V104

Item 3.

If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:

Not applicable

Page 13 of 18

Item 4.

Ownership

(a)

Amount Beneficially Owned:


MPM BioVentures IV-QP, L.P.	1,398,493
MPM BioVentures IV GmbH & Co. Beteiligungs KG	53,877
MPM BioVentures IV Strategic Fund, L.P.	237,538
MPM Asset Management Investors BV4 LLC	39,766
MPM BioVentures IV GP LLC	1,689,908	(1)
MPM BioVentures IV LLC	1,729,674	(2)
Ansbert Gadicke	1,729,674	(3)
Luke B. Evnin	1,729,674	(3)
Vaughn M. Kailian	1,729,674	(3)
James Paul Scopa	1,729,674	(3)
Todd Foley	1,729,674	(3)

Percent of Class:


MPM BioVentures IV-QP, L.P.	3.4	%
MPM BioVentures IV GmbH & Co. Beteiligungs KG	0.1	%
MPM BioVentures IV Strategic Fund, L.P.	0.6	%
MPM Asset Management Investors BV4 LLC	0.1	%
MPM BioVentures IV GP LLC	4.1	%
MPM BioVentures IV LLC	4.2	%
Ansbert Gadicke	4.2	%
Luke B. Evnin	4.2	%
Vaughn M. Kailian	4.2	%
James Paul Scopa	4.2	%
Todd Foley	4.2	%

(b)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote


MPM BioVentures IV-QP, L.P.			1,398,493
MPM BioVentures IV GmbH & Co. Beteiligungs KG			53,877
MPM BioVentures IV Strategic Fund, L.P.			237,538
MPM Asset Management Investors BV4 LLC			39,766
MPM BioVentures IV GP LLC			0
MPM BioVentures IV LLC			0
Ansbert Gadicke			0
Luke B. Evnin			0
Vaughn M. Kailian			0
James Paul Scopa			0
Todd Foley			0

Page 14 of 18

(ii)

Shared power to vote or to direct the vote


MPM BioVentures IV-QP, L.P.	0
MPM BioVentures IV GmbH & Co. Beteiligungs KG	0
MPM BioVentures IV Strategic Fund, L.P.	0
MPM Asset Management Investors BV4 LLC	0
MPM BioVentures IV GP LLC	1,689,908	(1)
MPM BioVentures IV LLC	1,729,674	(2)
Ansbert Gadicke	1,729,674	(3)
Luke B. Evnin	1,729,674	(3)
Vaughn M. Kailian	1,729,674	(3)
James Paul Scopa	1,729,674	(3)
Todd Foley	1,729,674	(3)

(iii)

Sole power to dispose or to direct the disposition of


MPM BioVentures IV-QP, L.P.			1,398,493
MPM BioVentures IV GmbH & Co. Beteiligungs KG			53,877
MPM BioVentures IV Strategic Fund, L.P.			237,538
MPM Asset Management Investors BV4 LLC			39,766
MPM BioVentures IV GP LLC			0
MPM BioVentures IV LLC			0
Ansbert Gadicke			0
Luke Evnin			0
Vaughn M. Kailian			0
James Paul Scopa			0
Todd Foley			0

(iv)

Shared power to dispose or to direct the disposition of


MPM BioVentures IV-QP, L.P.	0
MPM BioVentures IV GmbH & Co. Beteiligungs KG	0
MPM BioVentures IV Strategic Fund, L.P.	0
MPM Asset Management Investors BV4 LLC	0
MPM BioVentures IV GP LLC	1,689,908	(1)
MPM BioVentures IV LLC	1,729,674	(2)
Ansbert Gadicke	1,729,674	(3)
Luke B. Evnin	1,729,674	(3)
Vaughn M. Kailian	1,729,674	(3)
James Paul Scopa	1,729,674	(3)
Todd Foley	1,729,674	(3)

(1)	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG and 237,538 by BV SF. The Reporting Person is the direct general partner of BV IV QP, BV KG and BV SF.

(2)	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. The Reporting Person is the indirect general partner of BV IV QP, BV KG and BV SF and the manager of AM BV4.

(3)	The shares are held as follows: 1,398,493 by BV IV QP, 53,877 by BV KG, 237,538 by BV SF and 39,766 by AM BV4. MPM IV GP and MPM IV LLC are the direct and indirect general partners of BV IV QP, BV KG and BV SF and MPM IV LLC is the manager of AM BV4. The Reporting Person is a member of MPM IV LLC.

Page 15 of 18

Item 5.

Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following x.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person

Not Applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not Applicable

Item 8.

Identification and Classification of Members of the Group

Not Applicable

Item 9.

Notice of Dissolution of a Group

Not Applicable

Item 10.

Certification

Not Applicable

Page 16 of 18

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 9, 2016


MPM BIOVENTURES IV-QP, L.P.		MPM BIOVENTURES IV GMBH & CO. BETEILIGUNGS KG

By:	MPM BioVentures IV GP LLC,
	its General Partner	By:	MPM BioVentures IV GP LLC,
			in its capacity as the Managing Limited Partner

By:	MPM BioVentures IV LLC,
	its Managing Member	By:	MPM BioVentures IV LLC,
			its Managing Member

By:	/s/ Luke Evnin
	Name: Luke Evnin	By:	/s/ Luke Evnin
	Title: Member		Name: Luke Evnin
			Title: Member

MPM ASSET MANAGEMENT INVESTORS BV4 LLC		MPM BIOVENTURES IV STRATEGIC FUND, L.P.

By:	MPM BioVentures IV LLC	By:	MPM BioVentures IV GP LLC,
	its Manager		its General Partner

By:	/s/ Luke Evnin	By:	MPM BioVentures IV LLC,
	Name: Luke Evnin		its Managing Member
	Title: Member
		By:	/s/ Luke Evnin
			Name: Luke Evnin
			Title: Member

MPM BIOVENTURES IV GP LLC		MPM BIOVENTURES IV LLC

By:	MPM BioVentures IV LLC,	By:	/s/ Luke Evnin
	its Managing Member	Name: Luke Evnin
		Title:	Member

By:	/s/ Luke Evnin
Name:	Luke Evnin
Title:	Member

By:	/s/ Luke Evnin	By:	/s/ Ansbert Gadicke
	Name: Luke Evnin		Name: Ansbert Gadicke

By:	/s/ Vaughn M. Kailian	By:	/s/ James Paul Scopa
	Name: Vaughn M. Kailian		Name: James Paul Scopa

By:	/s/ Todd Foley
	Name: Todd Foley

EXHIBITS

A:	Joint Filing Agreement

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