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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-Q

Commission file number 001-15943

CHARLES RIVER LABORATORIES
INTERNATIONAL, INC.

(Exact Name of Registrant as specified in its Charter)

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        Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ý    No o

        Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (check one):

        Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes o    No ý

        As of August 1, 2008, there were 67,839,491 shares of the registrant's common stock outstanding.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

FORM 10-Q

For the Quarterly Period Ended June 28, 2008

Table of Contents

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Special Note on Factors Affecting Future Results

        This Quarterly Report on Form 10-Q contains forward-looking statements regarding future events and the future results of Charles River Laboratories International, Inc. ("Charles River") that are based on current expectations, estimates, forecasts, and projections about the industries in which Charles River operates and the beliefs and assumptions of our management. Words such as "expect," "anticipate," "target," "goal," "project," "intend," "plan," "believe," "seek," "estimate," "will," "likely," "may," "designed," "would," "future," "can," "could" and other similar expressions that are predictions of or indicate future events and trends or which do not relate to historical matters are intended to identify such forward-looking statements. These statements are based on current expectations and beliefs of Charles River and involve a number of risks, uncertainties, and assumptions that are difficult to predict. For example, we may use forward-looking statements when addressing topics such as: future demand for drug discovery and development products and services, including the outsourcing of these services and other cost reduction activities by our customers; future actions by our management; the outcome of contingencies; changes in our business strategy; changes in our business practices and methods of generating revenue; the development and performance of our services and products; market and industry conditions, including competitive and pricing trends; changes in the composition or level of our revenues; our cost structure; the impact of acquisitions and dispositions; the timing of the opening of new and expanded facilities; our expectations with respect to sales growth, efficiency improvements and operating synergies (including the impact of specific actions intended to cause related improvements); changes in our expectations regarding future stock option, restricted stock, performance awards and other equity grants to employees and directors; changes in our expectations regarding our stock repurchases; assessing (or changing our assessment of) our tax positions for financial statement purposes; and our cash flow and liquidity. You should not rely on forward-looking statements because they are predictions and are subject to risks, uncertainties and assumptions that are difficult to predict. Therefore, actual results may differ materially and adversely from those expressed in any forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this document or in the case of statements incorporated by reference, on the date of the document incorporated by reference. Factors that might cause or contribute to such differences include, but are not limited to, those discussed in our Annual Report on Form 10-K for the year ended December 29, 2007 under the section entitled "Risks Related to Our Business and Industry," the section of this Quarterly Report on Form 10-Q entitled "Management's Discussion and Analysis of Financial Condition and Results of Operations" and in our press releases and other financial filings with the Securities and Exchange Commission. We have no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or risks. New information, future events or risks may cause the forward-looking events we discuss in this report not to occur.

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Part I. Financial Information

Item 1.    Financial Statements

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED)

(dollars in thousands, except per share amounts)

See Notes to Condensed Consolidated Interim Financial Statements

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED)

(dollars in thousands, except per share amounts)

See Notes to Condensed Consolidated Interim Financial Statements

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)

(dollars in thousands, except per share amounts)

See Notes to Condensed Consolidated Interim Financial Statements

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)

(dollars in thousands)

See Notes to Condensed Consolidated Interim Financial Statements

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN
SHAREHOLDERS' EQUITY (UNAUDITED)

(dollars in thousands)

See Notes to Condensed Consolidated Interim Financial Statements

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS

(dollars in thousands, except per share amounts)

1. Basis of Presentation

        The condensed consolidated interim financial statements are unaudited, and certain information and footnote disclosures related thereto normally included in financial statements prepared in accordance with generally accepted accounting principles in the United States of America have been omitted in accordance with Rule 10-01 of Regulation S-X. In the opinion of management, the accompanying unaudited condensed consolidated financial statements were prepared following the same policies and procedures used in the preparation of the audited financial statements and reflect all adjustments (consisting of normal recurring adjustments) considered necessary to state fairly the financial position and results of operations of Charles River Laboratories International, Inc. The results of operations for the interim periods are not necessarily indicative of the results for the entire fiscal year. These condensed consolidated financial statements should be read in conjunction with our Annual Report on Form 10-K for the year ended December 29, 2007.

        Certain amounts in prior-year financial statements and related notes have been reclassified to conform with the current year presentation.

2. Supplemental Balance Sheet Information

        The composition of trade receivables is as follows:

        The composition of inventories is as follows:

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

2. Supplemental Balance Sheet Information (Continued)

        The composition of other current assets is as follows:

        The composition of net property, plant and equipment is as follows:

        Depreciation expense for the six months ended June 28, 2008 and June 30, 2007 was $30,182 and $25,151, respectively.

        The composition of other assets is as follows:

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

2. Supplemental Balance Sheet Information (Continued)

        The composition of other current liabilities is as follows:

        The composition of other long-term liabilities is as follows:

3. Marketable Securities

        The amortized cost, gross unrealized gains, gross unrealized losses and fair value for marketable securities by major security type were as follows:

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

3. Marketable Securities (Continued)

        As of June 28, 2008 and December 29, 2007, we held $19,990 and $38,175 in auction rate securities which are variable rate debt instruments that bear interest rates structured to reset approximately every 7 or 35 days. The auction rate securities owned by us are rated AAA by a major credit rating agency and are guaranteed by the Federal Family Education Loan Program (FFELP). The underlying securities have contractual maturities which are generally greater than ten years. We have classified these investments as long-term consistent with the term of the underlying security. At December 29, 2007, the carrying value of auction rate securities approximated fair value due to the frequent resetting of the interest rates and the market conditions at the time. As of June 28, 2008, the overall credit concerns in the capital markets as well as the failed auctions of these securities have impacted our ability to liquidate these investments. Fair value as of June 28, 2008 was determined by management utilizing an independent valuation which was based upon a discounted cash flow methodology incorporating assumptions that reflect the assumptions a marketplace participant would use. We evaluate securities for other-than-temporary impairment on a quarterly basis and more frequently when conditions warrant such evaluation. We have the ability and intent to hold these securities for a period of time sufficient to recover all gross unrealized losses. Accordingly, we have not recognized an other-than-temporary impairment for these securities.

        Maturities of investments are as follows:

        Marketable securities due after one year are included in other assets on the consolidated balance sheets.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

4. Goodwill and Other Intangible Assets

        The following table displays goodwill and other intangible assets not subject to amortization and other intangible assets that continue to be subject to amortization:

        The changes in the gross carrying amount and accumulated amortization of goodwill are as follows:

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

5. Long-Term Debt

Long-Term Debt

        Long-term debt consists of the following:

        In 2006, we issued $350,000 of 2.25% Convertible Senior Notes (the 2013 notes) due in 2013. The 2013 notes are convertible into approximately 7.2 million shares of our common stock at an initial conversion price of $48.94 per share of common stock. The 2013 Notes are convertible into cash and shares of our common stock (or, at our election, cash in lieu of some or all of such common stock), if any, based on an initial conversion rate, subject to adjustment, of 20.4337 shares of our common stock per $1,000 principal amount of notes (which represents an initial conversion price of $48.94 per share), only in the following circumstances and to the following extent: (1) during any fiscal quarter beginning after July 1, 2006 (and only during such fiscal quarter), if the last reported sale price of our common stock for at least 20 trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding fiscal quarter is more than 130% of the conversion price on the last day of such preceding fiscal quarter; (2) during the five business-day period after any five consecutive trading-day period, or the measurement period, in which the trading price per note for each day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such day; (3) upon the occurrence of specified corporate transactions, as described in the indenture for the 2013 Notes; and (4) at the option of the holder at any time beginning on the date that is two months prior to the stated maturity date and ending on the close of business on the second trading-day immediately preceding the maturity date. Upon conversion, we will pay cash and shares of its common stock (or, at its election, cash in lieu of some or all of such common stock), if any. If we undergo a fundamental change as described in the indenture for the 2013 Notes, holders will have the option to require us to purchase all or any portion of their notes for cash at a price equal to 100% of the principal amount of the notes to be purchased plus any accrued and unpaid interest, including any additional interest to, but excluding, the purchase date.

