UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*


                                Transgenomic, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    89365K206
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                                 (CUSIP Number)

   Mr. Joseph I. Worsham, II                        with a copy to:
   General Counsel                                  John D. Hogoboom, Esq.
   WS Capital Management, L.P.                      Lowenstein Sandler PC
   300 Crescent Court, Ste. 1111                    65 Livingston Avenue
   Dallas, Texas  75201                             Roseland, New Jersey 07068
   (214) 756-6073                                   (973) 597-2500
-------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                October 23, 2006
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)



If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g),  check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule,  including all exhibits. See Section 240.13d-7 for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





Cusip No.   89365K206
--------------------------------------------------------------------------------
1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
   (entities only):
                       BC Advisors, LLC
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)   [ ]
         (b)   [X]
--------------------------------------------------------------------------------
3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  AF
--------------------------------------------------------------------------------
5.  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):
                      Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:   Texas

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:           5,214,106*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                 0
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:      5,214,106*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:           0
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:   5,214,106*

--------------------------------------------------------------------------------
12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares
    (See Instructions):          Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   10.6%*

--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):   HC/CO

--------------------------------------------------------------------------------

          * Based on 49,189,672 shares of common stock issued and outstanding as
of September  26, 2006, as reported by the issuer in its  Prospectus  filed with
the Securities and Exchange Commission on September 28, 2006.






Cusip No.   89365K206
--------------------------------------------------------------------------------
1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
   (entities only):
                       SRB Management, L.P.
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)   [ ]
         (b)   [X]
--------------------------------------------------------------------------------
3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  AF
--------------------------------------------------------------------------------
5.  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):
                      Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:   Texas

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:           5,214,106*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                 0
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:      5,214,106*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:           0
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:  5,214,106*

--------------------------------------------------------------------------------
12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares
    (See Instructions):          Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   10.6%*

--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):   IA/PN

--------------------------------------------------------------------------------

* Based on  49,189,672  shares of common  stock  issued  and  outstanding  as of
September 26, 2006, as reported by the issuer in its  Prospectus  filed with the
Securities and Exchange Commission on September 28, 2006.





Cusip No.   89365K206
--------------------------------------------------------------------------------
1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons
   (entities only):
                       Steven R. Becker
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)   [ ]
         (b)   [X]
--------------------------------------------------------------------------------
3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  AF
--------------------------------------------------------------------------------
5.  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):
                      Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:   United States

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:             5,214,106*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                 0
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:        5,214,106*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:           0
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:    5,214,106*

--------------------------------------------------------------------------------
12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares
    (See Instructions):          Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   10.6%*

--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):  HC/IN

--------------------------------------------------------------------------------

* Based on  49,189,672  shares of common  stock  issued  and  outstanding  as of
September 26, 2006, as reported by the issuer in its  Prospectus  filed with the
Securities and Exchange Commission on September 28, 2006.





Item 5.   Interest in Securities of the Issuer
          ------------------------------------

          (a)  Steven R.  Becker is the  beneficial  owner of  5,214,106  Shares
beneficially  owned by BCA and SRB Management  for the accounts of SRBGC,  SRBQP
and SRB Offshore.  BCA and SRB Management are the beneficial owners of 5,214,106
Shares for the accounts of SRBGC, SRBQP and SRB Offshore.

          (b) Each of the  Reporting  Persons  has sole power to vote and direct
the disposition of the Shares for which it is deemed to be the beneficial owner.

          (c) The only transaction in Shares that was  effected since the filing
of the Schedule 13D was the purchase of 1,320,000 shares at a price of $0.41 per
Share on October 23, 2006, which purchase was effected in an ordinary  brokerage
transaction.

          (d) Not applicable.

          (e) Not applicable.


Item 7.   Material to be Filed as Exhibits.
          --------------------------------

          1. Joint Filing Agreement, dated October 23, 2006, entered into by and
among BC Advisors, LLC, SRB Management, L.P. and Steven R. Becker.






                                    SIGNATURE


          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


October 23, 2006

                                      BC ADVISORS, LLC

                                      By: /s/ Steven R. Becker
                                         ---------------------------------------
                                          Steven R. Becker, Member


                                      SRB MANAGEMENT, L.P.

                                      By:  BC Advisors, LLC, its general partner

                                      By: /s/ Steven R. Becker
                                         ---------------------------------------
                                      Steven R. Becker, Member


                                          /s/ Steven R. Becker
                                         ---------------------------------------
                                          Steven R. Becker


      Attention: Intentional misstatements or omissions of fact constitute
                Federal criminal violations (See 18 U.S.C. 1001)




                                                                      EXHIBIT 1

                             JOINT FILING AGREEMENT


In accordance with Rule 13d-1(k),  as promulgated under the Securities  Exchange
Act of 1934,  as amended,  the persons  named below agree to the joint filing on
behalf  of  each of them a  Statement  on  Schedule  13D  (including  amendments
thereto) with regard to the common stock of Transgenomic, Inc. and further agree
that this  Joint  Filing  Agreement  be  included  as an  Exhibit  to such joint
filings.  In evidence thereof,  the undersigned,  being duly authorized,  hereby
execute this Joint Filing Agreement as of October 23, 2006..


                                      BC ADVISORS, LLC

                                      By: /s/ Steven R. Becker
                                         ---------------------------------------
                                          Steven R. Becker, Member


                                      SRB MANAGEMENT, L.P.

                                      By:  BC Advisors, LLC, its general partner

                                      By: /s/ Steven R. Becker
                                         ---------------------------------------
                                      Steven R. Becker, Member


                                          /s/ Steven R. Becker
                                         ---------------------------------------
                                          Steven R. Becker