UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
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1.
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Names of Reporting Persons
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Palo Alto Investors, Inc.
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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California
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power 0
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8. Shared Voting Power 3,372,077
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9. Sole Dispositive Power 0
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10. Shared Dispositive Power 3,372,077
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person 3,372,077
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)
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13.
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Percent of Class Repr
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16.0%
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14.
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Type of Reporting Person (See Instructions)
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CO, HC
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1.
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Names of Reporting Persons
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Palo Alto Investors, LLC
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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California
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power 0
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8. Shared Voting Power 3,372,077
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9. Sole Dispositive Power 0
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10. Shared Dispositive Power 3,372,077
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person3,372,077
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|
12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
|
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Instructions)
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13.
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Percent of Class Represented by Amount in Row (11)
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16.0%
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14.
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Type of Reporting Person (See Instructions)
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IA, OO
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1.
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Names of Reporting Persons
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William Leland Edwards
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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U.S.A.
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power 4,700
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8. Shared Voting Power 3,372,077
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9. Sole Dispositive Power 4,700
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10. Shared Dispositive Power 3,372,077
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person3,376,777
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12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
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Instructions)______
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13.
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Percent of Class Represented by Amount in Row (11)
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16.0%
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14.
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Type of Reporting Person (See Instructions)
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IN, HC
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1.
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Names of Reporting Persons
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Anthony Joonkyoo Yun, MD
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2.
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a)
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(b)
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X
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3.
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SEC Use Only
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4.
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Source of Funds (See Instructions)
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AF
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5.
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Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____
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6.
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Citizenship or Place of Organization
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U.S.A.
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Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
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7. Sole Voting Power 0
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8. Shared Voting Power 3,372,077
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9. Sole Dispositive Power 0
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10. Shared Dispositive Power 3,372,077
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11.
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Aggregate Amount Beneficially Owned by Each Reporting Person3,372,077
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|
12.
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Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
|
|
Instructions)
|
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13.
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Percent of Class Represented by Amount in Row (11)
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16.0%
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14.
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Type of Reporting Person (See Instructions)
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IN, HC
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Purchaser
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Source of Funds
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Amount
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PAI LLC
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Funds Under Management
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$90,225,990
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Person Effecting the Transaction
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Date
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Purchase or Sale
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Quantity
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Price per Share
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PAI, LLC
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1/3/2011
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purchase
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11,600
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$ 18.12
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PAI, LLC
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1/4/2011
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purchase
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18,100
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$ 17.87
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PAI, LLC
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1/5/2011
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purchase
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19,500
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$ 17.88
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PAI, LLC
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1/7/2011
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purchase
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75,400
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$ 17.91
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PAI, LLC
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1/10/2011
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purchase
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42,000
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$ 17.02
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PAI, LLC
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1/13/2011
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purchase
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13,800
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$ 17.85
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PAI, LLC
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1/14/2011
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purchase
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15,500
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$ 18.07
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PAI, LLC
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1/24/2011
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purchase
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12,700
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$ 17.62
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PAI, LLC
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1/25/2011
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purchase
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16,600
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$ 17.39
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PALO ALTO INVESTORS, INC.
By: /s/ Mark Shamia_____________________
Mark Shamia, Chief Operating Officer
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PALO ALTO INVESTORS, LLC
By: /s/ Mark Shamia____________________
Mark Shamia, Chief Operating Officer
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/s/ Anthony Joonkyoo Yun____________
Anthony Joonkyoo Yun, MD
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/s/ William Leland Edwards____________
William Leland Edwards
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