        As of June 28, 2008, our stock has traded at or above 130% of the conversion price for 20 trading days during the last 30 consecutive trading days of the second quarter. Since the conversion trigger was met, the 2013 notes are convertible at the discretion of the bond holders during the third quarter of 2008. Accordingly, we have classified $175,466 as short term debt on our June 28, 2008 balance sheet.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

5. Long-Term Debt (Continued)

This test is repeated each fiscal quarter. As of June 28, 2008, no conversions have occurred. At June 28, 2008, the fair value of our outstanding 2013 notes was approximately $498,750 based on their quoted market value.

        The interest rates applicable to term loans and revolving loans under the credit agreement are, at our option, equal to either the base rate (which is the higher of the prime rate or the federal funds rate plus 0.50%) or the adjusted LIBOR rate plus an interest rate margin based upon our leverage ratio. Based on our leverage ratio, the margin range for LIBOR-based loans is 0.625% to 0.875%. As of June 28, 2008, the interest rate margin was 0.625%.

        We had $5,466 outstanding under letters of credit as of June 28, 2008.

        Principal maturities of existing debt for the periods set forth in the table below are as follows:

6. Shareholders' Equity

Earnings (Loss) per Share

        Basic earnings per share for the three and six months ended June 28, 2008 and June 30, 2007 were computed by dividing earnings available to common shareholders for these periods by the weighted average number of common shares outstanding in the respective periods. Diluted earnings per share was computed upon the weighted average number of common shares outstanding in the three months ended June 28, 2008 and June 30, 2007 and the six months ended June 28, 2008 and June 30, 2007 and dilutive common stock equivalents outstanding. Potential common shares outstanding principally include stock options under our stock option plans, warrants and the assumed conversion of our 2013 Notes.

        Options to purchase 824,421 and 1,439,767 shares were outstanding in each of the three respective months ended June 28, 2008 and June 30, 2007, but were not included in computing diluted earnings per share because their inclusion would have been anti-dilutive. Options to purchase 941,242 and 2,174,418 shares were outstanding in each of the respective six months ended June 28, 2008 and June 30, 2007, but were not included in computing diluted earnings per share because their inclusion would have been anti-dilutive.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

6. Shareholders' Equity (Continued)

        Basic weighted average shares outstanding for the three and six months ended June 28, 2008 and June 30, 2007 excluded the weighted average impact of 839,151 and 1,066,410 shares, respectively, of non-vested fixed restricted stock awards.

        The following table illustrates the reconciliation of the numerator and denominator of the basic and diluted earnings, (loss) per share computations for income from continuing operations and income (loss) from operations of discontinued businesses:

        The sum of the earnings per share from continuing operations and the loss per share from discontinued operations does not necessarily equal the earnings (loss) per share from net income in the condensed consolidated statements of income for the three and six months ended June 28, 2008 and June 30, 2007 due to rounding.

Treasury Shares

        Our Board of Directors has authorized a share repurchase program, originally authorized on July 27, 2005 and subsequently amended on October 26, 2005, May 9, 2006 and August 1, 2007, to acquire up to a total of $400,000 of common stock. The program does not have a fixed expiration date. In order to facilitate these share repurchases, we entered into Rule 10b5-1 Purchase Plans. As of

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

6. Shareholders' Equity (Continued)

June 28, 2008, approximately $42,513 remains authorized for share repurchases. On July 24, 2008, our Board of Directors increased the existing authorization for repurchase by $200,000.

        Share repurchases during the three and six months ended June 28, 2008 and June 30, 2007 were as follows:

        Additionally, the Company's 2000 Incentive Plan and 2007 Incentive Plan permits the netting of common stock upon vesting of restricted stock awards in order to satisfy individual tax withholding requirements. During the six months ended June 28, 2008 and June 30, 2007, we acquired 80,534 shares for $4,726 and 47,331 shares for $2,227, respectively, as a result of such withholdings. During the three months ended June 28, 2008 and June 30, 2007, we acquired 4,416 shares for $270 and 2,991 shares for $143, respectively.

        The timing and amount of any future repurchases will depend on market conditions and corporate considerations.

Warrants

        Separately and concurrently with the pricing of the 2013 Notes, we issued warrants for approximately 7.2 million shares of our common stock. The warrants give the holders the right to receive, for no additional consideration, cash or shares (at our option) with a value equal to the appreciation in the price of our shares above $59.925, and expire between September 13, 2013 and January 22, 2014 over 90 equal increments. The total proceeds from the issuance of the warrants were $65,423.

        As part of our recapitalization in 1999, we issued 150,000 units, each comprised of a $1,000 senior subordinated note and a warrant to purchase 7.6 shares of our common stock for total proceeds of $150,000. We allocated the $150,000 offering proceeds between the senior subordinated notes ($147,872) and the warrants ($2,128), based upon the estimated fair value. The portion of the proceeds allocated to the warrants is reflected as capital in excess of par in the accompanying consolidated financial statements. Each warrant entitles the holder, subject to certain conditions, to purchase 7.6 shares of our common stock at an exercise price of $5.19 per share of common stock, subject to adjustment under some circumstances. Upon exercise, the holders of warrants would be entitled to purchase 147,250 shares of our common stock as of June 28, 2008. The warrants expire on October 1, 2009.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

7. Income Taxes

        The following table provides a reconciliation of the provision for income taxes on the condensed consolidated statement of income:

        Our overall effective tax rate was 26.4% in the second quarter of 2008 and 28.5% in the second quarter of 2007. The decrease from the 28.5% effective tax rate in the second quarter of 2007 is primarily attributable to tax law changes and reductions in corporate income tax rates in Germany, Canada, and the United Kingdom.

        We adopted FASB Interpretation No. 48, "Accounting for Uncertainty in Income Taxes" ("FIN48"), an interpretation of FASB Statement No. 109 ("SFAS 109") on December 31, 2006. As a result of the implementation of FIN48, we recognized no adjustment in the liability for unrecognized income tax benefits. The total amount of unrecognized tax benefits as of the date of adoption was $17,514. At June 28, 2008 the amount recorded for income tax uncertainties was $24,440. The increase from the date of adoption is primarily due to the continuing evaluation of uncertain tax positions conducted in the current period. The amount of unrecognized tax benefits that, if recognized, would favorably impact the effective tax rate was $8,260 at the date of adoption and $14,457 as of June 28, 2008.

        We continue to recognize interest and penalties related to uncertain tax positions in income tax expense. The total amount of accrued interest relating to uncertain tax positions as of December 31, 2006 and June 28, 2008 was $617 and $2,179, respectively. We have not recorded a provision for penalties associated with uncertain tax positions.

        We conduct business globally and, as a result, we and our subsidiaries file income tax returns in the U.S. and foreign jurisdictions. In the normal course of business, we are subject to examination by taxing authorities throughout the world, including but not limited to such major jurisdictions as Canada, the United Kingdom and the United States. With few exceptions we are no longer subject to U.S. and international income tax examinations for years before 2002.

        We and certain of our subsidiaries are currently under audit by Canada Revenue Agency and the Internal Revenue Service in the United States. In regards to the Internal Revenue Service examinations of the 2004 tax returns of the Company and an acquired subsidiary, we filed our formal protests of certain proposed income tax adjustments with the Appeals Division on July 2, 2007. Based upon discussions with the Internal Revenue Service, we believe it is reasonably possible that we will reach settlement with the Internal Revenue Service on the proposed adjustments within the next twelve months. We do not anticipate that the settlement of the proposed audit adjustments, which relate primarily to issues associated with an acquisition, will have a material impact on our financial position or results of operations. We do not anticipate a change within the next twelve months for the

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

7. Income Taxes (Continued)

remaining unrecognized tax benefits. It is likely that the examination phase of the Canadian audit may conclude in 2008. We believe we have appropriately provided for all uncertain tax positions.

8. Employee Benefits

        The following table provides the components of net periodic benefit cost for our defined benefit plans:

Pension Benefits

Supplemental Retirement Benefits

        We expect to contribute $10,338 to these plans during 2008.

