SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.___________)* Interneuron Pharmaceuticals, Inc. ----------------------------------------------------- (Name of Issuer) Common Stock, $.001 par value ------------------------------------------------------------- (Title of Class of Securities) 460573108 ----------------------------------------------------- (CUSIP Number) December 28, 2000 ---------------------------------------------------- (Date of Event) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [XX] Rule 13d-1(c) [ ] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Page 1 of 6 pages CUSIP No. 460573108 13G Page 2 of 6 Pages -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Dov Perlysky -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES 2,548,481 BENEFICIALLY -------------------------------------------------------------- OWNED BY 6 SHARED VOTING POWER EACH 74,000 REPORTING -------------------------------------------------------------- PERSON 7 SOLE DISPOSITIVE POWER WITH 2,548,481 -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 74,000 -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,622,481 -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 6.1% ------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT CUSIP No. 460573108 13G Page 3 of 6 Pages -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Laya Perlysky -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES 2,548,481 BENEFICIALLY -------------------------------------------------------------- OWNED BY 6 SHARED VOTING POWER EACH 74,000 REPORTING -------------------------------------------------------------- PERSON 7 SOLE DISPOSITIVE POWER WITH 2,548,481 -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 74,000 -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,622,481 -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 6.1% ------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT Page 3 of 5 Pages Item 1. (a) Name of Issuer: Interneuron Pharmaceuticals, Inc. (b) Address of Issuer's Principal Executive Offices: One Ledgemont Center 99 Hayden Avenue Lexington, MA 02421 Item 2. (a) Name of Person Filing: This statement is filed on behalf of Dov Perlysky ("Dov") and Laya Perlysky ("Laya") (together, the "Reporting Parties"). See attached Exhibit A which is a copy of their agreement in writing to file this statement on behalf of each of them. (b) Address of Principal Business Office: The Reporting parties address is 9 Beechwood Drive, Lawrence, NY 11559 (c) Citizenship: Both are citizens of the United States. (d) Title of Class of Securities: Common Stock, $.001 par value ("shares") (e) CUSIP Number: 460573108 Item 3. If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b), check whether the person filing is a: (a) [ ] Broker or Dealer registered under Section 15 of the Act (b) [ ] Bank as defined in section 3(a)(6) of the Act (c) [ ] Insurance Company as defined in section 3(a)(19) of the Act (d) [ ] Investment Company registered under section 8 of the Investment Company Act of 1940 (e) [ ] An investment adviser in accordance with 240.13d-1 (b)(1)(ii)(E) (f) [ ] An employee benefit Plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F) (g) [ ] A parent holding Company or control person in accordance with 240.13d-1(b)(1)(ii)(G) (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (i) [ ] A church plan that is excluded from definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940. Page 4 of 5 Pages Item 4. Ownership. (a) (b) The Reporting Parties may each be deemed to beneficially own 2,622,481 shares or 6.1% of the Issuer's shares as follows: (i) 1,890,000 shares owned directly by Dov Perlysky, (ii) 74,000 shares owned by a charitable entity controlled by the Reporting Parties, and (iii) 658,481 shares owned directly by Laya Perlysky (1). (c) Dov has sole voting and dispositive control of shares owned by him. Laya Perlysky has sole voting and dispositve power over shares owned directly by her. Both have the voting and dispositive control over shares owned by the charitable entity. Item 5. Ownership of Five Percent or Less of a Class. Not applicable. Item 6. Ownership of More Than Five Percent on Behalf of Another Person. Not applicable. Item 7. Identification and Classification of the Subsidiary which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group. Not applicable. Item 9. Notice of Dissolution of Group. Not applicable. Item 10. Certification. By signing below, I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. Signature. After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: December 28, 2000 /s/ Dov Perlysky Lawrence, New York ______________________________ Dov Perlysky Dated: December 28, 2000 /s/ Laya Perlysky Lawrence, New York ______________________________ Laya Perlysky ___________________________________________________________________________ (1) Dov and Laya Perlysky are husband and wife. Filing of this statement shall not be deemed an admission by Dov Perlysky or Laya Perlysky that they beneficially own the securities attributed to the other for any purpose. They expressly disclaim beneficial ownership of all securities held by each other.