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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                                    FORM 8-K

                         PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934


        Date of Report (Date of earliest event reported): August 3, 2005

                         Commission file number 0-15006


                         AVANT Immunotherapeutics, Inc.
             (Exact name of registrant as specified in its charter)
                              --------------------


        Delaware                                               13-3191702
(State or other jurisdiction of                             (I.R.S. Employer
incorporation or organization)                              Identification No.)


                                119 Fourth Avenue
                          Needham, Massachusetts 02494
          (Address of principal executive offices, including zip code)

                                 (781) 433-0771
              (Registrant's telephone number, including area code)


                   (Former name, if changed since last report)
                              --------------------


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions:

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))


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Item 2.02.    Results of Operations and Financial Condition.

On  August  3,  2005,  AVANT  Immunotherapeutics,  Inc.  issued a press  release
announcing  its financial  results for the second quarter of 2005. The full text
of the press  release is  furnished as Exhibit  99.1 hereto is  incorporated  by
reference herein.

Item 9.01.    Financial Statements and Exhibits.
-------       -----
99.1          Press Release of AVANT  Immunotherapeutics,  Inc. dated August 3,
              2005.




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                                    SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended,
the  registrant  has duly  caused  this  report to be filed on its behalf by the
undersigned hereunto duly authorized.


                                     AVANT Immunotherapeutics, Inc.


Dated: August 3, 2005                By:  /s/ Avery W. Catlin
                                         ---------------------------------------
                                           Avery W. Catlin
                                           Senior Vice President and
                                           Chief Financial Officer





                                  Exhibit Index

99.1     Press Release of AVANT Immunotherapeutics, Inc. dated August 3, 2005.