        In April 2008, our Board of Directors voted to freeze the accrual of benefits under our U.S. pension plan effective April 30, 2008. In accordance with SFAS No. 88, "Employers' Accounting for Settlements and Curtailments of Defined Benefit Pension Plans and for Termination Benefits", we recorded a curtailment gain of $3,279 during the quarter ended June 28, 2008. Based on a remeasurement of the U.S. pension plan's assets and liabilities at April 30, 2008, the benefit accrual freeze reduced the projected benefit obligation by $8,298 and resulted in a corresponding adjustment, net of tax, to accumulated other comprehensive income.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

9. Stock-Based Compensation Plans

        We adopted, on a modified prospective basis, the provisions of SFAS No. 123(R), "Share-Based Payment (Revised 2004)," (SFAS No. 123(R)) and related guidance which requires the measurement and recognition of compensation expense for all share-based payment awards made to employees and directors including employee stock options and restricted stock awards based on estimated fair values. Accordingly, stock-based compensation cost is measured at grant date, based on the fair value of the award and is recognized as expense on a straight-line basis over the requisite service period.

        The estimated fair value of our stock-based awards, less expected forfeitures, is amortized over the awards' vesting period on a straight-line basis. The effect of recording stock-based compensation for the three and six months ended June 28, 2008 and June 30, 2007 was as follows:

        We estimate the fair value of stock options using the Black-Scholes valuation model. Key inputs and assumptions used to estimate the fair value of stock options include the exercise price of the award, the expected option term, the risk-free interest rate over the option's expected term, the expected annual dividend yield and the expected stock price volatility. The expected stock price volatility assumption was determined using the historical volatility of our common stock over the expected life of the option. The risk-free interest rate was based on the market yield for the five year U.S. Treasury security. The expected life of options was determined using historical option exercise activity. Management believes that the valuation technique and the approach utilized to develop the underlying assumptions are appropriate in calculating the fair values of our stock options granted. Estimates of fair value are not intended to predict actual future events or the value ultimately realized by persons who receive equity awards.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

9. Stock-Based Compensation Plans (Continued)

        The fair values of stock-based awards granted were estimated on the grant date using the Black-Scholes option-pricing model with the following weighted-average assumptions:

Stock Options

        The following table summarizes the stock option activity in the equity incentive plans from December 30, 2007 through June 28, 2008:

        As of June 28, 2008, the unrecognized compensation cost related to unvested stock options was $23,376 net of estimated forfeitures. This unrecognized compensation will be recognized over an estimated weighted average amortization period of 35 months.

        The total fair value of the options vested during the three and six months ended June 28, 2008 was $1,434 and $9,415, respectively. The total fair value of the options vested during the three and six months ended June 30, 2007 was $875 and $7,943, respectively.

        The total intrinsic value of options exercised during the three and six months ended June 28, 2008 was $4,047 and $10,323, respectively. The total intrinsic value of options exercised during the three and six months ended June 30, 2007 was $13,945 and $17,723, respectively. Intrinsic value is defined as the difference between the market price on the date of exercise and the grant date price.

        The total amount of cash received from the exercise of options during the six months ended June 28, 2008 and June 30, 2007 was $16,512 and $30,585, respectively. The actual tax benefit realized for the tax deductions from option exercises totaled $3,689 and $4,627 for the six months ended June 28, 2008 and June 30, 2007, respectively.

        We settle employee stock option exercises with newly issued common shares.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

9. Stock-Based Compensation Plans (Continued)

Restricted Stock

        Stock compensation expense associated with restricted common stock is charged for the market value on the date of grant, less estimated forfeitures, and is amortized over the awards' vesting period on a straight-line basis.

        The following table summarizes the restricted stock activity from December 29, 2007 through June 28, 2008:

        As of June 28, 2008, the unrecognized compensation cost related to unvested restricted stock was $29,699 net of estimated forfeitures. This unrecognized compensation will be recognized over an estimated weighted average amortization period of 35 months.

        The total fair value of restricted stock grants that vested during the three and six months ended June 28, 2008 was $1,420 and $12,826, respectively. The total fair value of restricted stock grants that vested during the three and six months ended June 30, 2007 was $642 and $7,481, respectively.

Performance-Based Stock Award Program

        During the first quarter of 2007, we adopted a new performance-based stock award program for our executives. Compensation expense associated with awards made under this new program of $856 and $1,538 has been recorded during the three and six months ended June 28, 2008, respectively. Payout of this award is contingent upon achievement of individualized stretch goals during 2008 as determined by our Board of Directors.

10. Commitments and Contingencies

        Various lawsuits, claims and proceedings of a nature considered normal to its business are pending against us. In the opinion of management, the outcome of such proceedings and litigation currently pending will not materially affect our consolidated financial statements. In addition, we have certain purchase commitments related to the completion of ongoing capacity expansion which amounted to approximately $63,000 as of June 28, 2008.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

11. Business Segment Information

        The following table presents sales to unaffiliated customers and other financial information by product line segment:

        A reconciliation of segment operating income to consolidated operating income is as follows:

        A summary of unallocated corporate overhead consists of the following:

        Other general unallocated corporate expenses consist of various departmental costs including corporate accounting, legal and investor relations.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

12. Fair Value

        Effective December 30, 2007, we adopted SFAS No. 157, "Fair Value Measurements" (SFAS 157) and SFAS No. 159 "The Fair Value Option for Financial Assets and Financial Liabilities" (SFAS 159). SFAS 157 defines fair value, establishes a framework for measuring fair value under GAAP and enhances disclosures about fair value measurements. Fair value is defined under SFAS 157 as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. SFAS 157 establishes a fair value hierarchy which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The standard describes three levels of inputs that may be used to measure fair value which are provided in the table below. SFAS 159 allows an entity the irrevocable option to elect fair value for the initial and subsequent measurement for certain financial assets and liabilities on a contract-by-contract basis. The adoption of both SFAS 157 and SFAS 159 had no impact on our financial statements other than the disclosures presented herein.

        Assets measured at fair value on a recurring basis are summarized below:

        The table below presents a reconciliation for all assets measured at fair value on a recurring basis using significant unobservable inputs (Level 3) during the quarter ended June 28, 2008. Our auction rate securities were valued at fair value by management utilizing an independent valuation which used

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

12. Fair Value (Continued)

pricing models and discounted cash flow methodologies incorporating assumptions that reflect the assumptions a marketplace participant would use at June 28, 2008.

        Certain assets and liabilities are measured at fair value on a non-recurring basis. As of June 28, 2008, we have not applied the provisions of SFAS 157 to these assets and liabilities in accordance with FASB "Staff Position FAS 157-2: Effective Date of SFAS 157" (FSP 157-2). FSP 157-2 partially defers the effective date of SFAS 157 for one year for certain nonfinancial assets and nonfinancial liabilities and removes certain leasing transactions from the scope of SFAS 157. SFAS 157 as amended by this FSP is effective for nonfinancial assets and liabilities in fiscal years beginning after November 15, 2008 and will be applied prospectively.

13. Recently Issued Accounting Standards

        In June, the FASB issued FSP No. EITF 03-6-1, Determining Whether Instruments Granted in Share-Based Payment Transactions Are Participating Securities (FSP EITF 03-6-1) which clarifies that share-based payment awards that entitle their holders to receive nonforfeitable dividends before vesting should be considered participating securities. As participating securities, these instruments should be included in the calculation of basic earnings per share. FSP EITF 03-6-1 is effective for financial statements issued for fiscal years beginning after December 15, 2008, as well as interim periods within those years. Once effective, all prior-period earnings per share data presented must be adjusted retrospectively (including interim financial statements, summaries of earnings, and selected financial data) to conform with the provisions of the FSP. Early application is not permitted. We are evaluating the impact of this FSP on our consolidated financial statements.

        In May 2008, the FASB issued FSP No. APB 14-1 Accounting for Convertible Debt Instruments That May Be Settled in Cash upon Conversion (Including Partial Cash Settlement). This FSP specifies that issuers of such instruments should separately account for the liability and equity components in a manner that will reflect the entity's nonconvertible debt borrowing rate when interest cost is recognized in subsequent periods. This FSP is effective for financial statements issued for fiscal years beginning after December 15, 2008 and interim periods within those fiscal years and will be applied

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

13. Recently Issued Accounting Standards (Continued)

retrospectively to all periods presented. We are evaluating the magnitude of the impact of adopting the provisions of this FSP on our consolidated financial statements.

        In March 2008, the FASB issued SFAS No. 161 Disclosures about Derivative Instruments and Hedging Activities (FAS 161). FAS 161 changes the disclosure requirements for derivative instruments and hedging activities. Entities are required to provide enhanced disclosures about (a) how and why an entity uses derivative instruments, (b) how derivative instruments and related hedged items are accounted for under FASB Statement 133 and its related interpretations, and (c) how derivative instruments and related hedged items affect an entity's financial position, financial performance and cash flows. FAS 161 is effective for financial statements issued for fiscal years and interim periods beginning after November 15, 2008, with early application encouraged. This statement is not expected to have an impact on our consolidated financial statements.

        In February 2008, the FASB issued FSP 157-1 and 157-2 that (1) partially deferred the effective date of SFAS 157 for one year for certain nonfinancial assets and nonfinancial liabilities and (2) removed certain leasing transactions from the scope of SFAS 157. SFAS 157 as amended by this FSP is effective for nonfinancial assets and liabilities in fiscal years beginning after November 15, 2008 and will be applied prospectively. The provisions of SFAS 157 are not expected to have a material impact on our consolidated financial statements.

        In February 2008, the FASB issued FSP FAS 140-3: Accounting for Transfers of Financial Assets and Repurchase Financing Transactions (FSP 140-3). FSP 140-3 provides guidance on accounting for a transfer of a financial asset and a repurchase financing. This FSP presumes that an initial transfer for a financial asset and a repurchase financing are considered part of the same arrangement (linked transaction) under Statement 140. However, if certain criteria are met, the initial transfer and repurchase financing shall not be evaluated as a linked transaction and shall be evaluated separately under Statement 140. This FSP is not expected to have an impact on our consolidated financial statements.

        In December 2007, the FASB issued SFAS No. 141(R), Business Combinations (SFAS 141(R)) and No. 160, Noncontrolling Interests in Consolidated Financial Statements (SFAS 160). SFAS 141(R) and SFAS 160 introduce significant changes in the accounting for and reporting of business acquisitions and noncontrolling interests in a subsidiary. SFAS 141(R) continues the movement toward the greater use of fair values in financial reporting and increased transparency through expanded disclosures. SFAS 141(R) changes how business acquisitions are accounted for and will impact financial statements at the acquisition date and in subsequent periods. In addition, SFAS 141(R) will impact the annual goodwill impairment test associated with acquisitions that close both before and after its effective date. SFAS 141(R) applies prospectively to fiscal years, and interim periods within those fiscal years, beginning on or after December 15, 2008. An entity may not apply SFAS 141(R) before that date. We are evaluating the impact of adopting the provisions of SFAS 141(R) and SFAS 160 on our consolidated financial statements.

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (Continued)

(dollars in thousands, except per share amounts)

14. Subsequent Events

        In August 2008, we entered into an agreement to acquire all of the capital stock of privately-held Dusseldorf, Germany based NewLab BioQuality AG (NewLab) for approximately $53,000 in cash. NewLab, a contract service organization, provides safety and quality control services to biopharmaceutical clients and enhances our existing capabilities in process validation services, in consulting services, and in designing International Conference on Harmonisation (ICH)-compliant stability testing programs. The transaction is expected to close in the third quarter of 2008, subject to customary regulatory approvals.

        On July 3, 2008, the Governor of Massachusetts signed into law the Act Relative to Tax Fairness and Business Competitiveness, which substantially reforms the Massachusetts corporate income tax law for years 2009 and beyond. We have analyzed the change in law and estimate that the impact in the third quarter of 2008 will be additional tax expense of approximately $2,800 due to the revaluation of U.S. deferred tax assets. We continue to evaluate the impact of the law change on the effective tax rate for future years.

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Item 2.    Management's Discussion and Analysis of Financial Condition and Results of Operations

        The following discussion should be read in conjunction with our condensed consolidated financial statements and the related notes.

Overview

        We are a leading global provider of solutions that advance the drug discovery and development process, including research models and associated services and outsourced preclinical services. We partner with global pharmaceutical companies, a wide range of biotechnology companies, as well as government agencies, leading hospitals and academic institutions throughout the world in order to bring drugs to market faster and more efficiently. Our broad portfolio of products and services enables our customers to reduce costs, increase speed to market and enhance their productivity and effectiveness in drug discovery and development. We currently operate over 60 facilities in 16 countries worldwide. We have been in business for over 60 years. We have built upon our core competency of laboratory animal medicine and science (research model technologies) to develop a diverse and growing portfolio of regulatory compliant preclinical services which address drug discovery and development in the preclinical arena.

        Our second quarter sales growth was driven by spending by major pharmaceuticals, biotechnology companies and academic institutions on our global products and services, which aid in their development of new drugs and products. Future drivers for our business as a whole are primarily expected to emerge from our customers' continued growing demand for laboratory animal medicine and science and regulatory compliant preclinical services, as well as increased strategic focus on outsourcing. We are engaged in a capacity expansion program to position us to take advantage of these long-term opportunities particularly within Preclinical Services (PCS) business segment. Our capital expenditures of $103.9 million during the six months ended June 28, 2008, and our planned capital expenditures in the range of $220 million to $240 million for 2008, reflect our ongoing commitment to this strategy. During 2008, in addition to opening our new site in Nevada, we have continued constructing additional PCS capacity in Canada, Ohio, Scotland and China. We believe our new China facility will enable us to be the partner of choice for our global pharmaceutical customers as they establish and expand research and development activities China. In the Research Models & Services (RMS) segment, we opened our facility in Maryland, which supports our National Cancer Institute (NCI) contract and commercial production. In addition to internally generated organic growth, our business strategy includes strategic "bolt-on" acquisitions that complement our business, increase the rate of our growth or geographically expand our existing services.

        Total net sales during the second quarter of 2008 were $352.1 million, an increase of 14.5% over the same period last year. The sales increase was due primarily to increased customer demand and higher pricing. The effect of foreign currency translation added 4.1% to sales growth. Our gross margin percentage remained relatively flat compared to the second quarter of 2007, due mainly to improved capacity utilization in the RMS segment partially offset by unfavorable foreign exchange on costs in our PCS Canada locations along with transition costs to our new Nevada facility.

        Our operating income for the second quarter of 2008 was $69.3 million compared to $56.7 million for the second quarter of 2007, an increase of 22.2%. The operating margin was 19.7% for the second quarter of 2008 compared to 18.5% for the prior year, primarily due to lower headquarters costs partially offset by unfavorable foreign exchange on costs in our PCS Canada locations, transition costs to our new Nevada facility and an impairment charge related to the exit of our idle Worcester, Massachusetts facility. Net income from continuing operations was $50.2 million for the second quarter of 2008 compared to $37.8 million for the second quarter of 2007. Diluted earnings per share from continuing operations for the second quarter of 2008 were $0.71 compared to $0.55 for the second quarter of 2007, an increase of 29.1%.

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        Total net sales during the six months ended June 28, 2008 were $689.8 million, an increase of 15.2% over the same period last year. The sales increase was due primarily to increased customer demand and higher pricing, with strong sales in both PCS and RMS. The effect of foreign currency translation added 4.1% to sales growth. Our gross margin decreased to 38.9% of net sales for the six months ended June 28, 2008, compared to 39.5% of net sales for the first six months of 2007, due primarily to unfavorable foreign exchange on costs in our PCS Canada locations along with start-up and transition costs for our PCS Nevada facility partially offset by improved capacity utilization in the RMS segment.

        Our operating income for the six months ended June 28, 2008 was $132.8 million compared to $111.4 million for the six months ended June 30, 2007, an increase of 19.2%. Our operating margin was 19.3% for the six months ended June 28, 2008 compared to 18.6% for the prior year. Net income from continuing operations was $95.3 million for the six months ended June 28, 2008 compared to $75.1 million for the six months ended June 30, 2007. Diluted earnings per share from continuing operations for the first six months of 2008 were $1.35 compared to $1.10 for the first six months of 2007.

        We report two segments: RMS and PCS, which reflect the manner in which our operating units are managed.

        Our RMS segment, which represented 49.1% of net sales in the second quarter of 2008, includes research models, genetically engineered models and services (GEMS), research animal diagnostics, discovery services, consulting and staffing services, vaccine support and in vitro technology (primarily endotoxin testing). Net sales for this segment increased 20.2% for the second quarter of 2008 compared to the second quarter of 2007, due to increased small model sales in Europe, increased consulting and staffing services and strong in vitro sales. Favorable foreign currency translation increased the net sales gain by 7.1%. We experienced increases in the RMS gross margin compared to last year (to 44.2% from 43.9%, respectively), mainly due to increased utilization as a result of the impact of higher sales. Operating margin decreased to 30.2% compared to 31.5% for the second quarter of 2007 due mainly to higher operating expenses in Japan which are not expected to continue at that level partially offset by improved gross margin.

        Sales on a year to date basis for our RMS business segment increased 19.0% compared to the first six months of 2007, due to increased small model sales in Europe, increased consulting and staffing services and strong in vitro sales, partially offset by lower small model growth in Japan. Operating income on a year to date basis was $108.0 million compared to $92.3 million, an increase of $15.7 million, or 17.0%, from the same period last year. Operating income for the first six months as a percent of net sales decreased to 31.6% compared to 32.2% for the same period last year due to higher operating expenses in Japan partially offset by improved gross margin.

        Our PCS segment, which represented 50.9% of net sales in the second quarter of 2008, includes services required to take a drug through the development process including discovery support, toxicology, pathology, biopharmaceutical, bioanalysis, pharmacokinetics and drug metabolism services as well as Phase I clinical trials. Sales for this segment for the second quarter of 2008 increased 9.6% over the second quarter of 2007. Sales were driven by continuing strong demand for general toxicology studies by pharmaceutical and biotechnology customers partially offset by unfavorable mix due mainly to specialty preclinical services, study delays and capacity constraints at certain PCS locations. Favorable foreign currency increased sales growth by 1.4%. The PCS gross margin decreased to 34.3% for the second quarter of 2008 compared to 35.4% for the second quarter of 2007 due mainly to unfavorable foreign exchange on costs in our PCS Canada location along with transition costs to our new Nevada facility partially offset by improvements at our Massachusetts facility. Operating income decreased to 16.1% of net sales for the second quarter of 2008, compared to 16.8% for 2007 due mainly to the lower gross margin and an impairment charge related to the exit of our Worcester facility. We expect to

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see increasing levels of customer demand in certain of our development services businesses, particularly large model, reproductive and inhalation toxicology. We continue to focus on meeting the growing demand for our preclinical services and increased outsourcing trends through our capital expansion program.

        Sales on a year to date basis for our PCS segment increased 11.7% over the same period last year. Operating income for the first six months decreased to 15.0% of net sales, compared to 16.3% for the first six months of 2007, due mainly to decreased gross margin.

        Our unallocated corporate headquarters cost decreased to $11.7 million in the second quarter of 2008, from $16.0 million in the second quarter of 2007 due mainly to the curtailment of the pension and favorable benefits including health care costs.

Three Months Ended June 28, 2008 Compared to Three Months Ended June 30, 2007

         Net Sales.    Net sales for the three months ended June 28, 2008 were $352.1 million, an increase of $44.7 million, or 14.5%, from $307.4 million for the three months ended June 30, 2007.

         Research Models and Services.    For the three months ended June 28, 2008, net sales for our RMS segment increased to $172.8 million from $143.8 million for the three months ended June 30, 2007, an increase of 20.2%. Favorable foreign currency translation increased sales growth by approximately 7.1%. RMS sales increased due to strong in vitro sales, increased sales in Europe and increased consulting and staffing services.

         Preclinical Services.    For the three months ended June 28, 2008, net sales for our PCS segment were $179.3 million, an increase of $15.7 million, or 9.6%, compared to $163.6 million for the three months ended June 30, 2007. The increase was primarily due to the increased customer demand for toxicology and other preclinical services, offset by an unfavorable mix due mainly to less specialty toxicology, study delays and capacity constraints at certain PCS locations. Favorable foreign currency increased sales growth by 1.4%.

         Cost of Products Sold and Services Provided.    Cost of products sold and services provided for the three months ended June 28, 2008 was $214.1 million, an increase of $27.7 million, or 14.8%, from $186.5 million for the three months ended June 30, 2007. Cost of products sold and services provided for the three months ended June 28, 2008 was 60.8% of net sales, compared to 60.7% for the three months ended June 30, 2007.

         Research Models and Services.    Cost of products sold and services provided for RMS for the three months ended June 28, 2008 was $96.4 million, an increase of $15.7 million, or 19.5%, compared to $80.7 million for the three months ended June 30, 2007. Cost of products sold and services provided decreased as a percentage of net sales to 55.8% for the three months ended June 28, 2008, compared to the three months ended June 30, 2007 at 56.1% of net sales. Increased sales during the quarter resulted in greater facility utilization and greater economics of scale.

         Preclinical Services.    Cost of services provided for the PCS segment for the three months ended June 28, 2008 was $117.7 million, an increase of $11.9 million, or 11.3%, compared to $105.8 million for the three months ended June 30, 2007. Cost of services provided as a percentage of net sales was 65.7% for the three months ended June 28, 2008, compared to 64.6% for the three months ended June 30, 2007. The increase in cost of services provided as a percentage of net sales was primarily due to start-up and transition cost for our Nevada facilities, partially offset by favorable results for our other PCS toxicology locations.

         Selling, General and Administrative Expenses.    Selling, general and administrative expenses for the three months ended June 28, 2008 were $61.1 million, an increase of $5.0 million, or 8.9%, from

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$56.1 million for the three months ended June 30, 2007. Selling, general and administrative expenses for the three months ended June 28, 2008 were 17.3% of net sales compared to 18.2% of net sales for the three months ended June 30, 2007. The decrease as a percentage of sales was due primarily to lower selling, general and administrative expenses in unallocated corporate overhead.

         Research Models and Services.    Selling, general and administrative expenses for RMS for the three months ended June 28, 2008 were $23.6 million, an increase of $6.2 million, or 35.3%, compared to $17.5 million for the three months ended June 30, 2007. Selling, general and administrative expenses increased as a percentage of sales to 13.7% for the three months ended June 28, 2008 from 12.1% for the three months ended June 30, 2007 due mainly to increased support costs and higher operating expenses in Japan.

         Preclinical Services.    Selling, general and administrative expenses for the PCS segment for the three months ended June 28, 2008 were $25.7 million, an increase of $3.0 million, or 13.5%, compared to $22.7 million for the three months ended June 30, 2007. Selling, general and administrative expenses for the three months ended June 28, 2008 increased to 14.3% of net sales, compared to 13.8% of net sales for the three months ended June 30, 2007 due mainly to a charge related to the exit from our idle Worcester facility.

         Unallocated Corporate Overhead.    Unallocated corporate overhead, which consists of various costs primarily related to activities centered at our corporate headquarters, such as compensation (including stock-based compensation), information systems, compliance and facilities expenses associated with our corporate, administration and professional services functions was $11.7 million for the three months ended June 28, 2008, compared to $16.0 million for the three months ended June 30, 2007. The decrease in unallocated corporate overhead during the second quarter of 2008 was due primarily to the curtailment of the pension plan and slower growth in health care costs.

         Amortization of Other Intangibles.    Amortization of other intangibles for the three months ended June 28, 2008 was $7.6 million, a decrease of $0.5 million, from $8.1 million for the three months ended June 30, 2007.

         Preclinical Services.    For the three months ended June 28, 2008, amortization of other intangibles for our PCS segment was $7.0 million, compared to $7.8 million for the three months ended June 30, 2007.

         Operating Income.    Operating income for the three months ended June 28, 2008 was $69.3 million, an increase of $12.6 million, or 22.2%, from $56.7 million for the three months ended June 30, 2007. Operating income for the three months ended June 28, 2008 was 19.7% of net sales, compared to 18.5% of net sales for the three months ended June 30, 2007.

         Research Models and Services.    For the three months ended June 28, 2008, operating income for our RMS segment was $52.2 million, an increase of $6.9 million, or 15.3%, from $45.3 million for the three months ended June 30, 2007. Operating income as a percentage of net sales for the three months ended June 28, 2008 was 30.2%, compared to 31.5% for the three months ended June 30, 2007. The decrease in operating income as a percentage of sales was primarily due to increased operating expenses partially offset by increased utilization as a result of higher sales volume.

         Preclinical Services.    For the three months ended June 28, 2008, operating income for our PCS segment was $28.8 million, an increase of $1.4 million, or 5.2%, from $27.4 million for the three months ended June 30, 2007. Operating income as a percentage of net sales decreased to 16.1%, compared to 16.8% of net sales for the three months ended June 30, 2007. The decrease in operating income as a percentage of net sales was primarily due to lower gross margin partially offset by lower amortization costs and favorable operating expenses.

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         Interest Expense.    Interest expense for the three months ended June 28, 2008 was $3.3 million, compared to $4.9 million for the three months ended June 30, 2007 due primarily to the reduced debt and lower rates.

         Interest Income.    Interest income during the second quarter of 2008 was $2.1 million compared to $2.3 million during the second quarter of 2007.

         Income Taxes.    Income tax expense for the three months ended June 28, 2008 was $17.9 million, an increase of $2.8 million compared to $15.1 million for the three months ended June 30, 2007. The increase was primarily due to higher earnings. Our effective tax rate declined to 26.4% in the second quarter of 2008, from 28.5% in the second quarter of 2007 due mainly to tax law changes and reduction in corporate income tax rates in Germany, Canada and the United Kingdom.

         Net Income.    Net income in the second quarter of 2008 was $50.2 million, compared to $38.0 million in the same period last year. Diluted earnings per share from continuing operations in the second quarter of 2008 were $0.71, compared to $0.55 in the same period last year.

Six Months Ended June 28, 2008 Compared to Six Months Ended June 30, 2007

         Net Sales.    Net sales for the six months ended June 28, 2008 were $689.8 million, an increase of $91.2 million, or 15.2%, from $598.6 million for the six months ended June 30, 2007.

         Research Models and Services.    For the six months ended June 28, 2008, net sales for our RMS segment were $341.4 million, an increase of $54.6 million, or 19.0%, from $286.9 million for the six months ended June 30, 2007, due to strong demand for research models from large pharmaceutical customers in Europe, increased demand for transgenic services and higher sales of in vitro products, partially offset by lower small model growth in Japan. Favorable foreign currency translation increased sales growth by approximately 6.7%. RMS sales increased due to pricing and unit volume increases in both models, including large models, and services. The RMS sales growth was driven by increases in basic research and biotechnology spending, which drove greater demand for our products and services.

         Preclinical Services.    For the six months ended June 28, 2008, net sales for our PCS segment were $348.4 million, an increase of $36.6 million, or 11.7%, compared to $311.8 million for the six months ended June 30, 2007. The increase in PCS sales was primarily due to the increased customer demand for toxicology reflecting increased customer outsourcing partially offset by unfavorable mix due mainly to specialty preclinical services. Favorable foreign currency increased sales growth by 1.8%.

         Cost of Products Sold and Services Provided.    Cost of products sold and services provided for the six months ended June 28, 2008 was $421.5 million, an increase of $59.4 million, or 16.4%, from $362.1 million for the six months ended June 30, 2007. Cost of products sold and services provided for the six months ended June 28, 2008 was 61.1% of net sales, compared to 60.5% for the six months ended June 30, 2007.

         Research Models and Services.    Cost of products sold and services provided for RMS for the six months ended June 28, 2008 was $188.8 million, an increase of $28.7 million, or 17.9%, compared to $160.1 million for the six months ended June 30, 2007. Cost of products sold and services provided as a percentage of net sales for the six months ended June 28, 2008 was 55.3% compared to the six months ended June 30, 2007 at 55.8% of net sales. The greater facility utilization was the result of the increased sales during the quarter.

         Preclinical Services.    Cost of services provided for the PCS segment for the six months ended June 28, 2008 was $232.7 million, an increase of $30.7 million, or 15.2%, compared to $202.0 million for the six months ended June 30, 2007. Cost of services provided as a percentage of net sales was 66.8% for the six months ended June 28, 2008, compared to 64.8% for the six months ended June 30,

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2007. The increase in cost of services provided as a percentage of net sales was primarily due to the start-up and transition costs of PCS Nevada facilities.

         Selling, General and Administrative Expenses.    Selling, general and administrative expenses for the six months ended June 28, 2008 were $120.4 million, an increase of $11.3 million, or 10.3%, from $109.1 million for the six months ended June 30, 2007. Selling, general and administrative expenses for the six months ended June 28, 2008 were 17.4% of net sales compared to 18.2% of net sales for the six months ended June 30, 2007. The decrease as a percentage of sales was due primarily to decreases in unallocated corporate overhead.

         Research Models and Services.    Selling, general and administrative expenses for RMS for the six months ended June 28, 2008 were $43.5 million, an increase of $9.8 million, or 29.1%, compared to $33.7 million for the six months ended June 30, 2007. Selling, general and administrative expenses increased as a percentage of sales to 12.8% for the six months ended June 28, 2008 from 11.8% for the six months ended June 30, 2007 due mainly to higher operating expenses in Japan.

         Preclinical Services.    Selling, general and administrative expenses for the PCS segment for the six months ended June 28, 2008 were $49.5 million, an increase of $5.9 million, or 13.5%, compared to $43.6 million for the six months ended June 30, 2007. Selling, general and administrative expenses for the six months ended June 28, 2008 increased to 14.2% of net sales compared 14.0% for the six months ended June 30, 2007 due mainly to a charge related to the exit of our idle Worcester facility.

         Unallocated Corporate Overhead.    Unallocated corporate overhead, which consists of various costs primarily related to activities centered at our corporate headquarters, such as compensation (including stock-based compensation), information systems, compliance and facilities expenses associated with our corporate, administration and professional services functions was $27.3 million for the six months ended June 28, 2008, compared to $31.7 million for the six months ended June 30, 2007. The decrease in unallocated corporate overhead during the first half of 2007 was due primarily to the curtailment of the pension plan and slower growth in health care costs.

         Amortization of Other Intangibles.    Amortization of other intangibles for the six months ended June 28, 2008 was $15.2 million, a decrease of $0.8 million, from $16.0 million for the six months ended June 30, 2007.

         Preclinical Services.    For the six months ended June 28, 2008, amortization of other intangibles for our PCS segment was $14.0 million, a decrease of $1.2 million from $15.2 million for the six months ended June 30, 2007.

         Operating Income.    Operating income for the six months ended June 28, 2008 was $132.8 million, an increase of $21.4 million, or 19.2%, from $111.4 million for the six months ended June 30, 2007. Operating income for the six months ended June 28, 2008 was 19.3% of net sales, compared to 18.6% of net sales for the six months ended June 30, 2007.

         Research Models and Services.    For the six months ended June 28, 2008, operating income for our RMS segment was $108.0 million, an increase of $15.7 million, or 17.0%, from $92.3 million for the six months ended June 30, 2007. Operating income as a percentage of net sales for the six months ended June 28, 2008 was 31.6%, compared to 32.2% for the six months ended June 30, 2007. The decrease in operating income as a percentage of sales was primarily due to increased operating expenses partially offset by utilization due to the higher sales volume.

         Preclinical Services.    For the six months ended June 28, 2008 operating income for our PCS segment was $52.1 million, an increase of $1.2 million, or 2.5%, from $50.9 million for the six months ended June 30, 2007. Operating income as a percentage of net sales decreased to 15.0%, compared to 16.3% of net sales for the six months ended June 30, 2007. The decrease in operating income as a

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percentage of net sales was primarily due to the start-up and transition costs for our PCS Nevada facilities partially offset by higher sales which resulted in improved operating efficiency and lower amortization costs.

         Interest Expense.    Interest expense for the six months ended June 28, 2008 was $6.7 million, compared to $9.2 million for the six months ended June 30, 2007 due primarily to the lower debt.

         Interest Income.    Interest income for the six months ended June 28, 2008 was $4.8 million compared to $4.6 million for the six months ended June 30, 2007.

         Income Taxes.    Income tax expense for the six months ended June 28, 2008 was $34.8 million, an increase of $4.4 million compared to $30.4 million for the six months ended June 30, 2007. Our effective tax rate was 26.8% for the six months ended June 28, 2008 compared to 28.7% for the six months ended June 30, 2007.

         Net Income (Loss).    Net income for the six months ended June 28, 2008 was $95.3 million compared to a net loss for the six months ended June 30, 2007 of $74.7 million.

Liquidity and Capital Resources

        The following discussion analyzes liquidity and capital resources by operating, investing and financing activities as presented in our condensed consolidated statements of cash flows.

        Our principal sources of liquidity have been our cash flow from operations, our marketable securities and our revolving line of credit arrangements.

        We had marketable securities of $19.9 million and $63.4 million as of June 28, 2008 and December 29, 2007, respectively. As of June 28, 2008 and December 29, 2007, we had $19.9 million and $38.2 million invested in auction rate securities rated AAA by a major credit rating agency. Our auction rate securities are guaranteed by U.S. federal agencies. These auction rate securities provide liquidity via an auction process that resets the applicable interest rate at predetermined calendar intervals, usually every 7 or 35 days. The current overall credit concerns in the capital markets as well as the failed auctions of these securities have impacted our ability to liquidate these investments. If the auctions for the securities we own continue to fail, the investment may not be readily convertible to cash until a future auction of these investments is successful. Based on our ability to access our cash and other short-term investments, our expected operating cash flows, and other sources of cash, we do not anticipate the current lack of liquidity on these investments will affect our ability to operate our business as usual.

        In 2006, we issued $350,000 of 2.25% Convertible Senior Notes (the 2013 notes) due in 2013. The 2013 notes are convertible into approximately 7.2 million shares of our common stock at an initial conversion price of $48.94 per share of common stock. The 2013 Notes are convertible into cash and shares of our common stock (or, at our election, cash in lieu of some or all of such common stock), if any, based on an initial conversion rate, subject to adjustment, of 20.4337 shares of our common stock per $1,000 principal amount of notes (which represents an initial conversion price of $48.94 per share), only in the following circumstances and to the following extent: (1) during any fiscal quarter beginning after July 1, 2006 (and only during such fiscal quarter), if the last reported sale price of our common stock for at least 20 trading days in the period of 30 consecutive trading days ending on the last trading day of the immediately preceding fiscal quarter is more than 130% of the conversion price on the last day of such preceding fiscal quarter; (2) during the five business-day period after any five consecutive trading-day period, or the measurement period, in which the trading price per note for each day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such day; (3) upon the occurrence of specified corporate transactions, as described in the indenture for the 2013 Notes; and (4) at the option of the holder at

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any time beginning on the date that is two months prior to the stated maturity date and ending on the close of business on the second trading-day immediately preceding the maturity date. Upon conversion, we will pay cash and shares of our common stock (or, at our election, cash in lieu of some or all of such common stock), if any. As of December 29, 2007, no conversion triggers were met. If we undergo a fundamental change as described in the indenture for the 2013 Notes, holders will have the option to require us to purchase all or any portion of their notes for cash at a price equal to 100% of the principal amount of the notes to be purchased plus any accrued and unpaid interest, including any additional interest to, but excluding, the purchase date. As of June 28, 2008, our stock traded at 130% of the conversion price for 20 trading days during the last 30 consecutive trading days of the second quarter. Since the conversion trigger was met, the 2013 notes are convertible at the discretion of the bond holders during the third quarter of 2008. Accordingly, we have classified $175.5 million as short term debt on our June 28, 2008 balance sheet. This test is repeated each fiscal quarter. If the conversion test is not met in a subsequent quarter, the notes may be reclassified as long term debt as of the end of such quarter. To date, no conversions have occurred. At June 28, 2008, the fair value of our outstanding 2013 notes was approximately $498,750 based on their quoted market value.

        In the event a bond holder exercises the conversion right prior to April 15, 2013, the amount of the settlement would be based upon the 30 consecutive trading day period of our common stock starting on the second trading day following the bondholder delivery of a conversion notice. We would make a cash payment equal to the principal amount of the bonds being converted and pay either cash or stock or a combination (our choice) in a value equal for the amount of conversion value in excess of such principal amount. Additionally, under the bond hedge we would receive payment comparable to the amount of conversion value in excess of such principal amount.

        Cash and cash equivalents totaled $262.4 million at June 28, 2008, compared to $225.4 million at December 29, 2007.

        Net cash provided by operating activities for the six months ending June 28, 2008 and June 30, 2007 was $125.2 million and $93.4 million, respectively. The increase in cash provided by operations was primarily due to net income and increased depreciation. Our days sales outstanding decreased to 38 days as of June 28, 2008 compared to 40 days as of June 30, 2007 but increased from 35 days as of December 29, 2007. Our days sales outstanding includes deferred revenue as an offset to accounts receivable in the calculation.

        Net cash used in investing activities for the six months ending June 28, 2008 and June 30, 2007 was $69.0 million and $93.1 million, respectively. Our capital expenditures in 2008 were $103.9 million of which $33.7 million was related to RMS and $70.2 million to PCS. For 2008, we project capital expenditures to be in the range of $220—$240 million. We anticipate that future capital expenditures will be funded by operating activities and existing credit facilities.

        Net cash used in financing activities for the six months ending June 28, 2008 and June 30, 2007 was $26.8 million and $15.1 million, respectively. During 2008, we purchased $57.9 million of treasury stock partially offset by proceeds from exercises of employee stock options of $16.7 million and proceeds from debt of $20.0 million. During 2007, we purchased $9.0 million of treasury stock and repaid debt of $38.0 million offset by exercises of employee stock options of $30.6 million.

New Accounting Pronouncements

        In June, the FASB issued FSP No. EITF 03-6-1, Determining Whether Instruments Granted in Share-Based Payment Transactions Are Participating Securities (FSP EITF 03-6-1) which clarifies that share-based payment awards that entitle their holders to receive nonforfeitable dividends before vesting should be considered participating securities. As participating securities, these instruments should be included in the calculation of basic earnings per share. FSP EITF 03-6-1 is effective for financial statements issued for fiscal years beginning after December 15, 2008, as well as interim periods within

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those years. Once effective, all prior-period earnings per share data presented must be adjusted retrospectively (including interim financial statements, summaries of earnings, and selected financial data) to conform with the provisions of the FSP. Early application is not permitted. We are evaluating the impact of this FSP on our consolidated financial statements.

        In May 2008, the FASB issued FSP No. APB 14-1 Accounting for Convertible Debt Instruments That May Be Settled in Cash upon Conversion (Including Partial Cash Settlement). This FSP specifies that issuers of such instruments should separately account for the liability and equity components in a manner that will reflect the entity's nonconvertible debt borrowing rate when interest cost is recognized in subsequent periods. This FSP is effective for financial statements issued for fiscal years beginning after December 15, 2008 and interim periods within those fiscal years and will be applied retrospectively to all periods presented. We are evaluating the magnitude of the impact of adopting the provisions of this FSP on our consolidated financial statements.

        In March 2008, the FASB issued SFAS No. 161 Disclosures about Derivative Instruments and Hedging Activities (FAS 161). FAS 161 changes the disclosure requirements for derivative instruments and hedging activities. Entities are required to provide enhanced disclosures about (a) how and why an entity uses derivative instruments, (b) how derivative instruments and related hedged items are accounted for under FASB Statement 133 and its related interpretations, and (c) how derivative instruments and related hedged items affect an entity's financial position, financial performance and cash flows. FAS 161 is effective for financial statements issued for fiscal years and interim periods beginning after November 15, 2008, with early application encouraged. This statement is not expected to have an impact on our consolidated financial statements.

        In February 2008, the FASB issued a FSP 157-2 that (1) partially deferred the effective date of SFAS 157 for one year for certain nonfinancial assets and nonfinancial liabilities and (2) removed certain leasing transactions from the scope of SFAS 157. SFAS 157 as amended by this FSP is effective for nonfinancial assets and liabilities in fiscal years beginning after November 15, 2008 and will be applied prospectively. The provisions of SFAS 157 are not expected to have a material impact on our consolidated financial statements.

        In February 2008, the FASB issued FSP FAS 140-3: Accounting for Transfers of Financial Assets and Repurchase Financing Transactions (FSP-140-3). FSP 140-3 provides guidance on accounting for a transfer of a financial asset and a repurchase financing. This FSP presumes that an initial transfer for a financial asset and a repurchase financing are considered part of the same arrangement (linked transaction) under Statement 140. However, if certain criteria are met, the initial transfer and repurchase financing shall not be evaluated as a linked transaction and shall be evaluated separately under Statement 140. This FSP is not expected to have an impact on our consolidated financial statements.

        In December 2007, the FASB issued SFAS No. 141(R), Business Combinations (SFAS 141(R)) and No. 160, Noncontrolling Interests in Consolidated Financial Statements (SFAS 160). SFAS 141(R) and SFAS 160 introduce significant changes in the accounting for and reporting of business acquisitions and noncontrolling interests in a subsidiary. SFAS 141(R) continues the movement toward the greater use of fair values in financial reporting and increased transparency through expanded disclosures. SFAS 141(R) changes how business acquisitions are accounted for and will impact financial statements at the acquisition date and in subsequent periods. In addition, SFAS 141(R) will impact the annual goodwill impairment test associated with acquisitions that close both before and after its effective date. SFAS 141(R) applies prospectively to fiscal years, and interim periods within those fiscal years, beginning on or after December 15, 2008. An entity may not apply SFAS 141(R) before that date. We are evaluating the impact of adopting the provisions of SFAS 141(R) and SFAS 160 on our consolidated financial statements.

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Off-Balance Sheet Arrangements

        The conversion features of our 2013 Notes are equity-linked derivatives. As such, we recognize these instruments as off-balance sheet arrangements. The conversion features associated with these notes would be accounted for as derivative instruments, except that they are indexed to our common stock and classified in stockholders' equity. Therefore, these instruments meet the scope of exception of paragraph 11(a) of SFAS No. 133, "Accounting for Derivatives Instruments and Hedging Activities," and are accordingly not accounted for as derivatives for purposes of SFAS No. 133.

Item 3.    Quantitative and Qualitative Disclosure About Market Risk

        Certain of our financial instruments are subject to market risks, including interest rate risk and foreign currency exchange rates. We generally do not use financial instruments for trading or other speculative purposes.

Interest Rate Risk

        We have entered into two credit agreements, the amended and restated $428 million credit agreement and the $50 million credit agreement. Our primary interest rate exposure results from changes in LIBOR or the base rates which are used to determine the applicable interest rates under our term loans in the $428 million credit agreement and in the $50 million agreement and our revolving credit facilities. Our potential loss over one year that would result from a hypothetical, instantaneous and unfavorable change of 100 basis points in the interest rate would be approximately $3.6 million on a pre-tax basis. The book value of our debt approximates fair value.

        We issued $350 million of the 2013 Notes in a private placement in the second quarter of 2006. The convertible senior debenture notes bear an interest rate of 2.25%. The fair market value of the outstanding notes was $498.8 million on June 28, 2008.

Foreign Currency Exchange Rate Risk

        We operate on a global basis and have exposure to some foreign currency exchange rate fluctuations for our earnings and cash flows. This risk is mitigated by the fact that various foreign operations are principally conducted in their respective local currencies. A portion of our foreign operations' revenue is denominated in U.S. dollars, with the costs accounted for in their local currencies. We attempt to minimize this exposure by using certain financial instruments, for purposes other than trading, in accordance with our overall risk management and our hedge policy. In accordance with our hedge policy, we designate such transactions as hedges as set forth in SFAS No. 133.

        During 2008, we utilized foreign exchange contracts, principally to hedge the impact of currency fluctuations on customer transactions and certain balance sheet items. There were no contracts open as of June 28, 2008.

Item 4.    Controls and Procedures

(a)    Evaluation of Disclosure Controls and Procedures

        Based on their evaluation, required by paragraph (b) of Rules 13a-15 or 15d-15, promulgated by the Securities Exchange Act of 1934 , the Company's principal executive officer and principal financial officer have concluded that the Company's disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) of the Exchange Act are effective as of June 28, 2008 to ensure that information required to be disclosed by the Company in reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in Securities and Exchange Commission rules and forms. Disclosure controls and procedures include,

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without limitation, controls and procedures designed to ensure that information required to be disclosed by an issuer in the reports that it files or submits under the Act is accumulated and communicated to the issuer's management, including its principal executive and principal financial officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, our management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurances of achieving the desired control objectives, and management necessarily was required to apply its judgment in designing and evaluating the controls and procedures. We continually are in the process of further reviewing and documenting our disclosure controls and procedures, and our internal control over financial reporting, and accordingly may from time to time make changes aimed at enhancing their effectiveness and to ensure that our systems evolve with our business.

(b)    Changes in Internal Controls

        There were no changes in the Company's internal controls over financial reporting identified in connection with the evaluation required by paragraph (d) of the Exchange Act Rules 13a-15 or 15d-15 that occurred during the quarter ended June 28, 2008 that materially affected, or were reasonably likely to materially affect, the Company's internal control over financial reporting.

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Part II.    Other Information

Item 1A.    Risk Factors

        In addition to the other information set forth in this report, you should carefully consider the factors discussed in Part I, "Item 1A. Risk Factors" in our Annual Report on Form 10-K for the year ended December 29, 2007, which could materially affect our business, financial condition or future results. The risks described in our Annual Report on Form 10-K are not the only risks facing our Company. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition and/or operating results.

Item 2.    Unregistered Sales of Equity Securities and Use of Proceeds

        The following table provides information relating to the Company's purchases of shares of its common stock during the quarter ended June 28, 2008.

        The Board of Directors of the Company has authorized a share repurchase program, originally authorized on July 27, 2005 and subsequently amended on October 26, 2005, May 9, 2006, August 1, 2007 and July 24, 2008, to acquire up to a total of $600.0 million of common stock. The program does not have a fixed expiration date.

        During the quarter ended June 28, 2008, the Company repurchased 535,000 shares of common stock for approximately $32.7 million. The timing and amount of any future repurchases will depend on market conditions and corporate considerations. Additionally, the Company's Incentive Plans permit the netting of common stock upon vesting of restricted stock awards in order to satisfy individual tax withholding requirements. Accordingly, during the quarter ended June 28, 2008, the Company acquired 4,416 shares as a result of such withholdings for approximately $0.3 million.

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Item 4.    Submission of Matters to a Vote of Security Holders

        At the Company's Annual Meeting of Shareholders held on May 8, 2008, the following proposals were adopted by the votes specified below:

(a)

The following directors were elected to serve until the Company's 2009 Annual Meeting of Shareholders and received the number of votes listed opposite each of their names below:

(b)

The ratification of the appointment of PricewaterhouseCoopers LLP as the Company's independent auditors for fiscal 2008. A total of 61,664,909 shares voted in favor of the ratification, 1,932,529 shares voted against the ratification, and 21,073 shares abstained from voting.

        Computershare Trust Company, N.A., our transfer agent, acted as independent proxy tabulator and Inspector of Election at the Annual Meeting of Shareholders.

Item 6.    Exhibits

(a)

Exhibits

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SIGNATURES

        Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

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QuickLinks

Part I. Financial Information
Item 1. Financial Statements

CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED) (dollars in thousands, except per share amounts)
CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED) (dollars in thousands, except per share amounts)
CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) (dollars in thousands, except per share amounts)
CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) (dollars in thousands)
CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS' EQUITY (UNAUDITED) (dollars in thousands)
CHARLES RIVER LABORATORIES INTERNATIONAL, INC. NOTES TO UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS (dollars in thousands, except per share amounts)

Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations

Item 3. Quantitative and Qualitative Disclosure About Market Risk
Item 4. Controls and Procedures

Part II. Other Information
Item 1A. Risk Factors
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds
Item 4. Submission of Matters to a Vote of Security Holders
Item 6. Exhibits

SIGNATURES